Results 51 to 60 of about 186,133 (340)

Exosome-drug conjugates delivery: a promising strategy for ameliorating the pharmacokinetic profile of artesunate

Frontiers in Bioengineering and Biotechnology
Artesunate (ATS) is considered the most widely employed artemisnin derivative in the treatment of Plasmodium falciparum malaria. However, poor solubility and low bioavailability of ATS limit its further clinical application.
Da Wang, Yunfei Bai, Guogang Cheng, Shengqiang Shen, Gengwu Xiao, Demei Ma, Ganggang Zhao, Wei Chen, Wei Chen, Tianshi Li, Litao Zhang, Xiaohu Ge, Xiaohu Ge   +12 more
doaj   +1 more source

Exosomes in lung cancer metastasis, diagnosis, and immunologically relevant advances

Frontiers in Immunology, 2023
Lung cancer is a chronic wasting disease with insidious onset and long treatment cycle. Exosomes are specialized extracellular vesicles, at first exosomes were considered as a transporter of cellular metabolic wastes, but recently many studies have ...
Jianhua Zhao, Xiwen Li, Lele Liu, Zhen Zhu, Chunyan He   +4 more
doaj   +1 more source

A Label-Free Platform for Identification of Exosomes from Different Sources. [PDF]

, 2019
Exosomes contain cell- and cell-state-specific cargos of proteins, lipids, and nucleic acids and play significant roles in cell signaling and cell-cell communication.
Bitan, Gal, Dutta, Suman, Ji, Feng, Liu, Zirui, Mesgarzadeh, Neda, Xie, Ya-Hong, Yan, Zhongbo, Yu, Xinke   +7 more
core   +2 more sources

Role of Exosomes and Exosomal microRNAs in Cancer

Future Science OA, 2020
A growing body of evidence indicates that exosomes play a critical role in the cell-cell communication process. Exosomes are biological nanoparticles with an average diameter of 30-100 nm in size and are produced by almost all cell types in the human body; however, cancer cells contain higher concentrations of exosomes than healthy cells.
openaire   +4 more sources

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer [PDF]

, 2018
Therapeutic approaches aimed at curing prostate cancer are only partially successful given the occurrence of highly metastatic resistant phenotypes that frequently develop in response to therapies.
Altieri, Dario C., Bowler, Nicholas, Craig Hooper, D., Dutta, Anindita, Ertel, Adam, Fedele, Carmine, Forsberg, Flemming, Fortina, Paolo, Gabrilovich, Dmitry I., Harshyne, Larry A., Kean, Rhonda B., Kelly, William K., Kossenkov, Andrew V., Krishn, Shiv Ram, Kurtoglu, Senem, Languino, Lucia R., Liu, Qin, Lu, Huimin, Speicher, David W., Stanczak, Maria, Tang, Hsin-Yao, Wang, Kerith, Weinreb, Paul H., Yu, Lei   +23 more
core   +1 more source

Exosomes and exosomal miRNAs in cardiovascular protection and repair [PDF]

Vascular Pharmacology, 2015
Cell-cell communication between cardiac and vascular cells and from stem and progenitor cells to differentiated cardiovascular cells is both an important and complex process, achieved through a diversity of mechanisms that have an impact on cardiovascular biology, disease and therapeutics.
Emanueli, Costanza, Shearn, Andrew I U, Angelini, Gianni D, Sahoo, Susmita   +3 more
openaire   +4 more sources

Development of an Organ-Directed Exosome-Based siRNA-Carrier Derived from Autologous Serum for Lung Metastases and Testing in the B16/BL6 Spontaneous Lung Metastasis Model

Pharmaceutics, 2022
Exosomes are nano-sized extracellular vesicles that are known to carry various messages to distant cells. It was recently reported that cancer-derived exosomes are orientated to metastatic organs. However, there are no reports on drug carrier development
Mai Hazekawa, Takuya Nishinakagawa, Masato Hosokawa, Daisuke Ishibashi   +3 more
doaj   +1 more source

Microvesicles and exosomes: new players in metabolic and cardiovascular disease [PDF]

, 2016
The past decade has witnessed an exponential increase in the number of publications referring to extracellular vesicles (EVs). For many years considered to be extracellular debris, EVs are now seen as novel mediators of endocrine signalling via cell-to ...
Charlotte Lawson, Daniel, Derek M Yellon, Gunduz, Headland, Joop, Jorgensen, Jose M Vicencio, Larson, Lobb, Macey, Mesri, Nomura, Pospichalova, Raturi, Scholz, Sean M Davidson, Ueba, Villarroya-Beltri, Vrijsen, Wang, Welton   +21 more
core   +2 more sources

Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

Genomics, Proteomics & Bioinformatics, 2015
Abstract Exosomes are 40–100 nm nano-sized vesicles that are released from many cell types into the extracellular space. Such vesicles are widely distributed in various body fluids. Recently, mRNAs and microRNAs (miRNAs) have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate ...
Zhang, Jian, Li, Sha, Li, Lu, Li, Meng, Guo, Chongye, Yao, Jun, Mi, Shuangli   +6 more
openaire   +3 more sources

Assessment of bovine milk exosome preparation and lyophilized powder stability

Journal of Extracellular Biology
Exosomes are cell‐derived nanovesicles that play a crucial role in intercellular communication, presenting promising potential as biomarkers and therapeutic agents.
Lu Lu, Chunle Han, Miao Wang, Huanqing Du, Ning Chen, Mengya Gao, Na Wang, Dongli Qi, Wei Bai, Jianxin Yin, Fengwei Dong, Tianshi Li, Xiaohu Ge   +12 more
doaj   +1 more source