Results 11 to 20 of about 402 (78)

G-protein coupled estrogen receptor (GPER1) activation promotes synaptic insertion of AMPA receptors and induction of chemical LTP at hippocampal temporoammonic-CA1 synapses

Molecular Brain, 2023
It is well documented that 17β estradiol (E2) regulates excitatory synaptic transmission at hippocampal Shaffer-collateral (SC)-CA1 synapses, via activation of the classical estrogen receptors (ERα and ERβ).
Leigh Clements, Amy Alexander, Kirsty Hamilton, Andrew Irving, Jenni Harvey   +4 more
doaj   +1 more source

Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats. [PDF]

PLoS ONE, 2012
Although in vivo evidence indicates that salsolinol, the condensation product of acetaldehyde and dopamine, has properties that may contribute to alcohol abuse, the underlying mechanisms have not been fully elucidated.
Guiqin Xie, Jiang-Hong Ye
doaj   +1 more source

Modulation of glutamate transport and receptor binding by glutamate receptor antagonists in EAE rat brain. [PDF]

PLoS ONE, 2014
The etiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. The elevation of glutamate in cerebrospinal fluid, as well as changes in the expression of glutamate receptors ...
Grzegorz Sulkowski, Beata Dąbrowska-Bouta, Elżbieta Salińska, Lidia Strużyńska   +3 more
doaj   +1 more source

An Insight into Animal Glutamate Receptors Homolog of Arabidopsis thaliana and Their Potential Applications—A Review

Plants, 2022
Most excitatory impulses received by neurons are mediated by ionotropic glutamate receptors (iGluRs). These receptors are located at the apex and play an important role in memory, neuronal development, and synaptic plasticity.
Ruphi Naz, Andleeb Khan, Badrah S. Alghamdi, Ghulam Md Ashraf, Maimonah Alghanmi, Altaf Ahmad, Sheikh Shanawaz Bashir, Qazi Mohd Rizwanul Haq   +7 more
doaj   +1 more source

Unique Features of Network Bursts Emerge From the Complex Interplay of Excitatory and Inhibitory Receptors in Rat Neocortical Networks

Frontiers in Cellular Neuroscience, 2019
Spontaneous network activity plays a fundamental role in the formation of functional networks during early development. The landmark of this activity is the recurrent emergence of intensive time-limited network bursts (NBs) rapidly spreading across the ...
Heidi Teppola, Jugoslava Aćimović, Marja-Leena Linne   +2 more
doaj   +1 more source

Amino acids in the vitreous and intravitreal fluid in rhegmatogenous retinal detachment patients with different proliferative vitreoretinopathy grades

Journal of Ophthalmology, 2015
Background:Proliferative vitreoretinopathy (PVR) is known to worsen the treatment prognosis of rhegmatogenous retinal detachment (RRD) and to result in irreversible loss of vision due to apoptotic or necrotic process in retinal neurons. Some studies have
G.V. Levitskaya
doaj   +1 more source

Opioid Tolerance and Physical Dependence: Role of Spinal Neuropeptides, Excitatory Amino Acids and Their Messengers

Pain Research and Management, 2000
Chronic opioid treatment results in the development of tolerance and physical dependence. The mechanisms underlying opioid tolerance and/or physical dependence are unclear.
Khem Jhamandas, Kelly Powell, Remi Quirion, B Milne   +3 more
doaj   +1 more source

AMPA GluA1-flip targeted oligonucleotide therapy reduces neonatal seizures and hyperexcitability.

PLoS ONE, 2017
Glutamate-activated α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA-Rs) mediate the majority of excitatory neurotransmission in brain and thus are major drug targets for diseases associated with hyperexcitability or neurotoxicity ...
Nicole M Lykens, David J Coughlin, Jyoti M Reddi, Gordon J Lutz, Melanie K Tallent   +4 more
doaj   +1 more source

Blockade of Glutamate Receptors within the Prelimbic Cortex Attenuate Concentration of Excitatory Amino Acids in the Morphine Self-administration in Rats

Advanced Biomedical Research, 2018
Background: The attitude of research on addiction has been done on the key role of glutamate. As a regard, the prelimbic cortex (PrL) has an important role in addiction, learning, and memory.
Fateme Aboutalebi, Hojjatallah Alaei, Shahrbanoo Oryan   +2 more
doaj   +1 more source

Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation

BMC Neuroscience, 2013
Background Domoic acid (DA) is an excitatory amino acid analogue of kainic acid (KA) that acts via activation of glutamate receptors to elicit a rapid and potent excitotoxic response, resulting in neuronal cell death.
Tsunekawa Koji, Kondo Fumio, Okada Teruhiko, Feng Guo-Gang, Huang Lei, Ishikawa Naohisa, Okada Shoshiro   +6 more
doaj   +1 more source