Esculetin Inhibits Cancer Cell Glycolysis by Binding Tumor PGK2, GPD2, and GPI
Frontiers in Pharmacology, 2020 Glycolysis can improve the tolerance of tissue cells to hypoxia, and its intermediates provide raw materials for the synthesis and metabolism of the tumor cells.
Song-Tao Wu
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Esculetin inhibits the PI3K/Akt/mTOR pathway and enhances anti-colorectal cancer activity via binding to ENO1 [PDF]
Frontiers in PharmacologyIntroductionColorectal cancer (CRC) ranks as the third most prevalent malignant tumor worldwide and is the second leading cause of cancer-related mortality.
Jianing Ma +10 more
doaj +2 more sources
In silico evaluation of the anti Helicobacter pylori activity of selected bioactive compounds from Aloe vera [PDF]
Scientific ReportsHelicobacter pylori causes peptic ulcer, which is estimated to affect about half of the human population. Current treatments present with adverse side effects, and increasing antibiotic resistance have intensified the search for alternative therapeutic ...
Uwem Okon Edet +9 more
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Protective Effects and Mechanisms of Esculetin against H2O2-Induced Oxidative Stress, Apoptosis, and Pyroptosis in Human Hepatoma HepG2 Cells [PDF]
MoleculesOxidative stress plays a crucial role in the pathogenesis of many diseases. Esculetin is a natural coumarin compound with good antioxidant and anti-inflammatory properties.
Ying Luo +5 more
doaj +2 more sources
NMDA receptor modulation by Esculetin: Investigating behavioral, biochemical and neurochemical effects in schizophrenic mice model [PDF]
Saudi Pharmaceutical JournalSchizophrenia, a global mental health disorder affecting approximately 1 % of the population, is characterized by neurotransmitter dysregulation, particularly dopamine, serotonin, and glutamate.
Iqra Khalid +4 more
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An NMR Study on Esculetin and It's Derivatives
Chinese Journal of Magnetic Resonance, 2019 The derivatives of esculetin contain hydroquinone groups that have various biological activities. In this study, the esculetin derivatives 2~14 were obtained by inducting the methoxy and hydroxyl groups into the 5, 6, 7 and 8 positions, and pheny group ...
LIU Ji-hong, JIN Kun, WANG Ping, LUO Gen
doaj +2 more sources
COUMARIN (ESCULETIN) - AN ANTIRHEUMATOID ARTHRITIC COMPOUND: AN UPDATE [PDF]
Asian Journal of Pharmaceutical and Clinical Research, 2018 Context: Esculetin is a natural polyphenolic compound. It is chemically 6,7-dihydroxycoumarin and one of the ingredients of Cortex fraxini, a Chinese traditional medicine. It is used as a dietary supplement and found as non-toxic.
S, Jaya Kumari
core +4 more sources
Antioxidants, 2020 Oxidative stress (OS) appears to be an important determinant during the different stages of progression of Alzheimer’s Disease (AD). In particular, impaired antioxidant defense mechanisms, such as the decrease of glutathione (GSH) and nuclear factor ...
Letizia Pruccoli +2 more
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Targeting cellular plasticity: esculetin-driven reversion of stem cell-like characteristics and EMT phenotype in transforming cells with sequential p53/p73 knockdowns [PDF]
BMC CancerThe intricate interplay of cancer stem cell plasticity, along with the bidirectional transformation between epithelial-mesenchymal states, introduces further intricacy to offer insights into newer therapeutic approaches.
Ankit Mathur +4 more
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Antioxidant and anti‑inflammatory effects of esculin and esculetin (Review). [PDF]
Exp Ther MedFraxinus chinensis Roxb is a deciduous tree, which is distributed worldwide and has important medicinal value. In Asia, the bark of Fraxinus chinensis Roxb is a commonly used traditional Chinese medicine called Qinpi. Esculetin is a coumarin compound derived from the bark of Fraxinus chinensis Roxb and its glycoside form is called esculin.
Ju S +6 more
europepmc +3 more sources