Results 261 to 270 of about 150,800 (299)
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Role of Estrogen Receptor Beta in Estrogen Action
Annual Review of Physiology, 2001▪ Abstract There was a time when the classification of sex hormones was simple. Androgens were male and estrogens female. What remains true today is that in young adults androgen levels are higher in males and estrogen levels higher in females. More recently we have learned that estrogens are necessary in males for regulation of male sexual behavior ...
K, Pettersson, J A, Gustafsson
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Estrogen receptor β: the antimechanostat?
Bone, 2005We have known for sometime that sex hormones influence the growth, preservation, and loss of bone tissue in the skeleton. However, we are only beginning to recognize how estrogen influences the responsiveness of the skeleton to exercise. Frost's mechanostat theory proposes that estrogen reduces the mechanical strain required to initiate an osteogenic ...
L K, Saxon, C H, Turner
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2002
When the discovery of ERβ was reported in 1996 [1], many endocrinologists thought that, since this receptor had gone unnoticed for so long, it must be some sort of vestigial receptor with no function in the endocrinology of estrogen. This idea was quickly dispelled when ERβ-/- mice were created and found to have severely compromised ovarian function ...
Zhang Weihua +5 more
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When the discovery of ERβ was reported in 1996 [1], many endocrinologists thought that, since this receptor had gone unnoticed for so long, it must be some sort of vestigial receptor with no function in the endocrinology of estrogen. This idea was quickly dispelled when ERβ-/- mice were created and found to have severely compromised ovarian function ...
Zhang Weihua +5 more
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Estrogen receptor alpha and beta in health and disease
Best Practice & Research Clinical Endocrinology & Metabolism, 2015Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors that are involved in the regulation of many complex physiological processes in humans. Abnormal ER signaling leads to development of a variety of diseases, such as cancer, metabolic and cardiovascular disease, neurodegeneration, inflammation, and osteoporosis.
Jia M, Dahlman-Wright K, Gustafsson JÅ
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Acta Histochemica, 2004
The endometrium expresses estrogen (ER) and progesterone receptors (PR), which are involved in autocrine and paracrine regulation processes in response to estrogen and progesterone. The aim of the present study was to evaluate immunohistochemical distribution patterns of estrogen receptor alpha (ER alpha), estrogen receptor beta (ER beta) and PR in ...
Udo Jeschke, Naim Shabani
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The endometrium expresses estrogen (ER) and progesterone receptors (PR), which are involved in autocrine and paracrine regulation processes in response to estrogen and progesterone. The aim of the present study was to evaluate immunohistochemical distribution patterns of estrogen receptor alpha (ER alpha), estrogen receptor beta (ER beta) and PR in ...
Udo Jeschke, Naim Shabani
exaly +3 more sources
Alfa and beta estrogen receptors and the biliary tree
Molecular and Cellular Endocrinology, 2002This manuscript summarizes recent data showing that estrogens and their receptors play an important role in modulating cholangiocyte proliferation. We have recently demonstrated that rat cholangiocytes express both estrogen receptors (ER)-alpha and -beta subtypes, while hepatocytes only express ER-alpha.
ALVARO, Domenico +8 more
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ESTROGEN RECEPTOR BETA TYPE IN THE RAT URINARY BLADDER
Archives of Andrology, 2006This study was conducted to localize estrogen receptor beta (ERbeta) in the rat urinary bladder respect to gender. The bladder dome and trigone of 16 Sprague Dawley rats (Male: 8, Female: 8) were evaluated utilizing the reverse transcriptase-polymerase chain reaction technique (RT-PCR) to detect ERbeta signal.
Eliçevik, Mehmet +4 more
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Estrogen receptor beta in breast cancer.
Endocrine-related cancer, 2002Estrogen is essential for normal growth and differentiation in the mammary gland. It also supports growth of approximately 50% of primary breast cancers. For this reason, removal of estrogen or blocking of its action with the anti-estrogen, tamoxifen, is the main treatment for estrogen receptor alpha (ERalpha)-positive tumors. In 1996, when oncologists
C, Palmieri +10 more
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Estrogen receptor β and breast cancer
European Journal of Surgical Oncology (EJSO), 2004A second estrogen receptor, estrogen receptor-beta, was identified in 1996 and has led to an intensive re-evaluation of the role of estrogens in normal physiological and disease processes. While much has been learnt about this new receptor, there remain many outstanding questions, particularly regarding its prognostic significance and therapeutic ...
P J, Balfe +3 more
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Challenging estrogen receptor β with phosphorylation
Trends in Endocrinology & Metabolism, 2010From classical gland-based endocrinology to nuclear hormone receptor biology, tremendous progress has been made in our understanding of hormone responses underlying cellular communication. Estrogen elicits a myriad of biological processes in reproductive and peripheral target tissues through its interaction with the estrogen receptors ERalpha and ...
Mélanie, Sanchez +3 more
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