Results 21 to 30 of about 4,462 (212)

Esculetin Combats Multidrug-Resistant Salmonella Infection and Ameliorates Intestinal Dysfunction via the Nrf2 Pathway [PDF]

Antioxidants
The increasing incidence of multidrug-resistant (MDR) Salmonella enterica serovar Typhimurium (S. Tm), known for causing invasive enteric infections, presents a significant public health challenge.
Wenjiao Xu, Wenjun Ding, Liyan Jia, Kui Zhu, Qingfeng Luo   +4 more
doaj   +2 more sources

Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway [PDF]

Brazilian Journal of Medical and Biological Research, 2015
This study investigated the in vitro and in vivo antiproliferative activity of esculetin against hepatocellular carcinoma, and clarified its potential molecular mechanisms. Cell viability was determined by the MTT (tetrazolium) colorimetric assay.
J. Wang, M.L. Lu, H.L. Dai, S.P. Zhang, H.X. Wang, N. Wei   +5 more
doaj   +3 more sources

Synergy, Additivity and Antagonism between Esculetin and Six Commonly Used Chemotherapeutics in Various Malignant Melanoma Cell Lines—An Isobolographic Analysis

Molecules, 2023
(1) Malignant melanomas are dangerous skin cancers, and the treatment of melanomas with various cytostatic drugs often causes side effects and after their prolonged use resistance to these drugs appears.
Paula Wróblewska-Łuczka, Agnieszka Góralczyk, Jarogniew J. Łuszczki   +2 more
doaj   +1 more source

Antioxidant Efficacy of Esculetin against Tert-Butyl Hydroperoxide-Induced Oxidative Stress in HEK293 Cells

Current Issues in Molecular Biology, 2022
Esculetin is an antioxidant and anti-inflammatory compound derived from coumarin. Oxidative stress can cause overproduction of reactive oxygen species (ROS), which can lead to the development of chronic kidney failure.
Woo Kwon Jung, Su-Bin Park, Hwa Young Yu, Yong Hwan Kim, Junghyun Kim   +4 more
doaj   +1 more source

The Coumarin-Derivative Esculetin Protects against Lipotoxicity in Primary Rat Hepatocytes via Attenuating JNK-Mediated Oxidative Stress and Attenuates Free Fatty Acid-Induced Lipid Accumulation

Antioxidants, 2023
Coumarin derivates have been proposed as a potential treatment for metabolic-dysfunction-associated fatty liver disease (MAFLD). However, the mechanisms underlying their beneficial effects remain unclear.
Mengmeng Xia, Zongmei Wu, Junyu Wang, Manon Buist-Homan, Han Moshage   +4 more
doaj   +1 more source

Esculetin Alleviates Acute Liver Failure following Lipopolysaccharide/D-Galactosamine in Male C57BL/6 Mice [PDF]

Iranian Journal of Medical Sciences, 2021
Background: Acute liver failure (ALF) is a fatal clinical situation that rapidly leads to the loss of normal liver function. Esculetin is a natural herbal compound used for the management of various diseases such as cardiovascular and renal disorders. In
Seyed-Mahdi Mohamadi-Zarch, Tourandokht Baluchnejadmojarad, Davood Nourabadi, Samira Ramazi, Morteza Nazari-Serenjeh, Mehrdad Roghani   +5 more
doaj   +1 more source

Esculetin as bioactive marker: towards a rational scientific approach for the treatment of hyperuricemia using Traditional Chinese Medicine

Brazilian Journal of Pharmaceutical Sciences, 2020
Traditional Chinese Herbal Medicine has been used to prevent and cure disease in China for thousands of years and has gained global interest in recent decades. The Erding formula is a Chinese Pharmacopeia (ChP)-listed herbal preparation used for treating
Jieyu Zuo, Wugang Zhang, Hui Jian, Nádia Bou-Chacra, Raimar Löbenberg   +4 more
doaj   +1 more source

Effect of Esculetin on Tert-Butyl Hydroperoxide-Induced Oxidative Injury in Retinal Pigment Epithelial Cells In Vitro

Molecules, 2022
Esculetin is a coumarin-derived compound with antioxidant and anti-inflammatory properties. The current study aims to evaluate the therapeutic implications of esculetin on retinal dysfunction and uncover the underlying mechanisms.
Woo Kwon Jung, Su-Bin Park, Hwa Young Yu, Yong Hwan Kim, Junghyun Kim   +4 more
doaj   +1 more source

Pharmacological activities of esculin and esculetin: A review

Medicine, 2023
Esculin and esculetin are 2 widely studied coumarin components of Cortex Fraxini, which is a well-known herbal medicine with a 2000-year history. In vivo and in vitro studies have demonstrated that both have a variety of pharmacological activities, including antioxidant, anti-tumor, anti-inflammatory, antibacterial, antidiabetic, immunomodulatory, anti-
Ting Cai, Bin Cai
openaire   +2 more sources

Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells

Molecules, 2022
Inflammation is a major root of several diseases such as allergy, cancer, Alzheimer’s, and several others, and the present state of existing drugs provoked researchers to search for new treatment strategies.
Thanasekaran Jayakumar, Chun-Jen Huang, Ting-Lin Yen, Chih-Wei Hsia, Joen-Rong Sheu, Periyakali Saravana Bhavan, Wei-Chieh Huang, Cheng-Ying Hsieh, Chih-Hsuan Hsia   +8 more
doaj   +1 more source