Results 101 to 110 of about 287,814 (315)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Event-Triggered Fuzzy-Networked Control System for a 3-DOF Quadcopter with Limited-Bandwidth Communication

Applied System Innovation
Quadcopters are attracting widespread attention due to their growing demand for use in various applications. Since wired communication would severely restrict a quadcopter’s range, maneuverability, and applications, quadcopters usually communicate via ...
Ti-Hung Chen
doaj   +1 more source

Periodic event-triggered control of nonlinear systems using overapproximation techniques

, 2018
In event-triggered control, the control task consisting of sampling the plant's output and updating the control input is executed whenever a certain event function exceeds a given threshold. The event function typically needs to be monitored continuously,
Heemels, W.P.M.H., Tabuada, Paulo, D.P. Borgers, Nešić, D., Nešić, D, Postoyan, Romain, Anta, A, Anta, A., Postoyan, R., P. Tabuada, D. Nešić, W.P.M.H. Heemels, Tabuada, P., Heemels, WPMH Maurice, A. Anta, Borgers, D.P., Borgers, DP Niek, R. Postoyan   +17 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Event-triggered proportional-derivative control for nonlinear network systems with a novel event-triggering scheme: Differential of triggered state consideration

Advances in Mechanical Engineering, 2017
This article proposes event-triggered proportional-derivative control for a class of nonlinear network control systems. For derivative action of the proposed proportional-derivative control, a novel event-triggering scheme is devised together with the ...
Baeyoung Koo, Wookyong Kwon, Sangmoon Lee, Chongsoo Lee   +3 more
doaj   +1 more source

Decentralized event-triggered control with asynchronous updates

IEEE Conference on Decision and Control and European Control Conference, 2011
We propose taking event-triggered control actions to implement decentralized control over wireless sensor/actuator networks without requiring synchronized measurement updates. In comparison with the existing results on event-triggered decentralized control, the proposed implementation does not rely on weak coupling between subsystems, nor does it ...
Manuel Mazo Jr. 0002, Ming Cao 0001
openaire   +2 more sources

Time-regularized and periodic event-triggered control for linear systems

, 2018
In this chapter, we provide an overview of our recent results for the analysis and design of Event-Triggered controllers that are tailored to linear systems as provided in Heemels et al., IEEE Trans Autom Control 58(4):847–861, 2013, Heemels et al., IEEE
Teel, A.R., Heemels, W.P.M.H., Dolk, V.S., Tarbouriech, Sophie, Borgers, D.P., Dullerud, G.E., Girard, Antoine, Hetel, Laurentiu   +7 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Discrete-Time Event-Triggered Control of Nonlinear Wireless Networked Control Systems

Abstract and Applied Analysis, 2014
This paper investigates the problem of stabilization of nonlinear discrete-time networked control systems (NCSs) with event-triggering communication scheme in the presence of signal transmission delay.
Songlin Hu, Dong Yue, Min Shi, Xiangpeng Xie   +3 more
doaj   +1 more source

Data-Driven Dynamic Event-Triggered Control

IEEE Transactions on Automatic Control
This paper revisits the event-triggered control problem from a data-driven perspective, where unknown continuous-time linear systems subject to disturbances are taken into account. Using data information collected off-line instead of accurate system model information, a data-driven dynamic event-triggered control scheme is developed in this paper.
Tao Xu 0058, Zhiyong Sun 0001, Guanghui Wen, Zhisheng Duan   +3 more
openaire   +3 more sources