Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury. [PDF]
, 2019 AimThe activation of the TNFR2 receptor is beneficial in several pathologies of the central nervous system, and this study examines whether it can ameliorate the recovery process following spinal cord injury.MethodsEHD2-sc-mTNFR2 , an agonist specific ...
Bethea, John R +10 more
core +2 more sources
The fate of interneurons, GABAA receptor sub‐types and perineuronal nets in Alzheimer's disease
Brain Pathology, Volume 33, Issue 1, January 2023., 2023 Abstract Alzheimer's disease (AD) is the most common neurological disease, which is associated with gradual memory loss and correlated with synaptic hyperactivity and abnormal oscillatory rhythmic brain activity that precedes phenotypic alterations and is partly responsible for the spread of the disease pathology.
Afia B. Ali +2 more
wiley +1 more source
Excitotoxicity and Neuroprotection
The Journal of Clinical Psychiatry, 1997 Issue: Excitatory neurotransmission is a normal physiologic process mediated by the neurotransmitter glutamate. Too much glutamate release can be destructive and literally excite a neuron to death in a process called excitotoxicity. Blocking this process may be neuroprotective and prevent brain disorders mediated by excitotoxicity.
openaire +5 more sources
Targeting Polyamine Oxidase to Prevent Excitotoxicity-Induced Retinal Neurodegeneration
Frontiers in Neuroscience, 2019 Dysfunction of retinal neurons is a major cause of vision impairment in blinding diseases that affect children and adults worldwide. Cellular damage resulting from polyamine catabolism has been demonstrated to be a major player in many neurodegenerative ...
Prahalathan Pichavaram +20 more
doaj +1 more source
NMDA receptor antagonists as potential therapy in cerebellar degenerative disorders
Анналы клинической и экспериментальной неврологии, 2022 Cerebellar degeneration remains a poorly studied topic. Excitotoxicity, i.e. neuronal damage and death due to excess activation of postsynaptic N-methyl-D-aspartate receptors (NMDAR) by glutamate, is considered to be a universal mechanism of most ...
Olga S. Belozor +3 more
doaj +1 more source
FTY720 attenuates excitotoxicity and neuroinflammation [PDF]
Journal of Neuroinflammation, 2015 FTY720 (fingolimod, Gilenya™), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy has been related to induced lymphopenia and consequent immunosuppression via modulation of S1P1 receptors (S1P1R).
Cipriani, Raffaela +3 more
openaire +4 more sources
Frontiers in Molecular Neuroscience, 2018 Excessive dynamin related protein 1 (Drp1)-triggered mitochondrial fission contributes to apoptosis under pathological conditions and therefore it has emerged as a promising therapeutic target.
A. Ruiz, E. Alberdi, C. Matute
semanticscholar +1 more source
FGF-2 Induces Neuronal Death through Upregulation of System xc- [PDF]
, 2014 The cystine/glutamate antiporter (system xc-) transports cystine into cell in exchange for glutamate. Fibroblast growth factor-2 (FGF-2) upregulates system xc- selectively on astrocytes, which leads to increased cystine uptake, the substrate for ...
Albano, Rebecca +2 more
core +1 more source
A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation. [PDF]
, 2020 BackgroundInteractions between neurons, astrocytes, and microglia critically influence neuroinflammatory responses to insult in the central nervous system.
Goshi, Noah +3 more
core
CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]
, 2016 BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus +5 more
core +1 more source