Results 11 to 20 of about 43,942 (341)

Interaction of hypothalamic GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors controlling heart rate in rats [PDF]

open access: yes, 1991
We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to ...
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

α-Lipoic Acid Derivatives as Allosteric Modulators for Targeting AMPA-Type Glutamate Receptors’ Gating Modules

open access: yesCells, 2022
The ionotropic glutamate receptor subtype α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) is responsible for most excitatory transmission in the brain.
Mohammad Qneibi   +3 more
doaj   +1 more source

Hypothalamic excitatory amino acid receptors mediate stress-induced tachycardia in rats [PDF]

open access: yes, 1992
The role of hypothalamic excitatory amino acid (EAA) receptors in mediating the cardiovascular response to stress was examined using conscious chronically instrumented rats.
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

Effect of excitatory and inhibitory agents and a glial inhibitor on optically-recorded primary-afferent excitation

open access: yesMolecular Pain, 2008
The effects of GABA, excitatory amino-acid receptors antagonists and a glial metabolism inhibitor on primary-afferent excitation in the spinal dorsal horn were studied by imaging the presynaptic excitation of high-threshold afferents in cord slices from ...
Murase Kazuyuki   +2 more
doaj   +1 more source

Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition

open access: yesAnnals of Clinical and Translational Neurology, 2020
Objective The amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) is increasingly recognized as a therapeutic target in drug‐refractory pediatric epilepsy.
Sukhvir K. Wright   +9 more
doaj   +1 more source

Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats. [PDF]

open access: yesPLoS ONE, 2012
Although in vivo evidence indicates that salsolinol, the condensation product of acetaldehyde and dopamine, has properties that may contribute to alcohol abuse, the underlying mechanisms have not been fully elucidated.
Guiqin Xie, Jiang-Hong Ye
doaj   +1 more source

Interaction of GABA and Excitatory Amino Acids in the Basolateral Amygdala: Role in Cardiovascular Regulation [PDF]

open access: yes, 1997
Activation of the amygdala in rats produces cardiovascular changes that include increases in heart rate and arterial pressure as well as behavioral changes characteristic of emotional arousal.
Cook, Jennifer C.   +3 more
core   +2 more sources

G-protein coupled estrogen receptor (GPER1) activation promotes synaptic insertion of AMPA receptors and induction of chemical LTP at hippocampal temporoammonic-CA1 synapses

open access: yesMolecular Brain, 2023
It is well documented that 17β estradiol (E2) regulates excitatory synaptic transmission at hippocampal Shaffer-collateral (SC)-CA1 synapses, via activation of the classical estrogen receptors (ERα and ERβ).
Leigh Clements   +4 more
doaj   +1 more source

GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors in dorsomedial hypothalamus and heart rate in rats [PDF]

open access: yes, 1991
We have previously shown that microinjection of drugs that interfere with the function of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) into the hypothalamus produces cardiorespiratory and behavioral changes resembling those seen in ...
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

Modulation of glutamate transport and receptor binding by glutamate receptor antagonists in EAE rat brain. [PDF]

open access: yesPLoS ONE, 2014
The etiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. The elevation of glutamate in cerebrospinal fluid, as well as changes in the expression of glutamate receptors ...
Grzegorz Sulkowski   +3 more
doaj   +1 more source

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