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Exocytosis through the lens [PDF]
Frontiers in Endocrinology, 2013 Exocytosis, the process in which material is transported from the cell interior to the extracellular space, proceeds through a complex mechanism. Defects in this process are linked to a number of serious illnesses including diabetes, cancer and a range ...
Alicja eGraczyk, Colin eRickman
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iScience, 2023 Summary: Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting EndoC ...
Alexandros Karagiannopoulos +5 more
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Cold Spring Harbor Perspectives in Biology, 2017 Polarized exocytosis is generally considered as the multistep vesicular trafficking process in which membrane-bounded carriers are transported from the Golgi or endosomal compartments to specific sites of the plasma membrane. Polarized exocytosis in cells is achieved through the coordinated actions of membrane trafficking machinery and cytoskeleton ...
Jingwen, Zeng +3 more
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MARCKS protein is phosphorylated and regulates calcium mobilization during human acrosomal exocytosis. [PDF]
PLoS ONE, 2013 Acrosomal exocytosis is a calcium-regulated exocytosis that can be triggered by PKC activators. The involvement of PKC in acrosomal exocytosis has not been fully elucidated, and it is unknown if MARCKS, the major substrate for PKC, participates in this ...
Marcelo J Rodriguez Peña +4 more
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Frontiers in Molecular Neuroscience, 2021 Streams of action potentials or long depolarizations evoke a massive exocytosis of transmitters and peptides from the surface of dendrites, axons and cell bodies of different neuron types.
Francisco F. De-Miguel +13 more
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Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA
Molecular Metabolism, 2020 Objective: A widely recognized metabolic side effect of glucocorticoid (GC) therapy is steroid-induced diabetes mellitus (DM). However, studies on the molecular basis of GC-induced pancreatic beta cell dysfunction in human beta cells are lacking.
Jonathan L.S. Esguerra +8 more
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eLife, 2016 The hormones insulin and glucagon both play important roles in the development of diabetes.
Lena Eliasson, Anna Wendt
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EBioMedicine, 2016 Statins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-lowering drugs are associated with increased incidence of new on-set diabetes.
Vishal A. Salunkhe +9 more
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Journal of Cell Science, 2011 GLUT4 is an insulin-regulated glucose transporter that is responsible for insulin-regulated glucose uptake into fat and muscle cells. In the absence of insulin, GLUT4 is mainly found in intracellular vesicles referred to as GLUT4 storage vesicles (GSVs).
Jacqueline, Stöckli +2 more
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Journal of Nanobiotechnology, 2021 Background Polyamidoamine (PAMAM) dendrimer applications have extended from tumor cells to multidrug-resistant tumor cells. However, their transportation in multidrug-resistant tumor cells remains unclear.
Jie Zhang +7 more
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