Maturation of 23S ribosomal RNA requires the exoribonuclease RNase T [PDF]
RNA, 1999 Ribosomal RNAs are generally synthesized as long, primary transcripts that must be extensively processed to generate the mature, functional species. In Escherichia coli, it is known that the initial 30S precursor is cleaved during its synthesis by the endonuclease RNase III to generate precursors to the 16S, 23S, and 5S rRNAs.
Zhongwei Li +2 more
openaire +3 more sources
Degradation of RNA in bacteria: comparison of mRNA and stable RNA [PDF]
, 2006 Degradation of RNA plays a central role in RNA metabolism. In recent years, our knowledge of the mechanisms of RNA degradation has increased considerably with discovery of the participating RNases and analysis of mutants affected in the various ...
Deutscher, Murray P.
core +2 more sources
PPR Protein BFA2 Is Essential for the Accumulation of the atpH/F Transcript in Chloroplasts
Frontiers in Plant Science, 2019 As a fascinating and complicated nanomotor, chloroplast ATP synthase comprises nine subunits encoded by both the nuclear and plastid genomes. Because of its uneven subunit stoichiometry, biogenesis of ATP synthase and expression of plastid-encoded ATP ...
Lin Zhang +6 more
doaj +1 more source
Prime Editing: A Revolutionary Technology for Precise Treatment of Genetic Disorders
Cell Proliferation, Volume 58, Issue 4, April 2025.This review outlines the latest research advancements in prime editing technology, delivery strategies, and the challenges that must be addressed to fully realize its therapeutic potential, emphasizing the high potential of prime editing in the remission or cure of genetic diseases. ABSTRACT Genetic diseases have long posed significant challenges, with
Mengyao Li, Yi Lin, Qiang Cheng, Tuo Wei
wiley +1 more source
The Exosome Subunit Rrp44 Plays a Direct Role in RNA Substrate Recognition [PDF]
, 2007 The exosome plays key roles in RNA maturation and surveillance, but it is unclear how target RNAs are identified. We report the functional characterization of the yeast exosome component Rrp44, a member of the RNase II family.
Anderson, James T. +2 more
core +2 more sources
Rex1p Deficiency Leads to Accumulation of Precursor Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e and Polyadenylation of Substrate RNAs in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e [PDF]
, 2009 A synthetic genetic array was used to identify lethal and slow-growth phenotypes produced when a mutation in TRM6, which encodes a tRNA modification enzyme subunit, was combined with the deletion of any non-essential gene in Saccharomyces cerevisiae.
Anderson, James T. +5 more
core +1 more source
Regulatory Mechanisms of Exoribonuclease PNPase and Regulatory Small RNA on T3SS of Dickeya dadantii
Molecular Plant-Microbe Interactions, 2010 The type III secretion system (T3SS) is an essential virulence factor for many bacterial pathogens. Polynucleotide phosphorylase (PNPase) is one of the major exoribonucleases in bacteria and plays important roles in mRNA degradation, tRNA processing, and
Quan Zeng +3 more
doaj +1 more source
Plant Biology, Volume 27, Issue 3, Page 347-361, April 2025.Resistance against Tan spot (caused by Pyrenophora tritici‐repentis) in wheat can involve cell wall defences or an absence of susceptibility factors. Abstract Tan Spot disease is caused by the necrotrophic pathogen Pyrenophora tritici‐repentis (Ptr) and poses a significant threat to global wheat production.
L. C. Ferreira +4 more
wiley +1 more source
Impact of alternative carbon sources and antifungal treatment on Candida glabrata biofilms transcription profile [PDF]
, 2016 Candida glabrata is considered a major opportunistic fungal pathogen of humans and has emerged as a leading cause of nosocomial fungal infections. The capacity of this yeast species to cause infections is dependent on the ability to grow within the human
Alves, Rosana +8 more
core +1 more source
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi +9 more
wiley +1 more source