Excitatory amino acid antagonists for acute stroke [PDF]
Cochrane Database of Systematic Reviews, 2003 Focal cerebral ischaemia causes release of excitatory amino acid (EAA) neurotransmitters, principally glutamate, with resultant over-stimulation of EAA receptors and downstream pathways. Excess glutamate release is a pivotal event in the evolution of irreversible ischaemic damage in animal models of ischaemia, and drugs that modulate glutamate action ...
Keith W. Muir, Kennedy R. Lees
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Excitatory Amino-Acid Antagonists and Their Possible Clinical Application
CHIMIA, 1991 A brief review of the pharmacology of some excitatory amino-acid receptor antagonists, active at the N-methyl-D-aspartate receptor subtype, and prospects of their possible therapeutic indication are given.
Peter Frey
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Action of excitatory amino acids and their antagonists on hippocampal neurons
Cellular and Molecular Neurobiology, 1985 Intracellular recordings were obtained from guinea pig hippocampal neurons maintained in vitro. Current- and voltage-clamp techniques were used to study the effect of microiontophoresis of excitatory amino acid agonists. Modification of agonist responses by bath application of known concentrations of antagonist agents was also examined.
John J. Hablitz
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Effects of excitatory amino acid antagonists on the phasic depolarizing events that occur in lumbar motoneurons during REM periods of active sleep [PDF]
Journal of Neuroscience, 1995 The membrane potential of lumbar motoneurons is dominated during the tonic periods of active sleep by glycine-mediated inhibitory postsynaptic potentials (IPSPs). During the phasic rapid eye movement (REM) periods of active sleep there are also IPSPs but,
PJ Soja +3 more
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Effects of excitatory amino acid antagonists on evoked and spontaneous excitatory potentials in guinea‐pig hippocampus. [PDF]
Journal of Physiology, 1986 Carl W. Cotman +3 more
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A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurones of the isolated spinal cord of the rat [PDF]
British Journal of Pharmacology, 1987 Richard H. Evans +3 more
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Administration of Excitatory Amino Acid Antagonists via Microdialysis Attenuates the Increase in Glucose Utilization Seen following Concussive Brain Injury [PDF]
Journal of Cerebral Blood Flow and Metabolism, 1992 Tatsuro Kawamata +4 more
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Comparison of s‐ and κ‐ opiate receptor ligands as excitatory amino acid antagonists [PDF]
, 1984 Stephen C. Berry +2 more
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Effects of some excitatory amino acid antagonists and drugs enhancing gamma-aminobutyric acid neurotransmission on pefloxacin-induced seizures in DBA/2 mice [PDF]
Antimicrobial Agents and Chemotherapy, 1997 Giovambattista De Sarro +3 more
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Excitatory amino acid antagonists and their potential for the treatment of ischaemic brain damage in man. [PDF]
British Journal of Clinical Pharmacology, 1992 James McCulloch
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