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Pharmacological and Therapeutic Applications of Esculetin

International Journal of Molecular Sciences, 2022
Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in various plants such as Sonchus grandifolius, Aesculus turbinata, etc. Free radicals lead to the development of oxidative stress causing inflammation, arthritis, cancer, diabetes, fatty liver disease, etc.
, Jeena Gupta, Chuanju Liu
exaly   +3 more sources

Examining the Antioxidant and Superoxide Radical Scavenging Activity of Anise, (Pimpinella anisum L. Seeds), Esculetin, and 4-Methyl-Esculetin Using X-ray Diffraction, Hydrodynamic Voltammetry and DFT Methods [PDF]

Pharmaceuticals, 2023
Pimpinella anisum L., or anise, is a plant that, besides its nutritional value, has been used in traditional medical practices and described in many cultures in the Mediterranean region. A possible reason for anise’s therapeutic value is that it contains
Miriam Rossi, Francesco Caruso, Natalie Thieke, Stuart Belli, Alana Kim, Elisabetta Damiani, Camilla Morresi, Tiziana Bacchetti   +7 more
doaj   +2 more sources

Cytotoxicity of Esculetin Compared with Vinblastine and Paclitaxel in PC-3 Prostate Cancer Cells [PDF]

Current Oncology
Background/Objectives: Metastatic prostate cancer is among the therapy-resistant human neoplasms. PC-3 is a commonly used experimental cell line that does not express androgen receptors.
Ana I. García-Pérez, Virginia Rubio, Angel Herráez, Lilian Puebla, José C. Diez   +4 more
doaj   +2 more sources

Cooperation between a root fungal endophyte and host-derived coumarin scopoletin mediates Arabidopsis iron nutrition. [PDF]

New Phytol
Summary Iron acquisition is a critical challenge for plants, especially in iron‐deficient soils. Recent research underscores the importance of root‐exuded coumarins in modulating the root microbiome community structure and facilitating iron uptake. However, interactions between root‐associated fungi and coumarins in plant iron nutrition remain unknown.
Van Dijck L, Esposto D, Huelsmann C, Malisic M, Piro A, Giehl RFH, Balcke GU, Tissier A, Parker JE.   +8 more
europepmc   +2 more sources

Umbelliferone and esculetin protect against N-nitrosodiethylamine-induced hepatotoxicity in rats [PDF]

Cell Biology International, 2016
N-nitrosodiethylamine (NDEA), a nitrosamine compound, is known to cause liver damage through the generation of reactive oxygen species (ROS), resulting in oxidative damage to macromolecules such as DNA, and the consequent development of cancer.
Ellis, Elizabeth M., Subramaniam, Sudhakar Raja   +1 more
core   +4 more sources

Comparative Hepatoprotective Effects of Esculetin and Its Derivatives Against Oxidative Stress [PDF]

Antioxidants
In this study, we evaluated the antioxidant activities of esculetin and four synthesized derivatives (E1, 2-oxo-2H-1-benzopyran-6,7-diyl diacetate; E2, 7-hydroxy-2-oxo-2H-1-benzopyran-6-yl acetate; E3, 7-(methoxymethoxy)-2-oxo-2H-1-benzopyran-6-yl ...
Yoonjeong Kim, Jihyun Kwon, Jae-Hwan Kwak, In-hwan Baek, Younghwa Kim   +4 more
doaj   +2 more sources

Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review

Molecules, 2017
Esculetin, synonymous with 6,7-dihydroxycoumarin, is the main active ingredient of the traditional Chinese medicine Cortex Fraxini. The twig skin or trunk bark of Cortex Fraxini are used by herb doctors as a mild, bitter liver and gallbladder meridians ...
Chengyuan Liang
exaly   +3 more sources

Esculetin attenuates cerebral ischemia-reperfusion injury and protects neurons through Nrf2 activation in rats [PDF]

Brazilian Journal of Medical and Biological Research
Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a key transcription factor in the antioxidant response and is associated with various chronic diseases.
Zhe Zhang, Jiayun Zhang, Rui Shi, Tiantian Xu, Shiduo Wang, Junbiao Tian   +5 more
doaj   +2 more sources

Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4+Foxp3+ Regulatory T Cells

Frontiers in Immunology, 2018
Psoriasis is an autoimmune and inflammatory skin disease affecting around 2–3% of the world's population. Patients with psoriasis need extensive treatments with global immunosuppressive agents that may cause severe side effects.
Zhenhua Dai
exaly   +3 more sources

Esculetin inhibits ferroptosis after ICH by promoting NUDT1-mediated m7G methylation modification of GPX4 [PDF]

Scientific Reports
Intracerebral hemorrhage (ICH) is the most morbid of all stroke types with a high mortality and significant disability burden. Inhibiting ferroptosis after ICH will effectively treat ICH and improve prognosis.
Jinbing Gong, Zhanwei Zhang, Libo Li, Zhigang Mei, Tao Chen   +4 more
doaj   +2 more sources