Results 51 to 60 of about 71,407 (161)

Mammary Fat Can Adjust Prolactin Effect on Mammary Epithelial Cells via Leptin and Estrogen

International Journal of Endocrinology, 2009
Leptin, like estrogen, is one of the endo/paracrine factors, which are synthesized in and secreted from mature adipocytes. The roles of the mammary fat pad and mammary adipocytes in the initiation of lactation are not clear. In this study, we showed that
Yonatan Feuermann, Sameer J. Mabjeesh, Avi Shamay   +2 more
doaj   +1 more source

The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy

Biology of Sex Differences, 2017
Epidemiologic studies have previously suggested that premenopausal females have reduced incidence of cardiovascular disease (CVD) when compared to age-matched males, and the incidence and severity of CVD increases postmenopause.
Andrea Iorga, Christine M. Cunningham, Shayan Moazeni, Gregoire Ruffenach, Soban Umar, Mansoureh Eghbali   +5 more
doaj   +1 more source

Identification of pharmacophore synergism for optimization of estrogen receptor beta binders for hormone dependent forms of breast cancer

Chemical Physics Impact
Certain forms of breast cancer, particularly influenced by estrogen hormone, prompt the investigation of estrogen receptors as potential targets for therapeutic interventions.
Rania A. Hussien, Fatmah Ali S. Alasmary, Vijay H. Masand, Abdul Samad, Rahul D. Jawarkar, Gaurav S. Masand, Sami A. Al-Hussain, Magdi E.A. Zaki   +7 more
doaj   +1 more source

Gene expression of estrogen receptor during different stages of pregnancy in rats model [PDF]

Iraqi Journal of Veterinary Sciences
One essential organ that steroid hormones target is the uterus and ovaries. Many receptors mediate the effects of these hormones such as estrogen receptors ER.
Enas O. Al-Babily, Barra D. Al-Watar
doaj   +1 more source

Pancreatic insulin content regulation by the estrogen receptor ER alpha.

PLoS ONE, 2008
The function of pancreatic beta-cells is the synthesis and release of insulin, the main hormone involved in blood glucose homeostasis. Estrogen receptors, ER alpha and ER beta, are important molecules involved in glucose metabolism, yet their role in ...
Paloma Alonso-Magdalena, Ana B Ropero, M Pilar Carrera, Christopher R Cederroth, Mathurin Baquié, Benoit R Gauthier, Serge Nef, Enrico Stefani, Angel Nadal   +8 more
doaj   +1 more source

Pituitary Action of E2 in Prepubertal Grass Carp: Receptor Specificity and Signal Transduction for Luteinizing Hormone and Follicle-Stimulating Hormone Regulation

Frontiers in Endocrinology, 2018
17β-estradiol (E2) is an important sex steroid produced by ovary and brain. In mammals, E2 plays an important role in hypothalamus–pituitary–gonad axis to regulate puberty onset, however, little is known about the functional role of E2 in teleost ...
Xiangfeng Qin, Yaqian Xiao, Cheng Ye, Jingyi Jia, Xiangjiang Liu, Hongwei Liang, Guiwei Zou, Guangfu Hu   +7 more
doaj   +1 more source

17α-Ethynyl-5α-androstane-3α, 17β-diol Treatment of MNU-Induced Mammary Cancer in Rats

International Journal of Breast Cancer, 2011
N-methyl-N-nitrosourea (MNU) induces estrogen-dependent mammary tumors in female Lewis rats. We explored the antineoplastic activity of a synthetic androstane derivative, 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235), as a single agent or in ...
Clarence N. Ahlem, James M. Frincke, Steven K. White, Christopher L. Reading, Richard J. Trauger, Rajkumar Lakshmanaswamy   +5 more
doaj   +1 more source

Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes

Reproductive Biology and Endocrinology, 2011
Background Estrogen signaling is mediated by estrogen receptor beta isoforms in normal and neoplastic human testes. Recently, a G-protein-coupled-receptor (GPER) has been suggested as being involved in rapid responses to estrogens in different normal and
Maggiolini Marcello, Giordano Francesca, Romeo Francesco, Rago Vittoria, Carpino Amalia   +4 more
doaj   +1 more source

Beta 3 Adrenergic Receptor Activation Rescues Metabolic Dysfunction in Female Estrogen Receptor Alpha-Null Mice

Frontiers in Physiology, 2019
Metabolic disease risk escalates following menopause. The mechanism is not fully known, but likely involves reduced signaling through estrogen receptor alpha (ERα), which is highly expressed in brown and white adipose tissue (BAT and WAT).Objective: Test
Stephanie L. Clookey, Rebecca J. Welly, Dusti Shay, Makenzie L. Woodford, Kevin L. Fritsche, R. Scott Rector, R. Scott Rector, R. Scott Rector, Jaume Padilla, Jaume Padilla, Jaume Padilla, Dennis B. Lubahn, Victoria J. Vieira-Potter   +12 more
doaj   +1 more source

Evaluation of (Z)-endoxifen as a potential therapy for glioblastoma multiforme through computational and experimental analyses

Scientific Reports
(Z)-endoxifen (endoxifen) is the active metabolite of tamoxifen. Endoxifen is a potent antiestrogen that binds and blocks estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ).
Anastasia Shneyderman, Sandra S. Hammer, H. Lawrence Remmel, Alexander Veviorskiy, Khadija M. Alawi, Alina Ustiugova, Mikhail Korzinkin, Alex Zhavoronkov, Steven C. Quay   +8 more
doaj   +1 more source