Results 71 to 80 of about 95,867 (358)
Advanced Science, EarlyView.Pischiutta F and coworkers identify prostaglandins and kynurenine as key mediators of the mesenchymal stromal cells‐derived secretome's neuroprotective effects. A synthetic cocktail composed of these factors promotes long‐term functional recovery, reduces brain structural damage, and modulates neuroinflammation after traumatic brain injury, supporting ...
Francesca Pischiutta +24 more
wiley +1 more source
Potential Metabolomic Linkage in Blood between Parkinson’s Disease and Traumatic Brain Injury
Metabolites, 2018 The etiologic basis for sporadic forms of neurodegenerative diseases has been elusive but likely represents the product of genetic predisposition and various environmental factors. Specific gene-environment interactions have become more salient owing, in
Massimo S. Fiandaca +10 more
doaj +1 more source
Advanced Science, EarlyView.Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang +13 more
wiley +1 more source
Tangles, toxicity, and tau secretion in AD – new approaches to a vexing problem
Frontiers in Neurology, 2013 When the microtubule-associated protein tau is not bound to axonal microtubules (MTs), it becomes hyperphosphorylated and vulnerable to proteolytic cleavage and other changes typically seen in the hallmark tau deposits (neurofibrillary tangles) of tau ...
Kerry eGendreau, Garth F Hall
doaj +1 more source
Notulae Scientia Biologicae, 2023 The study was performed to investigate the possible neuroprotective role of palmatine, a protoberberine alkaloid against aluminum-induced aberration in neurotransmitter levels, excitotoxicity, neuronal inflammation, damage, and degeneration.
Ratna BABURAJ +2 more
doaj +1 more source
Transport of BMAA into Neurons and Astrocytes by System x\u3csub\u3ec\u3c/sub\u3e- [PDF]
, 2018 The study of the mechanism of β-N-methylamino-l-alanine (BMAA) neurotoxicity originally focused on its effects at the N-methyl-d-aspartate (NMDA) receptor. In recent years, it has become clear that its mechanism of action is more complicated.
Albano, Rebecca, Lobner, Doug
core +1 more source
The role of D-serine and glycine as co-agonists of NMDA receptors in motor neuron degeneration and amyotrophic lateral sclerosis (ALS). [PDF]
, 2014 The fundamental role of D-serine as a co-agonist at the N-methyl-D-aspartate receptor (NMDAR), mediating both physiological actions of glutamate in long term potentiation and nociception and also pathological effects mediated by excitotoxicty, are well ...
de Belleroche, J, Paul, P
core +2 more sources
Animal Models and Experimental Medicine, EarlyView.Study workflow. Neuroretinal changes were observed in alloxan‐induced diabetic rabbits, while the retinal vasculature remained unaffected, indicating the successful establishment of a diabetic neuroretinal model. Abstract Background Diabetic retinal neuropathy (DRN) leads to significant visual impairment; however, no existing animal model fully ...
Xinlu Li +9 more
wiley +1 more source
Huntington's disease: An immune perspective [PDF]
, 2011 Copyright © 2011 Annapurna Nayaketal. This article has been made available through the Brunel Open Access Publishing Fund.Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide ...
Ansar, R +4 more
core +3 more sources
Hyperactive Somatostatin Interneurons Contribute to Excitotoxicity in Neurodegenerative Disorders
Nature Neuroscience, 2016 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative disorders whose pathogenesis remains largely unknown.
Wen Zhang +7 more
semanticscholar +1 more source