Results 171 to 180 of about 7,916,692 (304)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Antitumor effects of volatile components of <i>Magnolia salicifolia</i> essential oil against breast cancer cells are mediated via mitochondrial apoptosis. [PDF]

Front Oncol
Nagata T, Satou T, Ishii K, Sasaki A, Satyal P, Watanabe M, Riggs B, Saida Y.   +7 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Quality and Safety of Extracted Humic Substances as Fundamental Factor of Natural Regulation for the Sustainable Development

Agricultural & Rural Studies
Humic substances as natural biogeochemical macromolecules have been formed over tens of millions of years as a result of the processes of natural destruction of biological systems with a high degree of chemical diversity.
Maksym Melnychuk, Oleksii Petrov, Konstantin Torop, Igor Jakimenko, Linjun Xun, Husheng Zhao   +5 more
doaj  

Targeting skin aging: anti-senescent potential and key enzyme modulation of <i>Lavandula</i> essential oils. [PDF]

Front Pharmacol
Alves-Silva JM, Domingues J, Delgado F, Ribeiro T, Cruz T, Salgueiro L, Girão H, Zuzarte M.   +7 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Chemical and Enantioselective Characterization and Preliminary Biological Activities of <i>Aristolochia lingulata</i> Aerial-Part Essential Oil. [PDF]

Plants (Basel)
Vinueza DR, Flores LM, Gilardoni G, Malagón O.   +3 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Sesquiterpene-Rich Essential Oil From Magnolia officinalis Stem Bark: Chemical Composition, Biological Activities, and In Silico Approach. [PDF]

Chem Biodivers
Thanh NTK, Minh PH, Ni HTN, Hai TQ, Hoai LT, Vinh LB, Quan PM, Luyen ND, Son NT.   +8 more
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source