Results 11 to 20 of about 167,613 (264)
tPA-GFP is a reliable probe for detecting compound exocytosis in human pancreatic β-cells. [PDF]
FASEB BioadvPancreatic β‐cells secrete insulin stored in large dense core vesicles (LDCV) by fusion of vesicle and plasma membrane during a process called insulin exocytosis.
Makam AA +5 more
europepmc +2 more sources
SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor. [PDF]
PLoS ONE, 2015 Endothelial exocytosis regulates vascular thrombosis and inflammation. The trafficking and release of endothelial vesicles is mediated by SNARE (Soluble NSF Attachment protein REceptors) molecules, but the exact identity of endothelial SNAREs has been ...
Qiuyu Martin Zhu +2 more
doaj +2 more sources
Rab10 regulates neuropeptide release by maintaining Ca<sup>2+</sup> homeostasis and protein synthesis. [PDF]
ElifeDense core vesicles (DCVs) transport and release various neuropeptides and neurotrophins that control diverse brain functions, but the DCV secretory pathway remains poorly understood.
Dong J +6 more
europepmc +2 more sources
Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction. [PDF]
ElifeNeuropeptides and neurotrophins are stored in and released from dense core vesicles (DCVs). While DCVs and synaptic vesicles (SVs) share fundamental SNARE/SM proteins for exocytosis, a detailed understanding of DCV exocytosis remains elusive. We recently
Abramian A +5 more
europepmc +2 more sources
MARCKS protein is phosphorylated and regulates calcium mobilization during human acrosomal exocytosis. [PDF]
PLoS ONE, 2013 Acrosomal exocytosis is a calcium-regulated exocytosis that can be triggered by PKC activators. The involvement of PKC in acrosomal exocytosis has not been fully elucidated, and it is unknown if MARCKS, the major substrate for PKC, participates in this ...
Marcelo J Rodriguez Peña +4 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 Streams of action potentials or long depolarizations evoke a massive exocytosis of transmitters and peptides from the surface of dendrites, axons and cell bodies of different neuron types.
Francisco F. De-Miguel +13 more
doaj +1 more source
Lysosomal Exocytosis: The Extracellular Role of an Intracellular Organelle
Membranes, 2020 Lysosomes are acidic cell compartments containing a large set of hydrolytic enzymes. These lysosomal hydrolases degrade proteins, lipids, polysaccharides, and nucleic acids into their constituents. Materials to be degraded can reach lysosomes either from
B. Tancini +7 more
semanticscholar +1 more source
Insulin granule biogenesis and exocytosis
Cellular and Molecular Life Sciences, 2020 Insulin is produced by pancreatic β-cells, and once released to the blood, the hormone stimulates glucose uptake and suppresses glucose production. Defects in both the availability and action of insulin lead to elevated plasma glucose levels and are ...
Muhmmad Omar-Hmeadi, Olof Idevall-Hagren
semanticscholar +1 more source
Intracellular Electrochemical Nanomeasurements Reveal that Exocytosis of Molecules at Living Neurons is Subquantal and Complex [PDF]
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020,
59 (17), pp.6711-6714, 2020 Since the early work of Bernard Katz, the process of cellular chemical communication via exocytosis, quantal release, has been considered to be all or none. Recent evidence has shown exocytosis to be partial or 'subquantal' at single-cell model systems, but there is a need to understand this at communicating nerve cells.
arxiv +1 more source
eLife, 2016 The hormones insulin and glucagon both play important roles in the development of diabetes.
Lena Eliasson, Anna Wendt
doaj +1 more source