Results 11 to 20 of about 179,338 (253)

Recurrent excitatory postsynaptic potentials induced by synchronized fast cortical oscillations [PDF]

open access: greenProceedings of the National Academy of Sciences, 1997
Gamma frequency (about 20–70 Hz) oscillations occur during novel sensory stimulation, with tight synchrony over distances of at least 7 mm. Synchronization in the visual system has been proposed to reflect coactivation of different parts of the visual field by a single spatially extended object.
Miles A. Whittington   +4 more
semanticscholar   +5 more sources

A Simple Mathematical Model of Second-Messenger Mediated Slow Excitatory Postsynaptic Potentials

open access: greenJournal of Computational Neuroscience, 2000
We have developed a novel and simple mathematical model of a slow excitatory postsynaptic potential (EPSP) based on an abstraction of the processes of activation, inactivation, and summation of a cAMP, protein kinase A (PKA)-dependent second-messenger cascade.
Paul Bertrand   +3 more
semanticscholar   +6 more sources

Active summation of excitatory postsynaptic potentials in hippocampal CA3 pyramidal neurons [PDF]

open access: greenProceedings of the National Academy of Sciences, 1998
The manner in which the thousands of synaptic inputs received by a pyramidal neuron are summed is critical both to our understanding of the computations that may be performed by single neurons and of the codes used by neurons to transmit information. Recent work on pyramidal cell dendrites has shown that subthreshold synaptic inputs are modulated by ...
Nathaniel N. Urban, Germán Barrionuevo
openalex   +4 more sources

γ-Hydroxybutyrate inhibits excitatory postsynaptic potentials in rat hippocampal slices

open access: hybridEuropean Journal of Pharmacology, 1999
Gamma-Hydroxybutyrate (GHB) has been shown to mimic different central actions of ethanol, to suppress alcohol withdrawal syndrome, and to reduce alcohol consumption both in rats and in humans. The aim of the present study was to determine if GHB shared with alcohol the ability to inhibit glutamate action at both NMDA and AMPA/kainate receptors.
Fulvia Berton   +6 more
openalex   +5 more sources

Transcranial focused ultrasound induces sustained synaptic plasticity in rat hippocampus

open access: yesBrain Stimulation, 2022
Transcranial focused ultrasound (tFUS) neuromodulation provides a promising emerging non-invasive therapy for the treatment of neurological disorders.
Xiaodan Niu, Kai Yu, Bin He
doaj   +1 more source

Efavirenz restored NMDA receptor dysfunction and inhibited epileptic seizures in GluN2A/Grin2a mutant mice

open access: yesFrontiers in Neuroscience, 2023
IntroductionN-methyl-D-aspartate receptor (NMDAR) is one of the main receptor of the excitatory neurotransmitter glutamate in the brain, which is the key determinant of the excitatory/inhibitory balance of neural network.
Teng Zhao   +7 more
doaj   +1 more source

The positive allosteric modulator of NMDA receptors, GNE‐9278, blocks the ethanol‐induced decrease of excitability in developing retrosplenial cortex neurons from mice

open access: yesNeuropsychopharmacology Reports, 2023
Binge‐like exposure to ethanol during the brain growth spurt triggers apoptotic neurodegeneration in multiple brain regions, including the retrosplenial cortex, a brain region that is part of the hippocampal‐diencephalic‐cingulate memory network. This is
Clark W. Bird, Carlos F. Valenzuela
doaj   +1 more source

Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex

open access: yeseLife, 2020
In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum.
Andreas Hoehne   +2 more
doaj   +1 more source

Membrane-derived phospholipids control synaptic neurotransmission and plasticity. [PDF]

open access: yesPLoS Biology, 2015
Synaptic communication is a dynamic process that is key to the regulation of neuronal excitability and information processing in the brain. To date, however, the molecular signals controlling synaptic dynamics have been poorly understood.
Victoria García-Morales   +8 more
doaj   +1 more source

The Yin and Yang of GABAergic and Glutamatergic Synaptic Plasticity: Opposites in Balance by Crosstalking Mechanisms

open access: yesFrontiers in Synaptic Neuroscience, 2022
Synaptic plasticity is a critical process that regulates neuronal activity by allowing neurons to adjust their synaptic strength in response to changes in activity.
Caitlyn A. Chapman   +2 more
doaj   +1 more source

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