Results 221 to 230 of about 43,942 (341)

Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia. [PDF]

Transl Psychiatry
Olivares-Berjaga D, Martínez-Pinteño A, Rodríguez N, Mas S, Morén C, Parellada E, Gassó P.   +6 more
europepmc   +1 more source

Protective compunds in animal models of trigeminal activation and neurodegeneration [PDF]

, 2009
Vámos Enikő
core  

A Silk Fibroin Nanoparticle Hydrogel Loaded With NK1R Antagonist Has Synergistic Anti‐Inflammatory and Reparative Effects on Dry Eye Disease

Advanced Science, EarlyView.
This study develops a silk fibroin (SF) nanoparticles hydrogel targeting neurokinin 1 receptor with CP‐99994 (CP). Combining CP and SF to form stable nanoparticles while incorporating a flexible hydrogel material results in a sustained‐release ophthalmic drop formulation (SF@CP@Gel), which provides a long‐lasting ophthalmic formulation with anti ...
Bo Gong, Yi Liu, Huan Li, Xueming Ju, Dongfeng Li, Yuhao Zou, Xiaoxin Guo, Kai Dong, Jialing Xiao, Weijia Wu, Renjie Chai, Ruifan Zhang, Man Yu   +12 more
wiley   +1 more source

N-methyl-D-aspartate Receptors and Depression: Linking Psychopharmacology, Pathology and Physiology in a Unifying Hypothesis for the Epigenetic Code of Neural Plasticity. [PDF]

Pharmaceuticals (Basel)
Comai S, De Martin S, Mattarei A, Guidetti C, Pappagallo M, Folli F, Alimonti A, Manfredi PL.   +7 more
europepmc   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Effects of excitatory amino acid antagonists on morphine-induced scratching in mice

, 1997
Tsukasa Sakurada, Chikai Sakurada, Akinori Sugiyama, Koichi Tan‐No   +3 more
openalex   +1 more source

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication

Advanced Science, EarlyView.
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He, Kai Yuan, Junming Pan, Shaoping Weng, Chaozheng Li, Yihong Chen, Jianguo He   +6 more
wiley   +1 more source

Disrupted glutamate homeostasis as a target for glioma therapy. [PDF]

Pharmacol Rep
Biegański M, Szeliga M.
europepmc   +1 more source

From Lab to Life: Self‐Powered Sweat Sensors and Their Future in Personal Health Monitoring

Advanced Science, EarlyView.
This review focuses on recent advances in self‐powered sweat sensors in personal health monitoring, including sweat sensors, energy harvesters, energy management, and their applications. It analyzes the difficulties and challenges in the research field of self‐powered sweat sensors and looks into the future direction of self‐powered sweat sensors from ...
Nan Gao, Guodong Xu, Gang Chang, Yuxiang Wu   +3 more
wiley   +1 more source

The Role of Glutamate and Blood-Brain Barrier Disruption as a Mechanistic Link between Epilepsy and Depression. [PDF]

Cells
Gruenbaum BF, Schonwald A, Boyko M, Zlotnik A.   +3 more
europepmc   +1 more source