Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis
OncoTarget, 2017 We have recently shown that hydrophobic weak base anticancer drugs are highly sequestered in acidic lysosomes, inducing TFEB-mediated lysosomal biogenesis and markedly increased lysosome numbers per cell.
B. Zhitomirsky, Y. Assaraf
semanticscholar +1 more source
Modeling membrane curvature generation using mechanics and machine learning [PDF]
, 2022 The deformation of cellular membranes regulates trafficking processes, such as exocytosis and endocytosis. Classically, the Helfrich continuum model is used to characterize the forces and mechanical parameters that cells tune to accomplish membrane shape changes.
arxiv +1 more source
Exocytosis of Weibel–Palade bodies: how to unpack a vascular emergency kit
Journal of Thrombosis and Haemostasis, 2018 The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood loss and prevent or overcome infections in the event of vascular trauma.
M. Schillemans +4 more
semanticscholar +1 more source
Arrangement of Annexin A2 tetramer and its impact on the structure and diffusivity of supported lipid bilayers [PDF]
Soft Matter, 2010, 6, 4084-4094, 2010 Annexins are a family of proteins that bind to anionic phospholipid membranes in a Ca2+-dependent manner. Annexin A2 forms heterotetramers (Anx A2t) with the S100A10 (p11) protein dimer. The tetramer is capable of bridging phospholipid membranes and it has been suggested to play a role in Ca2+-dependent exocytosis and cell-cell adhesion of metastatic ...
arxiv +1 more source
Postsynaptic Synaptotagmins Mediate AMPA Receptor Exocytosis During LTP
Nature, 2017 Strengthening of synaptic connections by NMDA (N-methyl-d-aspartate) receptor-dependent long-term potentiation (LTP) shapes neural circuits and mediates learning and memory.
Dick Wu +8 more
semanticscholar +1 more source
Spatiotemporal organization of exocytosis emerges during neuronal shape change
Journal of Cell Biology, 2018 Neurite elongation and branching in developing neurons requires plasmalemma expansion, hypothesized to occur primarily via exocytosis. We posited that exocytosis in developing neurons and nonneuronal cells would exhibit distinct spatiotemporal ...
Fabio Urbina, S. Gomez, S. Gupton
semanticscholar +1 more source
Reductive chain separation of botulinum A toxin — a prerequisite to its inhibitory action on exocytosis in chromaffin cells [PDF]
, 1989 Cleavage of the disulfide bond linking the heavy and the light chains of tetanus toxin is necessary for its inhibitory action on exocytotic release ofcatecholamines from permeabi1ized chromaffin cells [(1989) FEBS Lett. 242, 245-248; (1989) J. Neurochern.
Ahnert-Hilger +25 more
core +1 more source
The dynamics of somatic exocytosis in monoaminergic neurons
Frontiers in Physiology, 2012 Some monoaminergic neurons can release neurotransmitters by exocytosis from their cell bodies. The amount of monoamine released by somatic exocytosis can be comparable to that released by synaptic exocytosis, though neither the underlying mechanisms nor ...
Bidyut eSarkar +6 more
doaj +1 more source
Vomocytosis: Too Much Booze, Base, or Calcium? [PDF]
, 2019 Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of mechanisms, and typically break down internalized cargo into small macromolecules.
Aaron +98 more
core +2 more sources
Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source