Results 81 to 90 of about 82,251 (326)

AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury. [PDF]

, 2015
Clinical spinal cord injury (SCI) is accompanied by comorbid peripheral injury in 47% of patients. Human and animal modeling data have shown that painful peripheral injuries undermine long-term recovery of locomotion through unknown mechanisms ...
Beattie, Michael S, Bresnahan, Jacqueline C, Ferguson, Adam R, Grau, James W, Huie, J Russell, Irvine, Karen-Amanda, Lee, Kuan H, Stuck, Ellen D   +7 more
core   +1 more source

Anatomical Associations Between Focal Mitochondrial Metabolism and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a very specific neuroimaging signature, but the molecular underpinnings of the strikingly selective anatomic involvement have not elucidated to date. Accordingly, a large neuroimaging study was conducted with 258 participants to evaluate associations between patterns of neurodegeneration and focal ...
Marlene Tahedl, We Fong Siah, Efstratios Karavasilis, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Foteini Christidi, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Pathologically Activated Neuroprotection via Uncompetitive Blockade of \u3cem\u3eN\u3c/em\u3e-Methyl-d-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin [PDF]

, 2010
Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists with fast off-rate (UFO) may represent promising drug candidates for various neurodegenerative disorders.
Fu, Hongjun, Han, Yifan, Huang, Pingbo, Li, Chaoying, Li, Fushun, Li, Wenming, Luo, Jialie, Ma, Dik-Lung, Pang, Yuanping, Peoples, Robert W., Tang, Jing, Wang, Qinwen, Xia, Jun, Zhao, Yuming   +13 more
core   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury. [PDF]

, 2019
AimThe activation of the TNFR2 receptor is beneficial in several pathologies of the central nervous system, and this study examines whether it can ameliorate the recovery process following spinal cord injury.MethodsEHD2-sc-mTNFR2 , an agonist specific ...
Bethea, John R, Blumenthal, Gary H, Bracchi-Ricard, Valerie, Fischer, Roman, Gerald, Marcus J, Kontermann, Roland E, Moxon, Karen A, Nandakumar, Bharadwaj, Pfizenmaier, Klaus, Ricard, Jerome, Williams, Raushaun   +10 more
core   +2 more sources

Silk fibroin‐based biomaterials for spinal cord injury repair: Recent advances and future prospects

BMEMat, EarlyView.
A comprehensive review on the design principles and current strategies of silk fibroin‐based biomaterials in spinal cord injury repair, focusing on environmentally friendly processing techniques, and the strategies for designing composite scaffolds as well as discussing the advantages and current challenges of silk fibroin‐based biomaterials in spinal ...
Xiaoliang Cui, Xuanwen Wang, Siying Liu, Lilei Wang, Menghong Li, Jun Zhang, Li Wang, Ke‐Qin Zhang   +7 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Clinical-pathological study on β-APP, IL-1β, GFAP, NFL, Spectrin II, 8OHdG, TUNEL, miR-21, miR-16, miR-92 expressions to verify DAI-diagnosis, grade and prognosis [PDF]

, 2018
Traumatic brain injury (TBI) is one of the most important death and disability cause, involving substantial costs, also in economic terms, when considering the young age of the involved subject. Aim of this paper is to report a series of patients treated
A Frati, AA Hyder, AM Palmer, AW Selassie, B Buller, B Roozenbeek, CJ Murray, D Thurman, DH Smith, DK Menon, DM Stein, DR Li, EM Graham, F Masson, F Tagliaferri, FE Sherriff, FM Barabas, FM Shahim, G Illerhaus, H Bayir, HA Kontos, I Humphreys, JB Redell, JB Redell, JB Redell, JF Geddes, JH Adams, JT Povlishock, JT Povlishock, K Blennow, K Dams-O’Connor, K Fukuda, K Sakai, KM O’Connell, L Tao, M Oehmichen, M Oehmichen, M Ogata, M Valiyaveettil, M Ziu, MA Ansari, MB Grosjean, N Stoicea, OG Bhalala, PR Turner, R Sandhir, RM Chesnut, S Griffiths-Jones, S Griffiths-Jones, S Schiavone, S Thornhill, S Yokobori, SK Kwon, T Frugier, T Strickland, TY Sun, V Pietro Di, VA Tyurin, W Peeters, WL Maxwell, WX Wang, X Ge, X Ge, Y Li, Y Zhang, Z Hu   +65 more
core   +3 more sources

Advances in Pharmacological Insights of Borago officinalis: A Comprehensive Review

Biological Diversity, EarlyView.
ABSTRACT Recent growth in phytotherapy and product‐based drug development has increased interest in this plant because of its broad pharmacological activity. This review aims to examine the pharmacological activities, mechanisms, and potential applications of Borago officinalis, focusing on its primary bioactive constituents and therapeutic ...
Zahra Sufwan, Javed Akhtar Ansari, Farogh Ahsan   +2 more
wiley   +1 more source

MPTP-induced degeneration: interference with glutamatergic toxicity [PDF]

, 1994
Parkinson's disease (PD) is characterised by the progressive degeneration of nigrostriatal dopamine (DA) neurons resulting in the major symptoms of akinesia and rigidity.
Lange, Klaus W., Löschmann, P. A., Turski, L., Wachtel, H.   +3 more
core