Results 201 to 210 of about 80,501 (258)

LncRNA PVT1 links estrogen receptor alpha and the polycomb repressive complex 2 in suppression of pro-apoptotic genes in hormone-responsive breast cancer. [PDF]

Cell Death Dis
Melone V, Palumbo D, Palo L, Brusco N, Salvati A, Tarallo A, Giurato G, Rizzo F, Nassa G, Weisz A, Tarallo R.   +10 more
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

RNA fine-tunes estrogen receptor-alpha binding on low-affinity DNA motifs for transcriptional regulation. [PDF]

EMBO J
Soota D, Saravanan B, Mann R, Kharbanda T, Notani D.   +4 more
europepmc   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

Association of Inflammation and Immune Cell Infiltration with Estrogen Receptor Alpha in an Estrogen and Ionizing Radiation-Induced Breast Cancer Model. [PDF]

Int J Mol Sci
Koning T, Calaf GM.
europepmc   +1 more source

Multiple eumenorrheic cycles are necessary to observe a significant increase in estrogen exposure and ovulation in exercising women with functional hypothalamic oligo/amenorrhea undergoing a nutritional intervention: Insights from the REFUEL study

PM&R, EarlyView.
Abstract Background Due to consequences of energy‐related oligo‐/amenorrhea (Oligo/Amen) among exercising females, recovery of menses (ROM) is a priority. ROM is inconsistently defined and rarely reported with reproductive hormone (estrogen, progesterone) data, making it difficult to know when females achieve adequate recovery. Objective The purpose of
Rebecca J. Mallinson, Nancy I. Williams, Emily A. Ricker, Heather C. M. Allaway, Mary Jane De Souza   +4 more
wiley   +1 more source

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

PM&R, EarlyView.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang, Qing Kuang, Cheng Chen, Binru Wang, Wei Xiang, Xinming Li, Jianjiao Mou   +6 more
wiley   +1 more source

Investigation of a Radio-Iodinated Alpha-Mangostin for Targeting Estrogen Receptor Alpha (ERα) in Breast Cancer: In Silico Design, Synthesis, and Biological Evaluation. [PDF]

Drug Des Devel Ther
Muchtaridi M, Nurhidayah W, Fakih TM, Kannaka K, Suzuki H, Subroto T, Uehara T.   +6 more
europepmc   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source