Results 1 to 10 of about 82,886 (305)

Targeting Apoptosis Pathways in Cancer Therapy

Ca-A Cancer Journal for Clinicians, 2005
exaly  

Novel Agents on the Horizon for Cancer Therapy

Ca-A Cancer Journal for Clinicians, 2009
exaly  

Estrogen receptor alpha dynamics and plasticity during endocrine resistance [PDF]

Biology Direct
Background Breast cancer is subdivided into four distinct subtypes based on the status of hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) as HER2−/HR+, HER2+/HR+, HER2+/HR− and HER2−/HR−. Among this, ERα positive breast cancer,
Aswathy Sivasailam, Kiran S. Kumar, Aparna Geetha Jayaprasad, Shine Varghese Jancy, Ashwathi Harikumar, P. S. Unnikrishnan, K. C. Sivakumar, P. J. Jain Tiffee, Aman Munirpasha Halikar, S. S. Nithin, Prakash R. Pillai, Shivanshu Kumar Tiwari, Vishnu S. Sanjeev, A. V. Surabhi, T. R. Santhoshkumar   +14 more
doaj   +4 more sources

Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. [PDF]

PLoS ONE, 2009
While premature suture fusion, or craniosynostosis, is a relatively common condition, the cause is often unknown. Estrogens are associated with growth plate fusion of endochondral bones.
Aaron W James, Alexander A Theologis, Samantha A Brugmann, Yue Xu, Antoine L Carre, Philipp Leucht, Katherine Hamilton, Kenneth S Korach, Michael T Longaker   +8 more
doaj   +6 more sources

MATH: A Deep Learning Approach in QSAR for Estrogen Receptor Alpha Inhibitors [PDF]

Molecules, 2023
Breast cancer ranks as the second leading cause of death among women, but early screening and self-awareness can help prevent it. Hormone therapy drugs that target estrogen levels offer potential treatments.
Rizki Triyani Pusparini, Adila Alfa Krisnadhi, Firdayani   +2 more
doaj   +2 more sources

Effects of Curcumin and Estrogen Receptor Alpha in Luminal Breast Cancer Cells [PDF]

Diagnostics
This work examined the potential benefit of curcumin in breast cancer patients as a supplementary drug in ER-positive cancers. The results indicated that in the MCF-7 human breast cancer cell line, E2 and curcumin decreased cell proliferation and the ...
Lorena Palacios-Navarro, Leodan A. Crispin, Juan P. Muñoz, Gloria M. Calaf   +3 more
doaj   +2 more sources

Expression of Estrogen Receptor Alpha in Malignant Melanoma

Advanced Biomedical Research, 2017
Background: Features of malignant melanoma (MM) vary in the different geographic regions of the world. This may be attributable to environmental, ethnic, and genetic factors.
Parvin Rajabi, Marzieh Bagheri, Mohsen Hani   +2 more
doaj   +3 more sources

Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines [PDF]

BMC Cancer, 2009
Background Estrogen receptor-α (ERα) is essential for mammary gland development and is a major oncogene in breast cancer. Since ERα is not colocalized with the cell proliferation marker Ki-67 in the normal mammary glands and the majority of primary ...
Pan Zhongzong, Zhong Yili, Tan Huining
doaj   +3 more sources

Cadmium activation of wild-type and constitutively active estrogen receptor alpha [PDF]

Frontiers in Endocrinology
The estrogen receptor alpha (ERα) plays a central role in the etiology, progression, and treatment of breast cancers. Constitutively activating somatic mutations Y537S and D538G, in the ligand binding domain (LBD) of ESR1, are associated with acquired ...
John B. Psaltis, Qiaochu Wang, Gai Yan, Reem Gahtani, Nanxi Huang, Bassem R. Haddad, Mary Beth Martin, Mary Beth Martin   +7 more
doaj   +2 more sources

Estradiol accelerates liver regeneration through estrogen receptor α

Clinical and Experimental Gastroenterology, 2019
Yoji Tsugawa,1 Michiya Natori,2 Hiroshi Handa,3 Takeshi Imai11Department of Aging Intervention, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan; 2Department of Obstetrics and Gynecology, Tokyo Medical University, Shinjuku ...
Tsugawa Y, Natori M, Handa H, Imai T
doaj   +1 more source