Results 71 to 80 of about 318,042 (343)

Estrogen-dependent dynamic profile of eNOS-DNA associations in prostate cancer [PDF]

, 2013
In previous work we have documented the nuclear translocation of endothelial NOS (eNOS) and its participation in combinatorial complexes with Estrogen Receptor Beta (ERβ) and Hypoxia Inducible Factors (HIFs) that determine localized chromatin remodeling ...
A Grasselli, A Re, A Watahiki, Agnese Re, Alessandro Guffanti, Alfredo Pontecorvi, Antonella Farsetti, Armando Felsani, Arturo Londono-Vallejo, Aurora Aiello, BD Gehm, C Liu, C Zang, Carlo Gaetano, Claudia Colussi, Costanza Emanueli, CS Ross-Innes, D Bonci, D Fukumura, D Lodygin, DM Huffman, E Schreiber, G Garcia-Cardena, I Mattagajasingh, J Lu, J Veldscholte, JA Baur, JS Carroll, JS Horoszewicz, KH Lim, KP Porkka, L Ying, L Zeng, LJ Zhu, Luis Jaime Castro-Vega, M Yamakuchi, M Yamakuchi, Maurizio C. Capogrossi, MC Haigis, MD Kornberg, MD Robinson, ME Ritchie, MS Zaman, MV Iorio, N Hah, N Nadiminty, NR Bertos, OM Grober, P Gandellini, P Giovannelli, Q Wu, RT Prehn, S Anders, S Baranwal, S Kyo, S Misiti, S Nanni, S Nanni, S Nanni, S Volinia, Silvia Bacchetti, Simona Nanni, T Liu, T Vanhaecke, Valentina Benvenuti, W Fischle, Y Zhang   +66 more
core   +3 more sources

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

The outcome of severely injured patients following traumatic brain injury is affected by gender—A retrospective, multicenter, matched-pair analysis utilizing data of the TraumaRegister DGU®

Frontiers in Neuroscience, 2022
IntroductionTraumatic brain injury (TBI) causes a major health-concern globally. Gender-dependent differences in mortality outcome after TBI have been controversially discussed.Materials and methodsWe conducted a retrospective, multicenter, matched-pair ...
Olivia Mair, Frederik Greve, Rolf Lefering, Peter Biberthaler, Marc Hanschen, the TraumaRegister DGU   +5 more
doaj   +1 more source

Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia [PDF]

, 2018
Perinatal asphyxia (PA) remains as one of the most important causes of short-term mortality, psychiatric and neurological disorders in children, without an effective treatment.
Bellini, Maria Jose, Capani, Francisco, Garcia Segura, Luis Miguel, Saraceno, Gustavo Ezequiel   +3 more
core   +2 more sources

The Role of Artificial Intelligence in Advancing Biosensor Technology: Past, Present, and Future Perspectives

Advanced Materials, EarlyView.
This review explores the transformative role of AI in biosensor technology and provides a holistic interdisciplinary perspective that covers a broader scope of AI‐enabled biosensor technologies across various sectors including healthcare, environmental monitoring, food safety, and agriculture. It also highlights the important role of novel materials in
Tuğba Akkaş, Mahshid Reshadsedghi, Mustafa Şen, Volkan Kılıç, Nesrin Horzum   +4 more
wiley   +1 more source

Urinary polycyclic aromatic hydrocarbon metabolites are positively related to serum testosterone levels of males and serum estradiol levels of females among U.S. adults

Frontiers in Endocrinology, 2022
BackgroundIt has been reported for several years that polycyclic aromatic hydrocarbons (PAHs) could disturb human endocrine function. However, there is still a short of consistent conclusion about the relationship between PAH exposure and levels of ...
Qiming Yuan, Kun Jin, Xianghong Zhou, Zhimei Qiu, Jiakun Li, Di Jin, Zilong Zhang, Chichen Zhang, Lu Yang, Yu Zhan, Shi Qiu, Qiang Wei   +11 more
doaj   +1 more source

Estradiol in elderly men [PDF]

The Aging Male, 2002
The role of estrogens in male physiology has become more evident, as a consequence of the discovery of human models of estrogen deficiency such as estrogen resistance or aromatase deficiency. In males, testosterone is the major source of plasma estradiol, the main biologically active estrogen, only 20% of which is secreted by the testes. Plasma estrone,
A. Vermeulen, S. Goemaere, I. Van Pottelberg, Jean Kaufman   +3 more
openaire   +3 more sources

Leveraging Design of Experiments to Unravel the Amplification Mechanism of Single‐Molecule Wide‐Field Biosensors

Advanced Materials Interfaces, EarlyView.
Detecting single molecules on large interfaces is challenging due to minimal perturbations on the sensing surface. Some biological systems achieve this feat using amplification mechanisms, but their molecular foundations remain unclear. To investigate, a Design of Experiments (DoE) approach examines how pH and ionic strength in conditioning solutions ...
Michele Catacchio, Mariapia Caputo, Lucia Sarcina, Cinzia Di Franco, Matteo Piscitelli, Erika Castrignanò, Paolo Bollella, Gaetano Scamarcio, Eleonora Macchia, Luisa Torsi   +9 more
wiley   +1 more source

The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance

, 2019
Misfolded proteins in the endoplasmic reticulum (ER) activate the unfolded protein response (U PR), which enhances protein folding to restore homeostasis.
Borner, G., Schessner, J., Schmidt, R., Schuck, S.   +3 more
core   +1 more source

Structural features of alkylphenolic chemicals associated with estrogenic activity [PDF]

, 1997
The ability of certain man-made chemicals to mimic the effects of natural steroid hormones and their potential to disrupt the delicate balance of the endocrine system in animals are of increasing concern.
Routledge, EJ, Sumpter, JP
core   +1 more source