Excitatory amino acid antagonists for acute stroke [PDF]
Cochrane Database of Systematic Reviews, 2003 Focal cerebral ischaemia causes release of excitatory amino acid (EAA) neurotransmitters, principally glutamate, with resultant over-stimulation of EAA receptors and downstream pathways. Excess glutamate release is a pivotal event in the evolution of irreversible ischaemic damage in animal models of ischaemia, and drugs that modulate glutamate action ...
Keith W. Muir, Kennedy R. Lees
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Excitatory Amino-Acid Antagonists and Their Possible Clinical Application
CHIMIA, 1991 A brief review of the pharmacology of some excitatory amino-acid receptor antagonists, active at the N-methyl-D-aspartate receptor subtype, and prospects of their possible therapeutic indication are given.
Peter Frey
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Effects of excitatory amino acid antagonists on evoked and spontaneous excitatory potentials in guinea‐pig hippocampus. [PDF]
The Journal of Physiology, 1986 Evoked and spontaneous excitatory post‐synaptic potentials (e.p.s.p.s) at the mossy fibre input to CA3 pyramidal neurones were recorded intracellularly in slices from the guinea‐pig hippocampus. The effects of several amino acid antagonists on these responses were examined. L‐2‐amino‐4‐phosphonobutyrate (L‐AP4), L‐serine‐O‐phosphate (L‐SOP), kynurenate,
Carl W. Cotman +3 more
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A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurones of the isolated spinal cord of the rat [PDF]
British Journal of Pharmacology, 1987 1 The potency of 7 excitatory amino acid antagonists has been measured at kainate receptors on primary afferent C fibres using isolated dorsal roots from immature rats.
Richard H. Evans +3 more
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Effects of some excitatory amino acid antagonists and drugs enhancing gamma-aminobutyric acid neurotransmission on pefloxacin-induced seizures in DBA/2 mice [PDF]
Antimicrobial Agents and Chemotherapy, 1997 The behavioral and convulsant effects of pefloxacin (PEFLO), a quinolone derivative, were studied after intraperitoneal (i.p.) administration to Dilute Brown Agouti DBA/2J (DBA/2) mice, a strain genetically susceptible to sound-induced seizures.
Giovambattista De Sarro +3 more
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Excitatory amino acid antagonists and their potential for the treatment of ischaemic brain damage in man. [PDF]
British Journal of Clinical Pharmacology, 1992 1. A wide range of therapeutic strategies has been explored in humans and experimental animals with the aim of improving outcome after brain ischaemia but few have shown convincing clinical benefit. 2.
James McCulloch
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Comparison of s‐ and κ‐ opiate receptor ligands as excitatory amino acid antagonists [PDF]
, 1984 1 Using the technique of microelectrophoresis in pentobarbitone‐anaesthetized cats and rats, the effects of benzomorphans, with known actions at s‐ and κ‐ opioid receptors, were tested on responses of spinal neurones to amino acids and acetylcholine.
Stephen C. Berry +2 more
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Excitatory amino acid antagonists and endogenous aspartate and glutamate release from rat hippocampal slices [PDF]
British Journal of Pharmacology, 1988 1 The effect of excitatory amino acid agonists and antagonists on the efflux of endogenous aspartate and glutamate from the rat hippocampus in vitro was studied.
J.H. Connick, Trevor W. Stone
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Effects of excitatory amino acid antagonists on the phasic depolarizing events that occur in lumbar motoneurons during REM periods of active sleep [PDF]
Journal of Neuroscience, 1995 The membrane potential of lumbar motoneurons is dominated during the tonic periods of active sleep by glycine-mediated inhibitory postsynaptic potentials (IPSPs). During the phasic rapid eye movement (REM) periods of active sleep there are also IPSPs but,
PJ Soja +3 more
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Administration of Excitatory Amino Acid Antagonists via Microdialysis Attenuates the Increase in Glucose Utilization Seen following Concussive Brain Injury [PDF]
Journal of Cerebral Blood Flow and Metabolism, 1992 Tatsuro Kawamata +4 more
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