Results 51 to 60 of about 222,944 (406)
Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle
Oncogenesis, 2022 Exosomes belong to a subpopulation of extracellular vesicles secreted by the dynamic multistep endocytosis process and carry diverse functional molecular cargoes, including proteins, lipids, nucleic acids (DNA, messenger and noncoding RNA), and ...
Xia Wang, Lu Tian, Jingyi Lu, I. Ng
semanticscholar +1 more source
EMBO reports, 2007 The correct processing, quality control and turnover of cellular RNA molecules is crucial to many aspects of cell physiology. The exosome—a large molecular assembly with exoribonuclease activity—has emerged as a crucial component in many, if not most, stages of RNA metabolism, including degradation and maturation of ribosomal RNA, RNA quality control ...
Karl-Peter Hopfner, Sophia Hartung
openaire +3 more sources
Extracellular vesicles released by steatotic hepatocytes alter adipocyte metabolism
Journal of Extracellular Biology, 2022 The composition of extracellular vesicles (EVs) is altered in many pathological conditions, and their molecular content provides essential information on features of parent cells and mechanisms of crosstalk between cells and organs.
J.E. Mleczko +16 more
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Circular RNA CDR1as Inhibits the Metastasis of Gastric Cancer through Targeting miR-876-5p/GNG7 Axis
Gastroenterology Research and Practice, 2021 Circular RNA CDR1as has been demonstrated to participate in various cancer progressions as miRNA sponges. The exact underlying mechanisms of CDR1as on gastric cancer (GC) metastasis remain unknown. Here, we found that CDR1as knockdown facilitated GC cell
Jiajia Jiang +5 more
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Hepatology Communications, 2018 Drug‐induced liver injury (DILI) is a serious worldwide health problem that accounts for more than 50% of acute liver failure. There is a great interest in clinical diagnosis and pharmaceutical industry to elucidate underlying molecular mechanisms and ...
Laura Palomo +7 more
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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Nature Network Boston, 2012 Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function of melanoma-derived exosomes in the formation of primary tumors and metastases in mice and human subjects.
H. Peinado +24 more
semanticscholar +1 more source
Exosomes: biogenesis, biologic function and clinical potential
Cell & Bioscience, 2019 Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of multivesicular bodies and the plasma membrane. They were shown to carry cell-specific cargos of proteins, lipids, and genetic materials, and can be selectively taken
Y. Zhang +3 more
semanticscholar +1 more source
Emerging Exosomes and Exosomal MiRNAs in Spinal Cord Injury [PDF]
Frontiers in Cell and Developmental Biology, 2021 Acute spinal cord injury (SCI) is a serious traumatic event to the spinal cord with considerable morbidity and mortality. This injury leads to short- and long-term variations in the spinal cord, and can have a serious effect on the patient’s sensory, motor, or autonomic functions.
Zhihan Zhu +5 more
openaire +4 more sources
Assessing the role of surface glycans of extracellular vesicles on cellular uptake
Scientific Reports, 2019 Extracellular vesicles (EVs) are important mediators of cell-cell communication in a broad variety of physiological contexts. However, there is ambiguity around the fundamental mechanisms by which these effects are transduced, particularly in relation to
Charles Williams +8 more
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Artificial exosomes for translational nanomedicine
Journal of Nanobiotechnology, 2021 Exosomes are lipid bilayer membrane vesicles and are emerging as competent nanocarriers for drug delivery. The clinical translation of exosomes faces many challenges such as massive production, standard isolation, drug loading, stability and quality ...
Yong-Jiang Li +7 more
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