Results 1 to 10 of about 153,788 (344)

Exocytosis through the lens [PDF]

Frontiers in Endocrinology, 2013
Exocytosis, the process in which material is transported from the cell interior to the extracellular space, proceeds through a complex mechanism. Defects in this process are linked to a number of serious illnesses including diabetes, cancer and a range ...
Alicja eGraczyk, Colin eRickman
doaj   +3 more sources

Loss of Fanconi anemia proteins causes a reliance on lysosomal exocytosis. [PDF]

Cell Death Dis
Fu BXH, Xu A, Li H, Johnson DE, Grandis JR, Gilbert LA.   +5 more
europepmc   +3 more sources

Glucocorticoid-mediated induction of ZBTB16 affects insulin secretion in human islets and EndoC-βH1 β-cells

iScience, 2023
Summary: Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting EndoC ...
Alexandros Karagiannopoulos, Efraim Westholm, Jones K. Ofori, Elaine Cowan, Jonathan L.S. Esguerra, Lena Eliasson   +5 more
doaj   +1 more source

Polarized Exocytosis [PDF]

Cold Spring Harbor Perspectives in Biology, 2017
Polarized exocytosis is generally considered as the multistep vesicular trafficking process in which membrane-bounded carriers are transported from the Golgi or endosomal compartments to specific sites of the plasma membrane. Polarized exocytosis in cells is achieved through the coordinated actions of membrane trafficking machinery and cytoskeleton ...
Jingwen, Zeng, Shanshan, Feng, Bin, Wu, Wei, Guo   +3 more
openaire   +2 more sources

MARCKS protein is phosphorylated and regulates calcium mobilization during human acrosomal exocytosis. [PDF]

PLoS ONE, 2013
Acrosomal exocytosis is a calcium-regulated exocytosis that can be triggered by PKC activators. The involvement of PKC in acrosomal exocytosis has not been fully elucidated, and it is unknown if MARCKS, the major substrate for PKC, participates in this ...
Marcelo J Rodriguez Peña, Jimena V Castillo Bennett, Osvaldo M Soler, Luis S Mayorga, Marcela A Michaut   +4 more
doaj   +1 more source

Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA

Molecular Metabolism, 2020
Objective: A widely recognized metabolic side effect of glucocorticoid (GC) therapy is steroid-induced diabetes mellitus (DM). However, studies on the molecular basis of GC-induced pancreatic beta cell dysfunction in human beta cells are lacking.
Jonathan L.S. Esguerra, Jones K. Ofori, Mototsugu Nagao, Yuki Shuto, Alexandros Karagiannopoulos, Joao Fadista, Hitoshi Sugihara, Leif Groop, Lena Eliasson   +8 more
doaj   +1 more source

Extrasynaptic Communication

Frontiers in Molecular Neuroscience, 2021
Streams of action potentials or long depolarizations evoke a massive exocytosis of transmitters and peptides from the surface of dendrites, axons and cell bodies of different neuron types.
Francisco F. De-Miguel, Francisco F. De-Miguel, Carolina Leon-Pinzon, Susana G. Torres-Platas, Vanessa del-Pozo, Guillermo A. Hernández-Mendoza, Dilia Aguirre-Olivas, Bruno Méndez, Sharlen Moore, Celeste Sánchez-Sugía, Marco Antonio García-Aguilera, Alejandro Martínez-Valencia, Guillermo Ramírez-Santiago, J. Miguel Rubí   +13 more
doaj   +1 more source

Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses [PDF]

, 2006
Synaptic vesicle (SV) exocytosis mediating neurotransmitter release occurs spontaneously at low intraterminal calcium concentrations and is stimulated by a rise in intracellular calcium.
A. Scheuber, Blagoveshchenskaya, Dell'Angelica, Fa  ndez, G. Raposo, Goda, Guti  rrez, Hayashi, J.-C. Poncer, Kamiya, Kantheti, L. Danglot, Li, Lopantsev, Musleh, Muzerelle, R. Rudge, Rizzoli, Rosenmund, Sakaba, Schoch, Sj  str  m, Stobrawa, Stoppini, Sudhof, Sugita, Sugita, T. Binz, T. Galli, Takei, Vogt, Woodhall, Xu   +32 more
core   +6 more sources

Partners for life

eLife, 2016
The hormones insulin and glucagon both play important roles in the development of diabetes.
Lena Eliasson, Anna Wendt
doaj   +1 more source

Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]

, 1990
The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Ahnert-Hilger, G., Dayanithi, G., Gratzl, Manfred, Nordmann, J. J., Weller, U.   +4 more
core   +1 more source