Results 1 to 10 of about 4,746 (159)
Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes
Angewandte Chemie International Edition, Volume 62, Issue 46, November 13, 2023., 2023 We investigated the incorporation of equatorial ligands into platinum(IV) complexes, enabling the synthesis of otherwise unavailable complexes. Attachment of albumin‐targeting maleimide moieties led to increased tumor accumulation and anticancer activity compared to oxaliplatin. The presented strategy will allow the development of new types of targeted
Alexander Kastner +5 more
wiley +1 more source
Medicinal Research Reviews, Volume 43, Issue 6, Page 2260-2302, November 2023., 2023 Abstract Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease in which the motor neuron circuitry displays progressive degeneration, affecting mostly the motor neurons in the brain and in the spinal cord. There are no effective cures, albeit three drugs, riluzole, edaravone, and AMX0035 (a combination of sodium phenylbutyrate ...
Mohamed F. Elmansy +4 more
wiley +1 more source
Clinical Pharmacology in Drug Development, Volume 12, Issue 10, Page 966-978, October 2023., 2023 Abstract Futibatinib, a selective, irreversible fibroblast growth factor receptor 1–4 inhibitor, is being investigated for tumors harboring FGFR aberrations and was recently approved for the treatment of FGFR2 fusion/rearrangement‐positive intrahepatic cholangiocarcinoma.
Ikuo Yamamiya +7 more
wiley +1 more source
Acute effect of prednisolone on renal handling of sodium. [PDF]
, 1973 The effect of prednisolone on renal handling of sodium (Na) was studied in rats under three experimental conditions: 1) hydropenia, 2) water diuresis, and 3) distal tubular blockade (DTB).
Halgrimson, CG +3 more
core +1 more source
Hetero-Bis-Conjugation of Bioactive Molecules to Half-Sandwich Ruthenium(II) and Iridium(III) Complexes Provides Synergic Effects in Cancer Cell Cytotoxicity [PDF]
, 2021 Four bipyridine-Type ligands variably derivatized with two bioactive groups (taken from ethacrynic acid, flurbiprofen, biotin, and benzylpenicillin) were prepared via sequential esterification steps from commercial 2,2′-bipyridine-4,4′-dicarboxylic acid ...
Batchelor L. K. +9 more
core +1 more source
Insecticide resistance compromises the control of Aedes aegypti in Bangladesh
Pest Management Science, Volume 79, Issue 8, Page 2846-2861, August 2023., 2023 Phenotypic characterization of insecticide resistance was conducted using an adaptation of the CDC bottle bioassay on 3‐ to 5‐day‐old, non‐blood‐fed female F1 mosquitoes. Abstract BACKGROUND With no effective drugs or widely available vaccines, dengue control in Bangladesh is dependent on targeting the primary vector Aedes aegypti with insecticides and
Hasan Mohammad Al‐Amin +8 more
wiley +1 more source
Inhibitors of bacterial and plants urease [PDF]
, 2013 Urease is an important virulence factor for Helicobacter pylori and Proteus mirabilis as well as in environmental transformations of certain nitrogenous compounds.
Macegoniuk, Katarzyna
core +1 more source
Deafness induces complete crossmodal plasticity in a belt region of dorsal auditory cortex
European Journal of Neuroscience, Volume 58, Issue 4, Page 3058-3073, August 2023., 2023 Activity of neurons in the higher‐order auditory area DZ of hearing and early‐deaf cats were collected in response to different unisensory and multisensory stimuli. In hearing cats, almost all neurons responded to auditory stimuli and a considerable number of neurons (more than 76%) responded to visual stimuli.
Yaser Merrikhi +4 more
wiley +1 more source
Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer [PDF]
, 2016 Epidermal growth factor receptor (EGFR) inhibitors such as erlotinib are novel effective agents in the treatment of EGFR-driven lung cancer, but their clinical impact is often impaired by acquired drug resistance through the secondary T790M EGFR mutation.
Chater, E +13 more
core +2 more sources
In Situ Nitric Oxide Gas Nanogenerator Reprograms Glioma Immunosuppressive Microenvironment
Advanced Science, Volume 10, Issue 18, June 23, 2023., 2023 Sphingosine‐1‐phosphate modified liposomes are designed for the delivery of the chemotherapeutic drug temozolomide and nitric oxide prodrug to glioma cells. Nitric oxide produced in tumor cells enhances tumor immunogenicity by inducing immunogenic cell death, and activates the killing effect of temozolomide by inhibiting cellular autophagy.
Yang Liu +8 more
wiley +1 more source