Results 11 to 20 of about 6,830 (257)
The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma [PDF]
Arthritis Research & Therapy, 2000 The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75.
Rick Brouwer +2 more
core +11 more sources
The roles of the exoribonucleases DIS3L2 and XRN1 in human disease [PDF]
Biochemical Society Transactions, 2016 RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases that are critical for the degradation of cytoplasmic RNAs. Although the molecular mechanisms of RNA degradation by DIS3L2 and XRN1 have been well studied, less is ...
Amy L. Pashler +3 more
core +7 more sources
Localization of components of the RNA-degrading machine in Bacillus subtilis [PDF]
Frontiers in Microbiology, 2016 In bacteria, the control of mRNA stability is crucial to allow rapid adaptation to changing conditions. In most bacteria, RNA degradation is catalyzed by the RNA degradosome, a protein complex composed of endo- and exoribonucleases, RNA helicases and ...
Nora Cascante-Estepa +2 more
doaj +3 more sources
mBio, 2021 Regulatory RNAs have emerged as ubiquitous gene regulators in all bacterial species studied to date. The combination of sequence-specific RNA interactions and malleable RNA structure has allowed regulatory RNA to adopt different mechanisms of gene ...
Daniel G. Mediati +2 more
doaj +2 more sources
Conserved domains and structural motifs that differentiate closely related Rex1 and Rex3 DEDDh exoribonucleases are required for their function in yeast [PDF]
PLoS ONEPeter W. Daniels +3 more
doaj +3 more sources
Real-time fluorescence detection of exoribonucleases [PDF]
RNA, 2009 The identification of RNases or RNase effectors is a continuous challenge, particularly given the current importance of RNAs in the control of genome expression. Here, we show that a fluorogenic RNA–DNA hybrid is a powerful tool for a real-time fluorescence detection and assay of exoribonucleases (RT-FeDEx).
Sinturel, F. +5 more
openaire +5 more sources
Germline PARN Variants in Telomere Biology Disorders and Challenges in Variant Curation. [PDF]
Mol Genet Genomic MedOnly 44% germline variants in poly(A)‐specific ribonuclease (PARN) reported to cause telomere biology disorders (TBDs) meet pathogenic or likely pathogenic (P/LP) classification criteria. Rare PARN variants are frequent across the gene in unaffected individuals.
Nurelegne HT +6 more
europepmc +2 more sources
Exoribonuclease superfamilies: structural analysis and phylogenetic distribution
Nucleic Acids Research, 2001 Exoribonucleases play an important role in all aspects of RNA metabolism. Biochemical and genetic analyses in recent years have identified many new RNases and it is now clear that a single cell can contain multiple enzymes of this class. Here, we analyze the structure and phylogenetic distribution of the known exoribonucleases.
Y. Zuo
openalex +5 more sources
The nucleolar protein NOL12 is required for processing of large ribosomal subunit rRNA precursors in Arabidopsis [PDF]
BMC Plant Biology, 2023 Background NOL12 5′-3′ exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The most well-described yeast counterpart, Rrp17, is required for maturation of 5.8 and 25S rRNAs, whereas ...
Monika Zakrzewska-Placzek +5 more
doaj +2 more sources
eLife, 2017 RNA-induced silencing complex (RISC) is composed of miRNAs and AGO proteins. AGOs use miRNAs as guides to slice target mRNAs to produce truncated 5' and 3' RNA fragments. The 5' cleaved RNA fragments are marked with uridylation for degradation.
Zhonghui Zhang +9 more
doaj +2 more sources