MATH: A Deep Learning Approach in QSAR for Estrogen Receptor Alpha Inhibitors [PDF]
Molecules, 2023 Breast cancer ranks as the second leading cause of death among women, but early screening and self-awareness can help prevent it. Hormone therapy drugs that target estrogen levels offer potential treatments.
Rizki Triyani Pusparini +2 more
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Effects of Curcumin and Estrogen Receptor Alpha in Luminal Breast Cancer Cells [PDF]
DiagnosticsThis work examined the potential benefit of curcumin in breast cancer patients as a supplementary drug in ER-positive cancers. The results indicated that in the MCF-7 human breast cancer cell line, E2 and curcumin decreased cell proliferation and the ...
Lorena Palacios-Navarro +3 more
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AIB1/SRC-3/NCOA3 function in estrogen receptor alpha positive breast cancer [PDF]
Frontiers in Endocrinology, 2023 The estrogen receptor alpha (ERα) is a steroid receptor that is pivotal in the initiation and progression of most breast cancers. ERα regulates gene transcription through recruitment of essential coregulators, including the steroid receptor coactivator ...
Amber J. Kiliti +6 more
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Cadmium activation of wild-type and constitutively active estrogen receptor alpha [PDF]
Frontiers in EndocrinologyThe estrogen receptor alpha (ERα) plays a central role in the etiology, progression, and treatment of breast cancers. Constitutively activating somatic mutations Y537S and D538G, in the ligand binding domain (LBD) of ESR1, are associated with acquired ...
John B. Psaltis +7 more
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Estrogen receptor alpha regulates uterine epithelial lineage specification and homeostasis [PDF]
iScience, 2023 Summary: Postnatal development of the uterus involves specification of undifferentiated epithelium into uterine-type epithelium. That specification is regulated by stromal-epithelial interactions as well as intrinsic cell-specific transcription factors ...
Jason A. Rizo +4 more
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Frontiers in Pharmacology, 2023 Breast cancer is the most diagnosed type of cancer amongst women in economically developing countries and globally. Most breast cancers express estrogen receptor alpha (ERα) and are categorized as positive (ER+) breast cancer. Endocrine therapies such as,
Folasade R. Olayoku +2 more
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Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]
Pharmaceutical Sciences Asia, 2022 Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai +3 more
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Whole-genome cartography of estrogen receptor alpha binding sites. [PDF]
PLoS Genetics, 2007 Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7 breast cancer cells.
Chin-Yo Lin +22 more
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UJI IN SILICO SENYAWA 2,6-DIHIDROKSIANTRAQUINON SEBAGAI LIGAN PADA RESEPTOR ESTROGEN ALFA
Jurnal Farmasi Sains dan Komunitas, 2015 Previous studies has shown that estrogen receptor alpha that binds to estrogen may increase cancer cell proliferation, thus estrogen receptor alpha can be targeted to cure breast cancer.
Felicia Fraulein Setiawan +1 more
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Molecular docking of phytosterols in Stenochlaena palustris as anti-breast cancer
Acta Biochimica Indonesiana, 2021 Background: Stenochlaena palustris, also known as kelakai or lemidi, is frequently linked to anti-inflammatory, anti-bacterial, anti-fungal, and antioxidant properties. S. palustris phytosterols are suggested to suppress the progression of breast cancer.
Dona Marisa +4 more
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