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RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within [PDF]
Experimental and Molecular MedicineRecent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA processing machinery has revealed previously unknown roles of posttranscriptional regulation in gene expression.
Yoona Seo, Jiho Rhim, Jong Heon Kim
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Crystallographic Studies of Bacterial Exoribonucleases [PDF]
The Scientific World Journal, 2002 INTRODUCTION. Ribonucleases (RNases) play a central role in all cellular RNA processes. These processes include mRNA degradation, and maturation and turnover of stable RNAs, which are vital for the proper functioning of all cells. E. coli has served as a model system for understanding the role of ribonucleases in RNA metabolism, and eight distinct ...
Tristan J. Fiedler, Arun Malhotra
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Exoribonucleases as modulators of virulence in pathogenic bacteria [PDF]
Frontiers in Cellular and Infection Microbiology, 2012 Pathogenic bacteria are responsible for severe diseases worldwide. RNA stability is a major player controlling the expression of virulence factors. Ribonucleases (RNases) are the enzymes responsible for the maturation and degradation of RNA molecules (Arraiano et al., 2010; Silva et al., 2011).
Rute G. Matos +4 more
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Degradation of microRNAs by a Family of Exoribonucleases in Arabidopsis [PDF]
Science, 2008 microRNAs (miRNAs) play crucial roles in numerous developmental and metabolic processes in plants and animals. The steady-state levels of miRNAs need to be properly controlled to ensure normal development. Whereas the framework of miRNA biogenesis is established, factors involved in miRNA degradation remain unknown.
Vanitharani Ramachandran, Xuemei Chen
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Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure [PDF]
Nature CommunicationsViruses from the Flaviviridae family contain human relevant pathogens that generate subgenomic noncoding RNAs during infection using structured exoribonuclease resistant RNAs (xrRNAs).
Conner J. Langeberg +4 more
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Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis. [PDF]
FEBS LettThe S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Gilet L +4 more
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Regulation of co-translational mRNA decay by PAP and DXO1 in Arabidopsis [PDF]
BMC Plant BiologyBackground mRNA decay is central in the regulation of mRNA homeostasis in the cell. The recent discovery of a co-translational mRNA decay pathway (also called CTRD) has changed our understanding of the mRNA decay process.
Marie-Christine Carpentier +3 more
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How hydrolytic exoribonucleases impact human disease: Two sides of the same story [PDF]
FEBS Open Bio, 2023 RNAs are extremely important molecules inside the cell, which perform many different functions. For example, messenger RNAs, transfer RNAs and ribosomal RNAs are involved in protein synthesis, whereas noncoding RNAs have numerous regulatory roles ...
Susana M. Costa +4 more
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Substrate Recognition and Catalysis by the Exoribonuclease RNase R [PDF]
Journal of Biological Chemistry, 2006 RNase R is a processive, 3' to 5' hydrolytic exoribonuclease that together with polynucleotide phosphorylase plays an important role in the degradation of structured RNAs. However, RNase R differs from other exoribonucleases in that it can by itself degrade RNAs with extensive secondary structure provided that a single-stranded 3' overhang is present ...
Helen A. Vincent, Murray P. Deutscher
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Nuclease Activity of the Junín Virus Nucleoprotein C-Terminal Domain [PDF]
Viruses, 2023 The mammarenavirus Junín (JUNV) is the causative agent of Argentine hemorrhagic fever, a severe disease of public health concern. The most abundant viral protein is the nucleoprotein (NP), a multifunctional, two-domain protein with the primary role as ...
Alicia Armella Sierra +6 more
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