Results 11 to 20 of about 44,335 (335)
Excitatory Amino-Acid Antagonists and Their Possible Clinical Application
CHIMIA, 1991 A brief review of the pharmacology of some excitatory amino-acid receptor antagonists, active at the N-methyl-D-aspartate receptor subtype, and prospects of their possible therapeutic indication are given.
Peter Frey
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Excitatory amino acid antagonists for acute stroke [PDF]
Cochrane Database of Systematic Reviews, 2003 Focal cerebral ischaemia causes release of excitatory amino acid (EAA) neurotransmitters, principally glutamate, with resultant over-stimulation of EAA receptors and downstream pathways. Excess glutamate release is a pivotal event in the evolution of irreversible ischaemic damage in animal models of ischaemia, and drugs that modulate glutamate action ...
Keith W. Muir, Kennedy R. Lees
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Glial Activation, Neuroinflammation, and Loss of Neuroprotection in Chronic Pain: Cellular Mechanisms and Emerging Therapeutic Strategies [PDF]
BiomedicinesChronic pain is increasingly regarded as a condition of glia–neuronal dysregulation driven by persistent neuroinflammatory signaling. Following injury to nerves or tissues, glial cells, including astrocytes or satellite glial cells, undergo changes in ...
Alyssa McKenzie +4 more
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Action of excitatory amino acids and their antagonists on hippocampal neurons
Cellular and Molecular Neurobiology, 1985 Intracellular recordings were obtained from guinea pig hippocampal neurons maintained in vitro. Current- and voltage-clamp techniques were used to study the effect of microiontophoresis of excitatory amino acid agonists. Modification of agonist responses by bath application of known concentrations of antagonist agents was also examined.
John J. Hablitz
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The Role of Glutamate Receptors in Epilepsy
Biomedicines, 2023 Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen +3 more
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Frontiers in Cell and Developmental Biology, 2023 Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission and are implicated in various neurological disorders. In this review, we discuss the role of the two fastest iGluRs subtypes, namely, α-amino-3-hydroxy-5-methyl ...
Marina N. Vukolova +5 more
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Neuroprotection, excitotoxicicity and nmda antagonists [PDF]
Arquivos de Neuro-Psiquiatria, 2000 PURPOSE: To analyze the main aspects of neuroprotection and excitotoxicity. DISCUSSION: This is a significant theory on the pathophysiology of cerebral ischemia; it is based on the release of excitatory aminoacid (EAA), mainly glutamate.
RUBENS JOSÉ GAGLIARDI
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The effects of angiotensin II and angiotensin-(1-7) in the rostral ventrolateral medulla of rats on stress-induced hypertension. [PDF]
PLoS ONE, 2013 We have shown that angiotensin II (Ang II) and angiotensin-(1-7) [Ang-(1-7)] increased arterial blood pressure (BP) via glutamate release when microinjected into the rostral ventrolateral medulla (RVLM) in normotensive rats (control).
Dongshu Du +9 more
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Biomolecules, 2022 L-Glutamic acid is the main excitatory neurotransmitter in the central nervous system (CNS). Its associated receptors localized on neuronal and non-neuronal cells mediate rapid excitatory synaptic transmission in the CNS and regulate a wide range of ...
Elena A. Golubeva +3 more
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Biomedicines, 2023 Status epilepticus (SE) is a neurological emergency with a high mortality rate. When compared to chronic epilepsy, it is distinguished by the durability of seizures and frequent resistance to benzodiazepine (BZD).
Tzu-Hsin Huang +3 more
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