Results 131 to 140 of about 97,723 (266)
British Journal of Clinical Pharmacology, EarlyView.Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf +6 more
wiley +1 more source
Schematic diagram of the distribution of CpGs in estrogen receptor α promoter CpG island.
, 2015 Schematic diagram of the distribution of CpGs in estrogen receptor α promoter CpG island.
Jessica Hung (801760) +6 more
core +1 more source
Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity
British Journal of Clinical Pharmacology, EarlyView.Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa +5 more
wiley +1 more source
Research in Molecular Medicine, 2014 Background: Phytoestrogens, a group of plant-derived polyphenolic compounds have recently come into considerable attention due to the increasing information on their potential adverse effects in human health.
Ehsan Zayerzadeh +2 more
doaj
, 2019 Discovery of novel estrogen-related receptor α inverse agonists by virtual screening and biological ...
Hui Zhao (7395) +4 more
core +1 more source
BMEMat, EarlyView.Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao +4 more
wiley +1 more source
Estrogen receptor-alpha (ER-α) suppresses expression of its variant ER-α36
, 2009 Recently, we identified and cloned a membrane-based estrogen receptor (ER), ER-α36, which is transcribed from a previously unidentified promoter in the first intron of the original ER-α gene.
Megan Coleman +7 more
core +1 more source
BMEMat, EarlyView.This study develops a nano‐enzyme patch (ezPatch) targeting bone interfaces. Utilizing ligand‐to‐metal charge transfer (LMCT) catalysis and bone‐targeting ligands on copper nanosheets, ezPatch simultaneously scavenges reactive oxygen species (ROS) and generates oxygen in situ at bone‐losing sites.
Yi Chen +12 more
wiley +1 more source
, 2007 乳癌對女性的健康造成極大的威脅。根據美國癌症協會的統計資料指出，婦女罹患乳癌的機率已攀升至31%；且致死率更升高為26%。而超過百分之六十的乳癌病患，歸類於雌激素-依賴性（estrogen -dependent）的乳癌。此類乳癌細胞中雌激素接受器α（Estrogen receptor α；ERα）有過量表現的情形，而且ERα在雌激素（17β-Estradiol；E2）的刺激下，會透過訊息傳遞以及ERα轉錄活性的增加，而促進乳癌細胞的增生與惡化。流行病學研究發現，富含多元不飽和脂肪酸DHA ...
呂怡芬, Lu, I-Fen
core
Cancer Nexus, EarlyView.ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang +4 more
wiley +1 more source