Results 41 to 50 of about 57,905 (241)

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

Citizenship pressure and knowledge hiding: The mediating role of citizenship fatigue and the moderating role of supervisor–subordinate guanxi

, 2023
International audienceDrawing on conservation of resources (COR) theory, we examine the relationship between citizenship pressure and knowledge hiding, exploring the underlying mechanism between the two through citizenship fatigue and supervisor ...
Hongdan Zhao, Cuiling Jiang, Tung‐Ju Wu, Wenzhi Zheng, Zheng, W., Wu, T.-J., Peixu He, Zhao, H., Jiang, C., He, P.   +9 more
core   +1 more source

Impostor leader and knowledge hiding: Attachment avoidance as underlying mechanism

Acta Psychologica
Impostorism and knowledge-hiding behaviors negatively impact employees and organizational performance. This study examines the association between impostor leaders and knowledge hiding (evasive hiding, playing dumb, and rationalized hiding).
Laibin Wang, Muhammad Waseem Bari, Sadia Shaheen, Kaiyang Zhong   +3 more
doaj   +1 more source

CoSP: Reconfigurable Metamaterial Inverse Design via Contrastive Pretrained Large Language Model

Advanced Science, EarlyView.
In this work, CoSP (contrastive multi‐state pretrain), an intelligent inverse design method for reconfigurable metamaterials based on a contrastive pretrained large language model, is proposed. Numerical experiments demonstrate that CoSP can design reconfigurable metamaterial structures for multi‐state, multi‐band optical responses, showing great ...
Shujie Yang, Yuqi Zhang, Xuzhe Zhao, Yansong Tang, Kaichen Dong   +4 more
wiley   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Leader's envy and knowledge hiding in universities in Pakistan [PDF]

, 2021
The present study examines the role of the leader's envy in knowledge hiding. Based on 28 semi-structured interviews from the faculty members of different Universities in Pakistan, we explain that how leader's perception of relative power as compare to ...
Ali, Moazzam, Pham, Tan Nhat, Usman, Muhammad   +2 more
core   +1 more source

Hiding Places: The Architecture of Survival

, 2020
“Hiding Places. The Architecture of Survival” is an article that summarizes the preliminary stage of my artistic studies on the architecture of hiding places.
Natalia Romik
core   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Survey of Bio-inspired Computing for Information Hiding

, 2016
In this paper, we performed surveys of bio-inspired techniques for information hiding. The applications of bio-inspired optimization for information hiding or watermarking have emerged in early 2000's.
Huang, Hsiang-Cheh;Chang, Feng-Cheng;Chen, Yueh-Hong;Chu, Shu-Chuan
core   +1 more source