Results 221 to 230 of about 82,886 (305)

Investigating Lasofoxifene Efficacy Against the Y537S + F404V Double-Mutant Estrogen Receptor Alpha Using Molecular Dynamics Simulations. [PDF]

Bioinform Biol Insights
Bouricha EM, Hakmi M.
europepmc   +1 more source

Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

Obesity, EarlyView.
ABSTRACT Objective The real‐world evidence on the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and cancer risk remains limited and mixed. Methods In 2013–2020 national Medicare claims data, we included cancer‐naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP‐1 RA, sodium‐glucose cotransporter 2
Ying Lu, Hao Dai, Huilin Tang, William T. Donahoo, Thomas J. George, Ramon C. Sun, Sizun Jiang, Aik Choon Tan, Yi Guo, Jonathan D. Licht, John M. Allen, Kelvin P. Lee, Jingchuan Guo, Jiang Bian   +13 more
wiley   +1 more source

Rational evolution for altering the ligand preference of estrogen receptor alpha. [PDF]

Protein Sci
Eerlings R, Gupta P, Lee XY, Nguyen T, El Kharraz S, Handle F, Smeets E, Moris L, Devlies W, Vandewinkel B, Thiry I, Ta DT, Gorkovskiy A, Voordeckers K, Henckaerts E, Pinheiro VB, Claessens F, Verstrepen KJ, Voet A, Helsen C.   +19 more
europepmc   +1 more source

Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha , but not by ERbeta

, 1999
Jean‐Marc Vanacker
openalex   +1 more source

Synthesis of 1,2,3,4‐Tetrahydroisoquinoline‐3‐Carboxylic Acid‐Embedded Decapeptides: In Silico Studies and In Vitro Evaluation Against Breast Cancer

ChemistryOpen, EarlyView.
Synthesized decapeptides were designed and validated by in silico studies. They have significantly exhibited anticancer potential against breast cancer and MCF‐7 cell line. The above illustration specifies the synthetic pathway, biological screening, and the mode of action of the peptide in blocking the pathways responsible for the growth of cancer ...
Sunil Tivari, Naurin Lalani, Pritam Bagwe, Prashant Chandole, Ramesh Pawar, Enrique Delgado‐Alvarado, Abdallah Othman Ghnaim, Yashwantsinh Jadeja   +7 more
wiley   +1 more source

Female mice lacking membrane estrogen receptor alpha display impairments in spatial memory. [PDF]

Horm Behav
DeLarge AF, Stanley MJ, Daniel JM.
europepmc   +1 more source

Supplemental Figure 6 from Allele-specific gene regulation, phenotypes, and therapeutic vulnerabilities in estrogen receptor alpha mutant endometrial cancer

Zannel Blanchard, Craig M. Rush, Spencer Arnesen, Jeffery M. Vahrenkamp, Adriana C. Rodriguez, Elke A. Jarboe, Callie Brown, Matthew E.K. Chang, Mark R. Flory, Hisham Mohammed, Katarzyna Modzelewska, David H. Lum, Jason Gertz   +12 more
openalex   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Salivary gland protective and antiinflammatory effects of genistein in Sjögren's syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha. [PDF]

Cell Mol Biol Lett
Mao T, Wei W, Chen B, Chen Y, Liang S, Chen G, Liu Z, Wu X, Wu L, Li X, Watanabe N, Mayo KH, Pathak JL, Li J.   +13 more
europepmc   +1 more source

mRNA Expression of Cytochrome P450 17.ALPHA.hydroxylase, Cytochrome P450 Aromatase, Anti-Muellerian Hormone, Estrogen Receptor .ALPHA., and Androgen Receptor in Developing Gonads of Japanese Quail

, 2008
Keigo Nakamura, Kazumoto Shibuya, Noboru Saito, Kiyoshi Shimada, Atsushi Ohshima, Takuya Hirai, Tetsuo Nunoya   +6 more
openalex   +2 more sources