Results 71 to 80 of about 167,613 (264)
Lipids in Health and Disease, 2020 Background The regulation of exocytosis is physiologically vital in cells and requires a variety of distinct proteins and lipids that facilitate efficient, fast, and timely release of secretory vesicle cargo.
Dominique C. Stephens +3 more
doaj +1 more source
Exocytosis, Endocytosis, and Their Coupling in Excitable Cells
Frontiers in Molecular Neuroscience, 2017 Evoked exocytosis in excitable cells is fast and spatially confined and must be followed by coupled endocytosis to enable sustained exocytosis while maintaining the balance of the vesicle pool and the plasma membrane.
Kuo Liang, Lisi Wei, Liangyi Chen
semanticscholar +1 more source
Local accumulation times in a diffusion-trapping model of synaptic receptor dynamics [PDF]
arXiv, 2022 The lateral diffusion and trapping of neurotransmitter receptors within the postsynaptic membrane of a neuron plays a key role in determining synaptic strength and plasticity. Trapping is mediated by the reversible binding of receptors to scaffolding proteins (slots) within a synapse.
arxiv
Regulated lysosomal exocytosis mediates cancer progression
Science Advances, 2015 LAMP1 oversialylation results in excessive lysosomal exocytosis, promoting tumor invasion and drug resistance. Understanding how tumor cells transition to an invasive and drug-resistant phenotype is central to cancer biology, but the mechanisms ...
Eda Machado +12 more
semanticscholar +1 more source
Introduction of Macromolecules into Bovine Adrenal Medullary Chromaffin Cells and Rat Pheochromocytoma Cells (PC12) by Permeabilization with Streptolysin O: Inhibitory Effect of Tetanus Toxin on Catecholamine Secretion [PDF]
, 1989 Conditions are described for controlled plasma membrane permeabilization of rat pheochromocytoma cells (PC12) and cultured bovine adrenal chromaffin cells by Streptolysin O (SLO).
Ahnert-Hilger G. +29 more
core +1 more source
Exocytosis and endocytosis: modes, functions, and coupling mechanisms.
Annual Review of Physiology, 2014 Vesicle exocytosis releases content to mediate many biological events, including synaptic transmission essential for brain functions. Following exocytosis, endocytosis is initiated to retrieve exocytosed vesicles within seconds to minutes.
Ling-Gang Wu +3 more
semanticscholar +1 more source
Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion. [PDF]
, 2012 The actin cortex both facilitates and hinders the exocytosis of secretory granules. How cells consolidate these two opposing roles was not well understood. Here we show that antigen activation of mast cells induces oscillations in Ca(2+) and PtdIns(4,5)P(
Meyer, T, Wollman, R
core +1 more source
Respiratory Research, 2010 Background Perfluorocarbons (PFC) are used to improve gas exchange in diseased lungs. PFC have been shown to affect various cell types. Thus, effects on alveolar type II (ATII) cells and surfactant metabolism can be expected, data, however, are ...
Ravasio Andrea +5 more
doaj +1 more source
Membrane budding driven by intra-cellular ESCRT-III filaments [PDF]
arXiv, 2021 Exocytosis is a common transport mechanism via which cells transport out non-essential macro-molecules (cargo) into the extra cellular space. ESCRT-III proteins are known to help in this. They polymerize into a conical spring like structure and help deform the cell membrane locally into a bud which wrapps the outgoing cargo. we model this process using
arxiv
Minimal requirements for exocytosis [PDF]
, 1985 The membrane-permeabilizing effects of streptolysin O, staphylococcal alpha-toxin, and digitonin on cultured rat pheochromocytoma cells were studied. All three agents perturbed the plasma membrane, causing release of intracellular 86Rb+ and uptake of ...
Ahnert-Hilger, G. +2 more
core