Improvement of the Chemical Reactivity of Michael Acceptor of Ethacrynic Acid Correlates with Antiproliferative Activities [PDF]
Molecules, 2023 The present study aims to report the design, synthesis, and biological activity of new ethacrynic acid (EA) analogs (6–10) obtained by the double modulation of the carboxylic acid moiety and the aromatic ring with the aim to increase the chemical ...
Abdelmoula El Abbouchi +8 more
doaj +4 more sources
Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug [PDF]
Viruses, 2021 In 2019 an outbreak occurred which resulted in a global pandemic. The causative agent has been identified in a virus belonging to the Coronaviridae family, similar to the agent of SARS, referred to as SARS-CoV-2.
Camilla Isgrò +2 more
doaj +4 more sources
Ethacrynic acid is an inhibitor of human factor XIIIa [PDF]
BMC Pharmacology and Toxicology, 2022 Background Ethacrynic acid (EA) is a loop diuretic that is approved orally and parenterally to manage edema-associated diseases. Nevertheless, it was earlier reported that it is also associated with bleeding upon its parenteral administration.
Srabani Kar +3 more
doaj +2 more sources
Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus [PDF]
Clinics, 2018 OBJECTIVES: Several compounds characterized by an olefin linkage conjugated to a carbonyl group have anti-inflammatory properties. The diuretic ethacrynic acid (EA) is a compound of this type.
Tomoyuki Harada +2 more
doaj +2 more sources
Design, Synthesis, Computational Studies, and Anti-Proliferative Evaluation of Novel Ethacrynic Acid Derivatives Containing Nitrogen Heterocycle, Urea, and Thiourea Moieties as Anticancer Agents [PDF]
MoleculesIn the present work, the synthesis of new ethacrynic acid (EA) derivatives containing nitrogen heterocyclic, urea, or thiourea moieties via efficient and practical synthetic procedures was reported.
Abdelmoula El Abbouchi +8 more
doaj +2 more sources
Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. [PDF]
PLoS ONE, 2009 BACKGROUND:Aberrant activation of Wnt/beta-catenin signaling promotes the development of several cancers. It has been demonstrated that the Wnt signaling pathway is activated in chronic lymphocytic leukemia (CLL) cells, and that uncontrolled Wnt/beta ...
Desheng Lu +8 more
doaj +2 more sources
Identification of glutathione transferase (GST P1) inhibitors via a high-throughput screening assay and implications as alternative treatment options for breast cancers. [PDF]
PLoS ONEGlutathione S-transferase P1-1 (GST P1) is an important drug target as it is implicated in drug resistance. GST P1-1 inhibitors are typically non-productive analogues of glutathione which covers broad chemical space; hence it is likely that several ...
Sarah A P Pereira +5 more
doaj +2 more sources
Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes. [PDF]
Protein Cell, 2021 Cui Z +21 more
europepmc +3 more sources
Furosemide versus ethacrynic acid in pediatric patients undergoing cardiac surgery: a randomized controlled trial. [PDF]
Crit Care, 2015 Ricci Z +5 more
europepmc +3 more sources