Results 141 to 150 of about 121,912 (288)

Multiple Instance Learning with Coarse-to-Fine Self-Distillation [PDF]

open access: yesarXiv
Multiple Instance Learning (MIL) for whole slide image (WSI) analysis in computational pathology often neglects instance-level learning as supervision is typically provided only at the bag level. In this work, we present PathMIL, a framework designed to improve MIL through two perspectives: (1) employing instance-level supervision and (2) learning ...
arxiv  

Oxytocin Amplifies Negative Response to Ambiguity in Adolescent Females With and Without Eating Disorders

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Objective Eating disorders (ED) typically emerge in adolescence, a critical period for brain development and peer bonding. Interpersonal difficulties—particularly social anxiety—frequently co‐occur with ED. Oxytocin is a neuropeptide that modulates social cognition and linked to prosocial effects.
Victoria Burmester   +5 more
wiley   +1 more source

Development and Validation of Fully Automatic Deep Learning-Based Algorithms for Immunohistochemistry Reporting of Invasive Breast Ductal Carcinoma [PDF]

open access: yesarXiv
Immunohistochemistry (IHC) analysis is a well-accepted and widely used method for molecular subtyping, a procedure for prognosis and targeted therapy of breast carcinoma, the most common type of tumor affecting women. There are four molecular biomarkers namely progesterone receptor (PR), estrogen receptor (ER), antigen Ki67, and human epidermal growth ...
arxiv  

Molecular analysis of estrogen receptor alpha and beta in lupus patients [PDF]

open access: bronze, 2001
Eva Kassi   +4 more
openalex   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

open access: yesEnvironmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz   +9 more
wiley   +1 more source

Per‐ and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells

open access: yesEnvironmental Toxicology, Volume 38, Issue 1, Page 225-242, January 2023., 2023
Abstract Per‐ and polyfluoroalkyl substances (PFAS), which include perfluorooctanoic acid (PFOA), heptafluorobutyric acid (HFBA), and perfluorotetradecanoic acid (PFTA), are commonly occurring organic pollutants. Exposure to PFAS affects the immune system, thyroid and kidney function, lipid metabolism, and insulin signaling and is also involved in the ...
Qi Qi   +6 more
wiley   +1 more source

Cross-talk between Stat5b and estrogen receptor-alpha and -beta in mammary epithelial cells [PDF]

open access: bronze, 2001
Linda Björnström   +4 more
openalex   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

open access: yesEnvironmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers   +10 more
wiley   +1 more source

Effect of omega‐3 polyunsaturated fatty acid supplementation on oxidative stress parameters and sex hormone levels of modern genotype sows

open access: yesVeterinary Medicine and Science, Volume 9, Issue 1, Page 191-202, January 2023., 2023
In this study, we supplemented the diet of breeding sows either with omega‐6 (control) or omega‐3 (experimental) polyunsaturated fatty acids and examined their effects on the antioxidant system and hormone levels of the animals. In the blood levels of molecules indicating oxidative stress we experienced slight changes, but the feeding of omega‐3 fatty ...
Róbert Roszkos   +4 more
wiley   +1 more source

Activity of Benzo[a]pyrene and Its Hydroxylated Metabolites in an Estrogen Receptor-alpha Reporter Gene Assay

open access: bronze, 2000
Grantley D. Charles   +5 more
openalex   +1 more source

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