Results 51 to 60 of about 154,423 (349)

Dopamine agonist and tamoxifen combination therapy for a prolactin-secreting pituitary tumor resistant to dopamine agonist monotherapy: Case report and review

Interdisciplinary Neurosurgery, 2020
Background: The majority of prolactin-secreting pituitary macroadenomas are effectively managed with dopamine-agonist therapy alone. Although surgical resection and radiotherapy are second- and third-line treatment options, there remains a paucity of ...
Zachary K. Christian, Kimmo J. Hatanpaa, Richard J. Auchus, Stephen R. Hammes, Ankur R. Patel, Bruce E. Mickey   +5 more
doaj   +1 more source

Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]

, 2014
Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright, David J. Rowlands, Dukes M, Girerd B, Josephine Fullerton, Kirsty M. Mair, Lynn Loughlin, Margaret Nilsen, Margaret R. MacLean, Martin J. Hussey, Matthew Thomas, Muxfeldt ES, Nicholas Duggan, Popovic RM, Silber DH, Sonia Roberts, Takahashi H, Teichmann J   +17 more
core   +1 more source

Detection of estrogen receptors ER-alpha and ER-beta in human ejaculated immature spermatozoa with excess residual cytoplasm

Reproductive Biology and Endocrinology, 2006
Background A key role of estrogens in human sperm biology has been recently suggested by aromatase and estrogen receptor detection in human testicular germ cells and ejaculated spermatozoa.
Aquila Saveria, Siciliano Laura, Rago Vittoria, Carpino Amalia   +3 more
doaj   +1 more source

Estrogen receptor beta treats Alzheimer's disease.

Neural regeneration research, 2013
In vitro studies have shown that estrogen receptor β can attenuate the cytotoxic effect of amyloid β protein on PC12 cells through the Akt pathway without estrogen stimulation. In this study, we aimed to observe the effect of estrogen receptor β in Alzheimer's disease rat models established by intraventricular injection of amyloid β protein.
Tian, Zhu, Fan, Jia, Zhao, Yang, Bi, Sheng, Si, Lihui, Liu, Qun   +5 more
openaire   +2 more sources

Estrogen Receptor-β Prevents Cardiac Fibrosis [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2010
Development of cardiac fibrosis portends the transition and deterioration from hypertrophy to dilation and heart failure. Here we examined how estrogen blocks this important development. Angiotensin II (AngII) and endothelin-1 induce cardiac hypertrophy and fibrosis in humans.
Ali, Pedram, Mahnaz, Razandi, Fiona, O'Mahony, Dennis, Lubahn, Ellis R, Levin   +4 more
openaire   +4 more sources

Androgen and estrogen receptor expression in the developing human penis and clitoris. [PDF]

, 2020
To better understand how the human fetal penis and clitoris grows and remodels, we undertook an investigation to define active areas of cellular proliferation and programmed cell death spatially and temporally during development of human fetal external ...
Baskin, Laurence, Cao, Mei, Cunha, Gerald R, Isaacson, Dylan, Li, Yi, Overland, Maya, Sinclair, Adriane   +6 more
core  

Ageing And Cancer As Diseases Of Epigenesis [PDF]

, 2009
Cancer and ageing are often said to be diseases of development. During the past fifty years, the genetic components of cancer and ageing have been intensely investigated since development, itself, was seen to be an epiphenomenon of the genome.
Gilbert, Scott F.
core   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Expression of estrogen and progesterone receptors in astrocytomas: a literature review

Clinics
Gliomas are the most common type of primary central nervous system neoplasm. Astrocytomas are the most prevalent type of glioma and these tumors may be influenced by sex steroid hormones.
Cléciton Braga Tavares, Francisca das Chagas Sheyla Almeida Gomes-Braga, Danylo Rafhael Costa-Silva, Carla Solange Escórcio-Dourado, Umbelina Soares Borges, Airton Mendes Conde-Junior, Maria da Conceição Barros-Oliveira, Emerson Brandão Sousa, Lorena da Rocha Barros, Luana Mota Martins, Gil Facina, Benedito Borges da-Silva   +11 more
doaj   +1 more source

Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth [PDF]

Osteoarthritis and Cartilage, 2014
Temporomandibular joint (TMJ) diseases predominantly afflict women, suggesting a role for female hormones in the disease process. However, little is known about the role of estrogen receptor (ER) signaling in regulating mandibular condylar cartilage growth.
Chen, J., Kamiya, Y., Polur, I., Xu, M., Choi, T., Kalajzic, Z., Drissi, H., Wadhwa, S.   +7 more
openaire   +2 more sources