Results 211 to 220 of about 80,501 (258)

Deciphering estrogen receptor alpha-driven transcription in human endometrial stromal cells via transcriptome, cistrome, and integration with chromatin landscape. [PDF]

F S Sci
Montague Redecke SG, Bell-Hensley A, Li S, Yi M, Jain A, Massri AJ, DeMayo FJ.   +6 more
europepmc   +1 more source

Molecular and genomic advances in breast cancer: A comprehensive review of predictive and therapeutic innovations

Precision Medical Sciences, EarlyView.
Breast cancer subtypes, estrogen receptor‐positive (ER+), HER2‐enriched, and TNBC, are defined by genomic and epigenetic signatures. Multi‐omics profiling, immunotherapy, liquid biopsy, and AI‐driven radiogenomics enable precision medicine. Tools like Oncotype DX and PAM50 support personalized care.
Samina Malik, Arif Malik, Shahzad Ahmad, Hassan Mohsin, Shazia Iqbal   +4 more
wiley   +1 more source

Endosomal recycling inhibitors downregulate estrogen receptor-alpha and synergise with endocrine therapies. [PDF]

Breast Cancer Res Treat
Fletcher KA, Alkurashi MH, Lindsay AJ.
europepmc   +1 more source

Exploring the Gut‐Prostate Axis: Microbial Signatures Linked to Prostate Volume and Bladder Function

The Prostate, EarlyView.
ABSTRACT Background Benign prostatic hyperplasia (BPH) is a common urologic condition in aging men, often linked to systemic inflammation and metabolic dysfunction. Emerging evidence suggests that the gut microbiome may contribute to prostate health and disease.
Jonathan Surber, Marie Lork, Yasser Morsy, Michael Scharl, Daniel Stephan Engeler, Janine Langenauer, Lukas John Hefermehl, Anna Ebner, Basil Kaufmann, Manuela Hunziker, Daniel Eberli, Uwe Bieri, Cédric Poyet   +12 more
wiley   +1 more source

The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male-But Not Female-Rats to Enhance Short-Term Memory. [PDF]

J Neurosci
Mitchnick KA, Nicholson K, Wideman C, Jardine K, Jamieson-Williams R, Creighton SD, Lacoursiere A, Milite C, Castellano S, Sbardella G, MacLusky NJ, Choleris E, Winters BD.   +12 more
europepmc   +1 more source

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Transcriptional Suppression of the Estrogen Receptor by Truncated Estrogen Receptor-Alpha

Hormone and Metabolic Research, 2002
The estrogen receptor (ER) is composed of six major functional domains - the A/B domain as the activation function 1 domain, domain C as the DNA-binding domain, domain D as a hinge domain, and domain E/F as the ligand-dependent transcriptional domains. A novel protein (designated as SRB-RGS) that interacted with domains C and D of ER alpha (ER alpha C ...
M, Ikeda, M, Okai, T, Miyoshi, S, Tone, Y, Minatogawa   +4 more
openaire   +2 more sources

Estrogen receptors in urogenital schistosomiasis and bladder cancer: Estrogen receptor alpha-mediated cell proliferation

Urologic Oncology: Seminars and Original Investigations, 2020
Estrogen-like metabolites have been identified in S. haematobium, the helminth parasite that causes urogenital schistosomiasis (UGS) and in patients´ blood and urine during UGS. Estrogen receptor (ER) activation is enriched in the luminal molecular subtype bladder cancer (BlaCa). To date, the significance of ER to these diseases remains elusive.
Bernardo, Carina, Santos, Júlio, Costa, Céu, Tavares, Ana, Amaro, Teresina, Marques, Igor, Gouveia, Maria João, Félix, Vítor, Afreixo, Vera, Brindley, Paul J., Costa, José Manuel, Amado, Francisco, Helguero, Luisa, Santos, Lúcio L.   +13 more
openaire   +3 more sources

The multifunctional estrogen receptor-alpha F domain

Endocrine, 2008
The members of the nuclear receptor superfamily act as transcriptional regulatory factors and exhibit a multidomain structure characterized as domains A-E/F. This review focuses on a small, relatively understudied region at the extreme carboxy-terminus of the estrogen receptor (ER) alpha, the F domain.
Debra F, Skafar, Changqing, Zhao
openaire   +2 more sources

Photoperiod affects estrogen receptor alpha, estrogen receptor beta and aggressive behavior.

The European journal of neuroscience, 2007
Estrogens have important effects on male and female social behavior. Despite growing knowledge of the anatomy and behavioral effects of the two predominant estrogen receptor subtypes in mammals (ERalpha and ERbeta), relatively little is known about how these receptors respond to salient environmental stimuli. Many seasonally breeding species respond to
Brian C, Trainor, Michael R, Rowland, Randy J, Nelson   +2 more
openaire   +2 more sources