Results 1 to 10 of about 308,176 (159)
Imperfect space clamp permits electrotonic interactions between inhibitory and excitatory synaptic conductances, distorting voltage clamp recordings. [PDF]
PLoS ONE, 2011 The voltage clamp technique is frequently used to examine the strength and composition of synaptic input to neurons. Even accounting for imperfect voltage control of the entire cell membrane ("space clamp"), it is often assumed that currents measured at ...
Alon Poleg-Polsky, Jeffrey S Diamond
doaj +8 more sources
Acute application of Centella asiatica extract enhanced AMPAR-mediated postsynaptic currents in rat entorhinal cortex [PDF]
Journal of Integrative Neuroscience, 2020 Centella asiatica is notable for its wide range of biological activities beneficial to human health, particularly its cognitive enhancement and neuroprotective effects.
Jia Hui Wong, Faruque Reza, Sangu Muthuraju, Huei Gau Chuang, Jingli Zhang, Mohd Harizal Senik, Siti Rafidah Yusof, Habsah Mohamad, Tengku Sifzizul Tengku Muhammad, Nor Hadiani Ismail, Jafri Malin Abdullah
doaj +1 more source
Impact of the activation rate of the hyperpolarization-activated current $I_{\rm h}$ on the neuronal membrane time constant and synaptic potential duration [PDF]
Eur. Phys. J. Spec. Top. (2021), 2021 The temporal dynamics of membrane voltage changes in neurons is controlled by ionic currents. These currents are characterized by two main properties: conductance and kinetics. The hyperpolarization-activated current ($I_{\rm h}$) strongly modulates subthreshold potential changes by shortening the excitatory postsynaptic potentials and decreasing their
arxiv +1 more source
Frontiers in Neuroscience, 2023 IntroductionN-methyl-D-aspartate receptor (NMDAR) is one of the main receptor of the excitatory neurotransmitter glutamate in the brain, which is the key determinant of the excitatory/inhibitory balance of neural network.
Teng Zhao +7 more
doaj +1 more source
Neuropsychopharmacology Reports, 2023 Binge‐like exposure to ethanol during the brain growth spurt triggers apoptotic neurodegeneration in multiple brain regions, including the retrosplenial cortex, a brain region that is part of the hippocampal‐diencephalic‐cingulate memory network. This is
Clark W. Bird, Carlos F. Valenzuela
doaj +1 more source
eLife, 2020 In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum.
Andreas Hoehne +2 more
doaj +1 more source
Membrane-derived phospholipids control synaptic neurotransmission and plasticity. [PDF]
PLoS Biology, 2015 Synaptic communication is a dynamic process that is key to the regulation of neuronal excitability and information processing in the brain. To date, however, the molecular signals controlling synaptic dynamics have been poorly understood.
Victoria García-Morales +8 more
doaj +1 more source
Frontiers in Synaptic Neuroscience, 2022 Synaptic plasticity is a critical process that regulates neuronal activity by allowing neurons to adjust their synaptic strength in response to changes in activity.
Caitlyn A. Chapman +2 more
doaj +1 more source
Hyperpolarization following activation of K+ channels by excitatory postsynaptic potentials [PDF]
Nature, 1983 We have postulated that an excitatory postsynaptic potential (e.p.s.p.) may open voltage-sensitive K+ ('M') channels, in an appropriate depolarizing range, and that this could alter the e.p.s.p. waveform. Consequently, the fast e.p.s.p. in neurones of sympathetic ganglia, elicited by a nicotinic action of acetylcholine (ACh), could be followed by a ...
Tsuneo Tosaka +3 more
openaire +3 more sources
Visualization by high resolution immunoelectron microscopy of the transient receptor potential vanilloid-1 at inhibitory synapses of the mouse dentate gyrus. [PDF]
PLoS ONE, 2015 We have recently shown that the transient receptor potential vanilloid type 1 (TRPV1), a non-selective cation channel in the peripheral and central nervous system, is localized at postsynaptic sites of the excitatory perforant path synapses in the ...
Miren-Josune Canduela +7 more
doaj +1 more source