Results 21 to 30 of about 2,243,537 (271)

Expression patterns of STAT3, ERK and estrogen-receptor α are associated with development and histologic severity of hepatic steatosis: a retrospective study

Diagnostic Pathology, 2018
Background Hepatic steatosis renders hepatocytes vulnerable to injury, resulting in the progression of preexisting liver disease. Previous animal and cell culture studies implicated mammalian target of rapamycin (mTOR), signal transducer and activator of
Euno Choi, Won Kim, Sae Kyung Joo, Sunyoung Park, Jeong Hwan Park, Yun Kyung Kang, So-Young Jin, Mee Soo Chang   +7 more
doaj   +1 more source

Epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors [PDF]

Frontiers in Neuroscience, 2014
Estrogen action through estrogen receptor α (ERα) is involved in the control of sexual and social behaviors in adult mammals. Alteration of ERα gene activity mediated by epigenetic mechanisms, such as histone modifications and DNA methylation, in particular brain areas appears to be crucial for determining the extents of these behaviors between the ...
openaire   +3 more sources

Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra) [PDF]

, 2011
The roots of licorice (Glycyrrhiza glabra) are a rich source of flavonoids, in particular, prenylated flavonoids, such as the isoflavan glabridin and the isoflavene glabrene.
Vincken, J.P., Bovee, T.F.H., Luijendijk, T.J.C., Verbruggen, M.A., The, S.A.M., Mol, L.A.M., Simons, R., Gruppen, H.   +7 more
core   +1 more source

Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Although estrogen receptor α (ERα) acts primarily as a transcription factor, it can also elicit membrane‐initiated steroid signaling. Pharmacological tools and transgenic mouse models previously highlighted the key role of ERα membrane ...
Emmanuel Guivarc'h, Mélissa Buscato, Anne‐Laure Guihot, Julie Favre, Emilie Vessières, Linda Grimaud, Jamal Wakim, Nada‐Joe Melhem, Rana Zahreddine, Marine Adlanmerini, Laurent Loufrani, Claude Knauf, John A. Katzenellenbogen, Benita S. Katzenellenbogen, Jean‐Michel Foidart, Pierre Gourdy, Françoise Lenfant, Jean‐François Arnal, Daniel Henrion, Coralie Fontaine   +19 more
doaj   +1 more source

Lapatinib in the Treatment of Hormone Receptor-Positive/ErbB2-Positive Breast Cancer [PDF]

, 2010
In women with estrogen receptor(ER)- and ErbB2(HER2)-positive breast cancer, a vicious cycle is established between ER mechanisms of action and the growth factor receptor network, leading to enhanced cell proliferation and endocrine resistance.
Bauerfeind, Ingo, Elling, Dirk, Heinemann, Volker   +2 more
core   +1 more source

Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers [PDF]

, 2013
Introduction: We examined if a combination of proliferation markers and estrogen receptor (ER) activity could predict early versus late relapses in ER-positive breast cancer and inform the choice and length of adjuvant endocrine therapy.
Luca Gianni, Del Conte, Gianluca, Sotiriou, Christos, Pusztai, Lajos, Lajos Pusztai, Karn, Thomas, Symmans, W. Fraser, Libero Santarpia, Volkmar Müller, Santarpia, Libero, Sven Becker, Milvia Zambetti, Müller, Volkmar, Symmans, W Fraser, Benjamin Haibe-Kains, Kelly, Catherine M, Rody, Achim, Catherine M Kelly, Giampaolo Bianchini, Marcus Schmidt, Gianluca Del Conte, Gianni, Luca, Bianchini, Giampaolo, W Fraser Symmans, Haibe-Kains, Benjamin, Thomas Karn, Achim Rody, Schmidt, Marcus, Fasolo, Angelica, Takayuki Iwamoto, Angelica Fasolo, Holtrich, Uwe, Kelly, Catherine M., Yuan Qi, Christos Sotiriou, Uwe Holtrich, Iwamoto, Takayuki, Qi, Yuan, Becker, Sven, Zambetti, Milvia   +39 more
core   +2 more sources

MOESM1 of Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen related receptor β

, 2015
Additional file 1. Table S1: Known Hh-signaling pathway target genes. Table S2: Result of all pairwise comparisons of differentially expressed genes. Table S3: Hh-signaling differentially responsive genes.
Lu, Yuan, Li, Jilong, Cheng, Jianlin, Lubahn, Dennis   +3 more
openaire   +1 more source

MOESM2 of Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen related receptor β

, 2015
Additional file 2. Figure S1: Genes regulated by either Esrrb or Hh-signaling pathway. Figure S2: Decision tree model of gene sorting. Figure S3: Hh-responsive transcription-related genes. Figure S4: Correlation of qPCR and RNA-seq of top 15 Hh differentially responsive genes. Figure S5: Esrrb-dependent Hh-responsive genes.
Lu, Yuan, Li, Jilong, Cheng, Jianlin, Lubahn, Dennis   +3 more
openaire   +1 more source

Estrogen receptor β exhibited anti-tumor effects on osteosarcoma cells by regulating integrin, IAP, NF-kB/BCL-2 and PI3K/Akt signal pathway

Journal of Bone Oncology, 2017
This study aimed to investigate the effects of Estrogen receptor β (ERβ) on osteosarcoma cells, and explore the regulatory mechanisms involved in this process. Osteosarcoma U2-OS cells consisted four groups, and treated by E2, E2 + LY294002 (ERβ agonists), E2 + ERβ siRNA, E2 + ERβ siRNA + LY294002, respectively.
Minfei Yang, Bing Liu, Libin Jin, Huimin Tao, Zhengming Yang   +4 more
openaire   +3 more sources

Estrogen-dependent dynamic profile of eNOS-DNA associations in prostate cancer [PDF]

, 2013
In previous work we have documented the nuclear translocation of endothelial NOS (eNOS) and its participation in combinatorial complexes with Estrogen Receptor Beta (ERβ) and Hypoxia Inducible Factors (HIFs) that determine localized chromatin remodeling ...
Arturo Londono-Vallejo, Claudia Colussi (377816), Luis Jaime Castro-Vega (409816), Londono-Vallejo Arturo, Londono-Vallejo, Arturo, Simona Nanni, Colussi Claudia, Nanni, Simona, Pontecorvi, Alfredo, Castro-Vega, Luis Jaime, Carlo Gaetano (110837), Capogrossi, Maurizio C., Re, Agnese, Silvia Bacchetti (409817), Aiello Aurora, Valentina Benvenuti (409815), Guffanti Alessandro, Felsani, Armando, Claudia Colussi, Simona Nanni (110816), Maurizio C Capogrossi, Felsani Armando, Bacchetti, Silvia, Luis Jaime Castro-Vega, Benvenuti, Valentina, Armando Felsani (132772), Re Agnese, Pontecorvi Alfredo, Antonella Farsetti, Alessandro Guffanti, Gaetano, Carlo, Armando Felsani, Agnese Re, Castro-Vega Luis Jaime, Arturo Londono-Vallejo (5654743), Aurora Aiello, Nanni Simona, Alessandro Guffanti (5573), Maurizio C. Capogrossi (103525), Gaetano Carlo, Carlo Gaetano, Agnese Re (409814), Aurora Aiello (358824), Guffanti, Alessandro, Farsetti Antonella, Farsetti, Antonella, Capogrossi Maurizio C., Alfredo Pontecorvi, Alfredo Pontecorvi (409818), Antonella Farsetti (110827), Silvia Bacchetti, Aiello, Aurora, Benvenuti Valentina, Bacchetti Silvia, Colussi, Claudia, Valentina Benvenuti   +55 more
core   +2 more sources