Results 41 to 50 of about 83,508 (337)

Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat [PDF]

, 2004
Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and ...
Candelario-Jalil, Eduardo, Fiebich, Bernd L., García-Cabrera, Michel, González-Falcón, Armando, León, Olga S.   +4 more
core   +1 more source

Nonmulberry Silk Fibroin Doping Boosts Charge Transfer and Charge Injection in Aligned Polypyrrole‐Silk Scaffolds for Low‐Voltage Neurostimulation

Advanced Materials Interfaces, EarlyView.
Conductive silk‐polypyrrole scaffolds couple redox stability with cell‐affinitive peptides present innately in an endogenous silk fibroin, enabling optimized electrical stimulation to drive neurite outgrowth. Findings establish electrochemical‐biological link for biomaterial design rules for smart nerve guidance conduits that can provide low voltage ...
Rajiv Borah, Joseph Christakiran Moses, Jnanendra Upadhyay, Jitu Mani Das, Michael G. Monaghan, Biman B. Mandal   +5 more
wiley   +1 more source

Excitotoxicity-Associated p53 Expression in Adult Rat Retina Is Mediated by Calpain Activity but Not by Cl− Influx

Journal of Pharmacological Sciences, 2009
.: We have previously demonstrated an important role of influx of Cl− rather than Ca2+ in acute excitotoxicity in adult rat retina. As p53 has been implicated in delayed apoptotic cell death, here we examined the appearance of p53 immunoreactivity in a ...
Yasuhiro Hama, Hiroshi Katsuki, Yasuhiko Izumi, Toshiaki Kume, Akinori Akaike   +4 more
doaj   +1 more source

The Redox Biology of Excitotoxic Processes: The NMDA Receptor, TOPA Quinone, and the Oxidative Liberation of Intracellular Zinc

Frontiers in Neuroscience, 2020
This special issue of Frontiers in Neuroscience-Neurodegeneration celebrates the 50th anniversary of John Olney’s seminal work introducing the concept of excitotoxicity as a mechanism for neuronal cell death.
Elias Aizenman, Ralph H. Loring, Ian J. Reynolds, Paul A. Rosenberg   +3 more
doaj   +1 more source

Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics [PDF]

, 2018
Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available ...
Anderton, Ryan S, Knuckey, Neville W, MacDougall, Gabriella, Mastaglia, Frank L, Meloni, Bruno P   +4 more
core   +1 more source

Long‐Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury

Advanced Science, EarlyView.
Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti, Edwige Rice, Franck Desmoulin, Maylis Combeau, Mélissa Parny, Lorenne Robert, Etienne Buscail, Barbara Bournet, Nathalie Vergnolle, Isabelle Raymond‐Letron, Isabelle Loubinoux, Carla Cirillo   +11 more
wiley   +1 more source

Enriched environment inhibits GLT-1 ubiquitination by downregulating SMURF1 to attenuate ischemic brain injury induced excitotoxicity

Cell & Bioscience
Background Excitotoxicity induced by glutamate contributes significantly to ischemic brain injury. The role of enriched environment (EE) in promoting neurological recovery post-stroke is well-established, yet its impact on excitotoxicity remains unclear.
Yi Zhang, Wen Liu, Tao Huang, Lingling Liu, Xiuping Chen   +4 more
doaj   +1 more source

Revisiting Excitotoxicity in Traumatic Brain Injury: From Bench to Bedside

Pharmaceutics, 2022
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality. Consequences vary from mild cognitive impairment to death and, no matter the severity of subsequent sequelae, it represents a high burden for affected patients and for ...
Daniela Baracaldo-Santamaría, Daniel Felipe Ariza-Salamanca, María Gabriela Corrales-Hernández, Maria José Pachón-Londoño, Isabella Hernandez-Duarte, Carlos-Alberto Calderon-Ospina   +5 more
doaj   +1 more source

Pathologically Activated Neuroprotection via Uncompetitive Blockade of \u3cem\u3eN\u3c/em\u3e-Methyl-d-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin [PDF]

, 2010
Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists with fast off-rate (UFO) may represent promising drug candidates for various neurodegenerative disorders.
Fu, Hongjun, Han, Yifan, Huang, Pingbo, Li, Chaoying, Li, Fushun, Li, Wenming, Luo, Jialie, Ma, Dik-Lung, Pang, Yuanping, Peoples, Robert W., Tang, Jing, Wang, Qinwen, Xia, Jun, Zhao, Yuming   +13 more
core   +1 more source

Therapeutic potential of co-enzyme Q10 in retinal diseases [PDF]

, 2017
Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain.
Marcheggiani, Fabio, Reilly, James, Shu, Xinhua, Tiano, Luca, Tohari, Ali Mohammad, Zhang, Xun, Zhou, Xinzhi   +6 more
core   +1 more source