Results 11 to 20 of about 3,047 (148)

Regulation of miRNA content. Part 2. Degradation of miRNAs

Zdorovʹe Rebenka, 2021
The scientific review presents the process of regulation of microRNA content — microRNA degradation. To write the article, information was searched using databases Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The ...
A.E. Abaturov, V.L. Babуch
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Cap-Independent Circular mRNA Translation Efficiency

Vaccines, 2023
Recently, the mRNA platform has become the method of choice in vaccine development to find new ways to fight infectious diseases. However, this approach has shortcomings, namely that mRNA vaccines require special storage conditions, which makes them less
Andrei A. Deviatkin, Ruslan A. Simonov, Kseniya A. Trutneva, Anna A. Maznina, Anastasiia B. Soroka, Anna A. Kogan, Sofya G. Feoktistova, Elena M. Khavina, Olga N. Mityaeva, Pavel Y. Volchkov   +9 more
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Real-time fluorescence detection of exoribonucleases [PDF]

RNA, 2009
The identification of RNases or RNase effectors is a continuous challenge, particularly given the current importance of RNAs in the control of genome expression. Here, we show that a fluorogenic RNA–DNA hybrid is a powerful tool for a real-time fluorescence detection and assay of exoribonucleases (RT-FeDEx).
Sinturel, F., Pellegrini, O., Xiang, S., Tong, L., Condon, C., Bénard, L.   +5 more
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An RNA-seq based comparative approach reveals the transcriptome-wide interplay between 3′-to-5′ exoRNases and RNase Y

Nature Communications, 2020
Bacterial RNA degradation is typically initiated by endoribonucleases and followed by exoribonucleases. Here the authors report the targetome of endoRNase Y in Streptococcus pyogenes, revealing the interplay between RNase Y and 3′-to-5′ exoribonuclease ...
Laura Broglia, Anne-Laure Lécrivain, Thibaud T. Renault, Karin Hahnke, Rina Ahmed-Begrich, Anaïs Le Rhun, Emmanuelle Charpentier   +6 more
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Analysis of mRNA Decay Intermediates in Bacillus subtilis 3′ Exoribonuclease and RNA Helicase Mutant Strains

mBio, 2022
The Bacillus subtilis genome encodes four 3′ exoribonucleases: polynucleotide phosphorylase (PNPase), RNase R, RNase PH, and YhaM. Previous work showed that PNPase, encoded by the pnpA gene, is the major 3′ exonuclease involved in mRNA turnover; in a ...
Shivani Chhabra, Zachary F. Mandell, Bo Liu, Paul Babitzke, David H. Bechhofer   +4 more
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Landscape of functional interactions of human processive ribonucleases revealed by high-throughput siRNA screenings

iScience, 2021
Summary: Processive exoribonucleases are executors of RNA decay. In humans, their physical but not functional interactions were thoughtfully investigated. Here we have screened cells deficient in DIS3, XRN2, EXOSC10, DIS3L, and DIS3L2 with a custom siRNA
Anna Hojka-Osinska, Aleksander Chlebowski, Joanna Grochowska, Ewelina P. Owczarek, Kamila Affek, Kamila Kłosowska-Kosicka, Roman J. Szczesny, Andrzej Dziembowski   +7 more
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Shared properties and singularities of exoribonuclease-resistant RNAs in viruses

Computational and Structural Biotechnology Journal, 2021
What viral RNA genomes lack in size, they make up for in intricacy. Elaborate RNA structures embedded in viral genomes can hijack essential cellular mechanisms aiding virus propagation.
Quentin Vicens, Jeffrey S. Kieft
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Immunosuppressive arenaviral exoribonuclease

Oncotarget, 2015
Arenaviruses cause up to 500,000 zoonotic infections per year in endemic areas of Africa and South America and can lead to severe and lethal hemorrhagic fever (HF) symptoms [1]. Currently, there is no specific antiviral drug or vaccine available for the treatment of these infections, with the exception of the Candid #1 vaccine that has successfully ...
Bjoern, Meyer, Hinh, Ly
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Depletion of trypanosome CTR9 leads to gene expression defects. [PDF]

PLoS ONE, 2012
The Paf complex of Opisthokonts and plants contains at least five subunits: Paf1, Cdc73, Rtf1, Ctr9, and Leo1. Mutations in, or loss of Paf complex subunits have been shown to cause defects in histone modification, mRNA polyadenylation, and transcription
Benard A Ouna, Benson Nyambega, Theresa Manful, Claudia Helbig, Matilda Males, Abeer Fadda, Christine Clayton   +6 more
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Burning the Candle at Both Ends: Have Exoribonucleases Driven Divergence of Regulatory RNA Mechanisms in Bacteria?

mBio, 2021
Regulatory RNAs have emerged as ubiquitous gene regulators in all bacterial species studied to date. The combination of sequence-specific RNA interactions and malleable RNA structure has allowed regulatory RNA to adopt different mechanisms of gene ...
Daniel G. Mediati, David Lalaouna, Jai J. Tree   +2 more
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