Results 11 to 20 of about 1,982 (172)

Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene

Microbiology Spectrum, 2022
Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC.
Jawara Allen, Axel Rosendahl Huber, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Shaoguang Wu, Xinqun Wu, Charelle Boot, Aurelia Saftien, Heather M. O’Hagan, Hao Wang, Ruben van Boxtel, Hans Clevers, Cynthia L. Sears   +12 more
doaj   +4 more sources

The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice [PDF]

iScience, 2023
Summary: The gut microbiota in early childhood is linked to asthma risk, but may continue to affect older patients with asthma. Here, we profile the gut microbiota of 38 children (19 asthma, median age 8) and 57 adults (17 asthma, median age 28) by 16S ...
Naomi G. Wilson, Ariel Hernandez-Leyva, Anne L. Rosen, Natalia Jaeger, Ryan T. McDonough, Jesus Santiago-Borges, Michael A. Lint, Thomas R. Rosen, Christopher P. Tomera, Leonard B. Bacharier, S. Joshua Swamidass, Andrew L. Kau   +11 more
doaj   +3 more sources

Quantitative profiling of colorectal cancer-associated bacteria reveals associations between fusobacterium spp., enterotoxigenic Bacteroides fragilis (ETBF) and clinicopathological features of colorectal cancer.

PLoS ONE, 2015
Various studies have presented clinical or in vitro evidence linking bacteria to colorectal cancer, but these bacteria have not previously been concurrently quantified by qPCR in a single cohort.
Katie S Viljoen, Amirtha Dakshinamurthy, Paul Goldberg, Jonathan M Blackburn   +3 more
doaj   +5 more sources

Contribution of genetic and environmental factors to obesity indices and their overlap. [PDF]

Diabetes Obes Metab
Abstract Aims Numerous indices have been developed to quantify obesity and the distribution of body fat; however, none are sufficient alone, and combined usage is complicated by their potential intercorrelation. This study aims to quantify genetic and environmental influences on anthropometric measures, 12 derived obesity indices and the extent of ...
Ani A, Nolte IM, Vaez A, Snieder H.
europepmc   +2 more sources

Modeling ETBF-Mediated Colorectal Tumorigenesis Using AOM/DSS in Wild-Type Mice. [PDF]

Int J Mol Sci
Enterotoxigenic Bacteroides fragilis (ETBF) promotes colitis-associated cancer through the Bacteroides fragilis toxin (BFT), which induces colonic inflammation that can be exacerbated by external stimuli. We found that BALB/c mice infected with ETBF and treated with azoxymethane and dextran sodium sulfate (DSS) developed numerous distal colon polyps ...
Hwang S, Lee Y, Rhee KJ.
europepmc   +2 more sources

Dietary Salt Administration Decreases Enterotoxigenic Bacteroides fragilis (ETBF)-Promoted Tumorigenesis via Inhibition of Colonic Inflammation [PDF]

International Journal of Molecular Sciences, 2020
Consumption of a Western-type diet has been linked to gut-microbiota-mediated colon inflammation that constitutes a risk factor for colorectal cancer. A high salt diet (HSD) exacerbates IL-17A-induced inflammation in inflammatory bowel disease and other autoimmune diseases.
Soonjae Hwang, Hye Chin Yi, Samnoh Hwang, Minjeong Jo, Ki-Jong Rhee   +4 more
openaire   +2 more sources

Protective Effects of Zerumbone on Colonic Tumorigenesis in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized AOM/DSS BALB/c Mice [PDF]

International Journal of Molecular Sciences, 2020
Chronic inflammation has been linked to colitis-associated colorectal cancer in humans. The human symbiont enterotoxigenic Bacteroides fragilis (ETBF), a pro-carcinogenic bacterium, has the potential to initiate and/or promote colorectal cancer. Antibiotic treatment of ETBF has shown promise in decreasing colonic polyp formation in murine models of ...
Soonjae Hwang, Minjeong Jo, Ju Eun Hong, Chan Oh Park, Chang Gun Lee, Ki-Jong Rhee   +5 more
openaire   +2 more sources

Case-control study on the role of enterotoxigenic Bacteroides fragilis as a cause of diarrhea among children in Kolkata, India. [PDF]

PLoS ONE, 2013
A total of 874 fecal specimens (446 diarrheal cases and 428 controls) from diarrheal children admitted in the Infectious Diseases Hospital, Kolkata and age and sex matched asymptomatic subjects from an urban community were assessed for the prevalence of ...
Dharanidharan Ramamurthy, Gururaja P Pazhani, Anirban Sarkar, Ranjan K Nandy, Krishnan Rajendran, Dipika Sur, Bamkesh Manna, Thandavarayan Ramamurthy   +7 more
doaj   +1 more source

Enterotoxigenic Bacteroides fragilis activates IL-8 expression through Stat3 in colorectal cancer cells

Gut Pathogens, 2022
Background Enterotoxigenic Bacteroides fragilis (ETBF) has been implicated in colorectal carcinogenesis through the actions of its toxin, B. fragilis toxin (BFT).
Rachel V. Purcell, Jessica Permain, Jacqueline I. Keenan   +2 more
doaj   +1 more source

G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis

Communications Biology, 2021
Boleij et al. show that G protein-coupled receptor 35 (GPR35) regulates the responses to enterotoxigenic Bacteroides fragilis (ETBF) in colonic epithelial cells.
Annemarie Boleij, Payam Fathi, William Dalton, Ben Park, Xinqun Wu, David Huso, Jawara Allen, Sepideh Besharati, Robert A. Anders, Franck Housseau, Amanda E. Mackenzie, Laura Jenkins, Graeme. Milligan, Shaoguang Wu, Cynthia L. Sears   +14 more
doaj   +1 more source