Results 31 to 40 of about 4,462 (212)
Toxics, 2022 We examined the protective effects of esculetin and fucoidan against the neurotoxicity of ZnO NPs in rats. Ninety rats were divided into nine groups and pre-treated with esculetin or fucoidan 1 h before ZnO NP administration on a daily basis for 2 weeks.
Woo-Ju Song +6 more
doaj +1 more source
COSY catalyses trans-cis isomerization and lactonization in the biosynthesis of coumarins [PDF]
, 2019 Coumarins, also known as 1,2-benzopyrones, comprise a large class of secondary metabolites that are ubiquitously found throughout the plant kingdom.
Boerjan, Wout +15 more
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BMC Cancer, 2023 Background The “Differentiation therapy” has been emerging as a promising and more effective strategy against acute leukemia relapses. Objective In extension to the revolutionising therapeutic outcomes of All Trans Retinoic Acid (ATRA) to induce terminal
Ankit Mathur, Aman Gangwar, Daman Saluja
doaj +1 more source
Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.) [PDF]
, 2013 Chicory (Cichorium intybus) has been shown to induce enzymes of pharmacokinetic relevance (cytochrome P450; CYP). The aim of this study was to investigate the effects of selected secondary plant metabolites with a global extract of chicory root, on the ...
Ekstrand, Bo +2 more
core +1 more source
Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition [PDF]
, 2018 Antibiotic resistance is a growing threat worldwide, causing serious problems in the treatment of microbial infections. The discovery and development of new drugs is urgently needed to overcome this problem which has greatly undermined the clinical ...
Gutiérrez-Barranquero, José A. +3 more
core +2 more sources
Esculetin Ameliorates Carbon Tetrachloride-Mediated Hepatic Apoptosis in Rats [PDF]
International Journal of Molecular Sciences, 2011 Esculetin (ESC) is a coumarin that is present in several plants such as Fraxinus rhynchophylla and Artemisia capillaris. Our previous study found that FR ethanol extract (FREtOH) significantly ameliorated rats’ liver function. This study was intended to investigate the protective mechanism of ESC in hepatic apoptosis in rats induced by carbon ...
Tien, Yun-Chen +6 more
openaire +2 more sources
Veterinary Sciences, 2023 Mammary gland tumors are the most common neoplasms in female dogs, of which 50% are malignant. Esculetin, a coumarin derivative, reportedly induces death in different types of cancer cells.
Jawun Choi +3 more
doaj +1 more source
Inhibitory Effects of Esculetin on Melanin Biosynthesis
Biological and Pharmaceutical Bulletin, 2004 To investigate the structure-activity relationship of coumarins for the inhibitory activity on mushroom tyrosinase, the 50% inhibitory concentration (IC50 values) of 18 coumarins and four cinnamic acid derivatives were measured. Among these compounds, esculetin had the strongest inhibitory activity (IC50=43 microM) on mushroom tyrosinase.
Yukimitsu, Masamoto +5 more
openaire +3 more sources
BMC Pharmacology and Toxicology, 2021 Background Esculetin is a natural coumarin derivative from various plants with multiple pharmacological effects. Hence, the present study was undertaken to explore the cardio protective potential of esculetin against isoproterenol induced myocardial ...
Chitikela P. Pullaiah +4 more
doaj +1 more source
Metabolome analysis of Arabidopsis thaliana roots identifies a key metabolic pathway for iron acquisition [PDF]
, 2014 Fe deficiency compromises both human health and plant productivity. Thus, it is important to understand plant Fe acquisition strategies for the development of crop plants which are more Fe-efficient under Fe-limited conditions, such as alkaline soils ...
Böttcher, Christoph +7 more
core +3 more sources