Results 41 to 50 of about 265,040 (167)

The possible impact of persistent virus infection on the function of the RNAi machinery in insects: a hypothesis

Frontiers in Physiology, 2013
RNAi experiments in insects are characterized by great variability in efficiency; for instance beetles and locusts are very amenable to dsRNA-mediated gene silencing, while other insect groups, most notably lepidopterans, are more refractory to RNAi ...
Luc eSwevers, Jozef eVanden Broeck, Guy eSmagghe   +2 more
doaj   +1 more source

The inducible blockage of RNAi reveals a role for polyunsaturated fatty acids in the regulation of dsRNA-endocytic capacity in Bactrocera dorsalis

Scientific Reports, 2017
Exogenous double-stranded RNA (dsRNA) can trigger gene silencing through the RNA interference (RNAi) pathway. Our previous research established that Bactrocera dorsalis can block RNAi after an initial priming of exposure to dsRNA.
Xiaolong Dong, Xiaoxue Li, Qiujia Li, Hongmei Jia, Hongyu Zhang   +4 more
doaj   +1 more source

High-Pressure-Sprayed Double Stranded RNA Does Not Induce RNA Interference of a Reporter Gene

Frontiers in Plant Science, 2020
In plants, RNA interference (RNAi) is an effective defense mechanism against pathogens and pests. RNAi mainly involves the micro RNA and the small interfering RNA (siRNA) pathways.
Veli Vural Uslu, Alexandra Bassler, Gabi Krczal, Michael Wassenegger, Michael Wassenegger   +4 more
doaj   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Exogenous double‐stranded RNA inhibits the infection physiology of rust fungi to reduce symptoms in planta [PDF]

, 2023
Rust fungi (Pucciniales) are a diverse group of plant pathogens in natural and agricultural systems. They pose ongoing threats to the diversity of native flora and cause annual crop yield losses.
Soffe, Rebecca, Gardiner, Donald M., Garrill, Ashley, Rebecca Soffe, Anne Sawyer, Donald M. Gardiner, Nock, Volker, McTaggart, Alistair R., Pame, Leny Jane S., Sarah Sale, Leny Jane S. Pame, Sawyer, Anne, Grant R. Smith, Shuey, Louise S., Louise S. Shuey, Volker Nock, Bernard J. Carroll, Sale, Sarah, Neena Mitter, Degnan, Rebecca M., Rebecca M. Degnan, Carroll, Bernard J., Alistair R. McTaggart, Ashley Garrill, Smith, Grant R., Mitter, Neena   +25 more
core   +2 more sources

Physiological Conditions and dsRNA Application Approaches for Exogenously induced RNA Interference in Arabidopsis thaliana

Plants, 2021
Recent studies have revealed that foliar application of double-stranded RNAs (dsRNAs) or small-interfering RNAs (siRNAs) encoding specific genes of plant pathogens triggered RNA interference (RNAi)-mediated silencing of the gene targets.
Konstantin V. Kiselev, Andrey R. Suprun, Olga A. Aleynova, Zlata V. Ogneva, Alexandra S. Dubrovina   +4 more
doaj   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control

Biotechnology and Bioengineering, EarlyView.
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Exogenous Application of dsRNA in Plant Protection: Efficiency, Safety Concerns and Risk Assessment [PDF]

The use of double-stranded RNA (dsRNA) for plant protection shows great potential as a sustainable alternative to traditional pesticides. This review summarizes the current state of knowledge on using exogenous dsRNA in plant protection and includes the ...
Amari, Khalid, Mohammad Vatanparast, Lisa Merkel, Merkel, Lisa, Khalid Amari, Vatanparast, Mohammad   +5 more
core   +1 more source