Results 21 to 30 of about 3,039 (115)
The coronavirus proofreading exoribonuclease mediates extensive viral recombination
PLOS Pathogens, 2020 Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal CoV replication, the mechanisms and determinants of CoV recombination are not known.
Jennifer Gribble +8 more
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Exoribonuclease superfamilies: structural analysis and phylogenetic distribution
Nucleic Acids Research, 2001 Exoribonucleases play an important role in all aspects of RNA metabolism. Biochemical and genetic analyses in recent years have identified many new RNases and it is now clear that a single cell can contain multiple enzymes of this class. Here, we analyze the structure and phylogenetic distribution of the known exoribonucleases.
Y, Zuo, M P, Deutscher
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Suppression of Viral RNA Recombination by a Host Exoribonuclease [PDF]
Journal of Virology, 2006 ABSTRACT RNA viruses of humans, animals, and plants evolve rapidly due to mutations and RNA recombination. A previous genome-wide screen in Saccharomyces cerevisiae , a model host, identified five host genes, including XRN1 , encoding a 5′-3′ exoribonuclease, whose absence led to an
Chi-Ping, Cheng +2 more
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Selective 2′-Hydroxyl Acylation Analyzed by Protection from Exoribonuclease [PDF]
Journal of the American Chemical Society, 2010 Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) is a powerful approach for characterizing RNA structure and dynamics at single-nucleotide resolution. However, SHAPE technology is limited, sometimes severely, because primer extension detection obscures structural information for ~15 nts at the 5′ end and 40–60 nts at the 3′ end of ...
Kady-Ann, Steen +2 more
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A DIStinctively novel exoribonuclease that really likes U
The EMBO Journal, 2013 Regulated degradation plays a major role in determining the levels of both non-coding (miRNA) and coding (mRNA) transcripts. Thus, insights into the factors and pathways that influence this process have broad, interdisciplinary implications. New findings by Malecki et al (2013), Lubas et al (2013), and Chang et al (2013) identify the protein Dis3L2 as ...
Imed E, Gallouzi, Jeffrey, Wilusz
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Human FASTK preferentially binds single‐stranded and G‐rich RNA
The FEBS Journal, Volume 293, Issue 3, Page 729-748, February 2026.Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak +7 more
wiley +1 more source
New Phytologist, Volume 249, Issue 3, Page 1219-1233, February 2026.Summary Chloroplast‐to‐nucleus retrograde signalling enables rapid stress responses in plants, but whether these signals accumulate to affect crop performance across entire growing seasons under field conditions remains unknown. We generated wheat mutants with targeted deletions in specific SAL gene copies from two distinct homeologous groups (TaSAL1 ...
Andrew F. Bowerman +13 more
wiley +1 more source
ISG20L2, a Novel Vertebrate Nucleolar Exoribonuclease Involved in Ribosome Biogenesis [PDF]
Molecular & Cellular Proteomics, 2008 Proteomics analyses of human nucleoli provided molecular bases for an understanding of the multiple functions fulfilled by these nuclear domains. However, the biological roles of about 100 of the identified proteins are unpredictable. The present study describes the functional characterization of one of these proteins, ISG20L2.
Couté, Yohann +7 more
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Advanced Science, Volume 13, Issue 3, 14 January 2026.ToCV‐encoded p22 targets chloroplast plastoglobules (PGs) via directly binding PG structural protein FBN1.1, reducing the size of PG and inhibiting α‐tocopherol biosynthesis via competing with tocopherol cyclase (VTE1). Consequently, the elevated chloroplast ROS not only creates a suitable cellular environment for efficient ToCV infection but also ...
Sijia Liu +8 more
wiley +1 more source
Substrate Recognition and Catalysis by the Exoribonuclease RNase R [PDF]
Journal of Biological Chemistry, 2006 RNase R is a processive, 3' to 5' hydrolytic exoribonuclease that together with polynucleotide phosphorylase plays an important role in the degradation of structured RNAs. However, RNase R differs from other exoribonucleases in that it can by itself degrade RNAs with extensive secondary structure provided that a single-stranded 3' overhang is present ...
Helen A, Vincent, Murray P, Deutscher
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