Results 71 to 80 of about 345,140 (332)

Rapid Microfluidic Drug Sensitivity Testing Within 5 Days Using Minimal Clinical Tumor Samples

Advanced Science, EarlyView.
This study develops the air‐punched fabrication approach for nanoliter‐scale microcavity arrays with ultra‐smooth microcavity surfaces, with which rapid formation and 3D culture of tumor cell spheroids from small numbers of cell samples, as well as high‐throughput drug sensitivity testing can be achieved within 5 days.
Yi‐Xue Chen, Yi Zhang, Yu‐Jie Yan, Meng‐Ting Zhang, Jian‐Bo Chen, Yi‐Rong Jiang, Jie Wu, Hui‐Feng Wang, Jian‐Zhang Pan, Zhi‐Gang Chen, Jian Huang, Qun Fang   +11 more
wiley   +1 more source

Association between polyunsaturated fatty acid intake and estradiol levels among U.S. women

Frontiers in Nutrition
BackgroundPolyunsaturated fatty acids (PUFAs) play a crucial role in maintaining homeostasis in the body. However, research on the relationship between PUFA intake and estradiol levels is limited.
Lange Guo, Yukui Nan, Kangni Liang, Lizhong Yao, Jiuzhi Li   +4 more
doaj   +1 more source

Serum estradiol to testosterone ratio as a novel predictor of severe preeclampsia in the first trimester

The Journal of Clinical Hypertension, 2023
Preeclampsia (PE) is the most common medical complication during pregnancy and the second leading cause of maternal death worldwide. However, a better predictive model of PE remains to be explored.
Yongmei Shen, Jiasong Cao, Liying Yao, Shanshan Li, Xiaomin Zhao, Wen Li, Zhuo Wei, Lei Zhang, Jianxi Wang, Ying Chang   +9 more
doaj   +1 more source

Weak if any effect of estrogen on spatial memory in rats [PDF]

, 2002
In a number of species, males appear to have spatial abilities that are superior to those of females. The favored explanation for this cognitive difference is hormonal: higher testosterone levels in males than in females.
Farkas, Tamás, Kis, Zsolt, Németh, Hajnalka, Toldi, József, Tóth, Tünde, Varga, Hedvig   +5 more
core  

A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic [PDF]

, 1995
Sewage, a complex mixture of organic and inorganic chemicals, is considered to be a major source of environmental pollution. A random screen of 20 organic man-made chemicals present in liquid effluents revealed that half appeared able to interact with ...
Clark LB, Ema M, Ginsberg J, Henderson BE, Hites RA, J P Sumpter, Klinge KM, Kraybill HF, M G Parker, R White, S Jobling, Spelsberg TC, T Reynolds, Tzukerman MT, Verhagen H   +14 more
core   +2 more sources

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Effects of 17β-estradiol and equilin on atherosclerosis development in female Apoe shl mice

Scientific Reports
The effects of conjugated equine estrogens (CEE) and 17β-estradiol-based hormone replacement therapy (HRT) on atherosclerosis development remain controversial.
Akiyo Kakibuchi, Fumitake Ito, Osamu Takaoka, Nanami Tahara, Mari Kawamata, Kazuya Yabumoto, Akihisa Katayama, Yuko Izumi, Eiko Maeda, Taisuke Mori   +9 more
doaj   +1 more source

Long term effects of aromatase inhibitor treatment in patients with aromatase excess syndrome

Frontiers in Endocrinology
IntroductionAromatase excess syndrome (AEXS) is a rare, autosomal dominant disorder, characterized by enhanced aromatization of androgens and estrogen excess.
Eleni Z. Giannopoulou, Eleni Z. Giannopoulou, Stephanie Brandt, Stephanie Brandt, Stephanie Brandt, Stefanie Zorn, Stefanie Zorn, Stefanie Zorn, Christian Denzer, Christian Denzer, Julia von Schnurbein, Julia von Schnurbein, Maki Fukami, Alexander Kaiser, Martin Schmidt, Martin Wabitsch, Martin Wabitsch, Martin Wabitsch   +17 more
doaj   +1 more source

Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study. [PDF]

, 2019
Circulating ceramide levels are abnormally elevated in age-dependent pathologies such as cardiovascular diseases, obesity and Alzheimer's disease.
Armirotti, Andrea, Assogna, Francesca, Basit, Abdul, Bossù, Paola, Piomelli, Daniele, Piras, Fabrizio, Realini, Natalia, Sensi, Stefano L, Spalletta, Gianfranco, Vozella, Valentina   +9 more
core   +1 more source

The rodent uterotrophic assay: Critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay [PDF]

, 1997
The major protocol features of the immature rat uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the ...
Ashby, J, Beresford, NA, Lefevre, PA, Odum, J, Paton, D, Routledge, EJ, Sumpter, JP, Tittensor, S   +7 more
core   +2 more sources