Crystallographic Studies of Bacterial Exoribonucleases [PDF]
The Scientific World Journal, 2002 INTRODUCTION. Ribonucleases (RNases) play a central role in all cellular RNA processes. These processes include mRNA degradation, and maturation and turnover of stable RNAs, which are vital for the proper functioning of all cells. E. coli has served as a model system for understanding the role of ribonucleases in RNA metabolism, and eight distinct ...
Tristan J. Fiedler, Arun Malhotra
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RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within [PDF]
Experimental and Molecular MedicineRecent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA processing machinery has revealed previously unknown roles of posttranscriptional regulation in gene expression.
Yoona Seo, Jiho Rhim, Jong Heon Kim
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Regulation of co-translational mRNA decay by PAP and DXO1 in Arabidopsis [PDF]
BMC Plant BiologyBackground mRNA decay is central in the regulation of mRNA homeostasis in the cell. The recent discovery of a co-translational mRNA decay pathway (also called CTRD) has changed our understanding of the mRNA decay process.
Marie-Christine Carpentier +3 more
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Global Characterization of XRN 5′-3′ Exoribonucleases and Their Responses to Environmental Stresses in Plants [PDF]
Diversity, 2021 The XRN family of 5′-3′ Exoribonucleases is functionally conserved in eukaryotic organisms. However, the molecular evolution of XRN proteins in plants and their functions in plant response to environment stresses remain largely unexplored. In this study,
Weimeng Song +5 more
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Exoribonucleases as modulators of virulence in pathogenic bacteria [PDF]
Frontiers in Cellular and Infection Microbiology, 2012 Pathogenic bacteria are responsible for severe diseases worldwide. RNA stability is a major player controlling the expression of virulence factors. Ribonucleases (RNases) are the enzymes responsible for the maturation and degradation of RNA molecules (Arraiano et al., 2010; Silva et al., 2011).
Rute G. Matos +4 more
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How hydrolytic exoribonucleases impact human disease: Two sides of the same story [PDF]
FEBS Open Bio, 2023 RNAs are extremely important molecules inside the cell, which perform many different functions. For example, messenger RNAs, transfer RNAs and ribosomal RNAs are involved in protein synthesis, whereas noncoding RNAs have numerous regulatory roles ...
Susana M. Costa +4 more
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Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure [PDF]
Nature CommunicationsViruses from the Flaviviridae family contain human relevant pathogens that generate subgenomic noncoding RNAs during infection using structured exoribonuclease resistant RNAs (xrRNAs).
Conner J. Langeberg +4 more
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Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities. [PDF]
Protein SciAbstract Human RNA capping is critical for mRNA splicing, protection of RNA from 5′ exonucleases in the cytoplasm, and targeting to the ribosome. Human RNMT, CMTR1, and CMTR2 are RNA methyltransferases involved in the RNA capping process. They play a significant role in the proliferation and differentiation of embryonic stem cells and have been ...
Taherian F +7 more
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Conserved domains and structural motifs that differentiate closely related Rex1 and Rex3 DEDDh exoribonucleases are required for their function in yeast [PDF]
PLoS ONEPeter W. Daniels +3 more
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Structural characterization of NrnC identifies unifying features of dinucleases
eLife, 2021 RNA degradation is fundamental for cellular homeostasis. The process is carried out by various classes of endolytic and exolytic enzymes that together degrade an RNA polymer to mono-ribonucleotides.
Justin D Lormand +8 more
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