Results 71 to 80 of about 186,133 (340)
Broad role for YBX1 in defining the small noncoding RNA composition of exosomes. [PDF]
, 2017 RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA composition of EVs is challenging due to their coisolation with contaminants, lack of knowledge of the mechanisms of RNA sorting into EVs, and limitations of ...
Lambowitz, Alan M +6 more
core +1 more source
Exosomes: Mechanisms of Uptake [PDF]
Journal of Circulating Biomarkers, 2015 Exosomes are 30–100 nm microvesicles which contain complex cellular signals of RNA, protein and lipids. Because of this, exosomes are implicated as having limitless therapeutic potential for the treatment of cancer, pregnancy complications, infections, and autoimmune diseases. To date we know a considerable amount about exosome biogenesis and secretion,
Jonathan M. Morris +6 more
openaire +6 more sources
Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design
FEBS Letters, EarlyView.Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos +3 more
wiley +1 more source
Vietnam Journal of Science, Technology and Engineering, 2022 Exosomes represent an important mode of intercellular communication and play key roles in many physiological and pathological processes. Exosomes have hitherto exhibited their capacity to modulate biological activities through their carrying of ...
Hoang Huong Diem +4 more
doaj +1 more source
Development of Stable Cell Lines for the Production of Hematopoietic Stem Cell Targeted Exosomes [PDF]
, 2018 Exosomes represent a promising new approach to targeted drug delivery. Current research explores the ability of these naturally occurring nanoparticles to transport therapeutic cargo to specific tissues of the body and to subsequently enter the cells of ...
Beard, Anja, Ehlinger, Zach
core +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Stem Cells International, 2019 Mesenchymal stem cells derived from human umbilical cord (hucMSCs) are considered a promising tool for regenerative medicine. circRNAs as newly discovered noncoding RNAs are involved in multiple biological processes.
Lunyu Yang +8 more
doaj +1 more source
Exosomes in developmental signalling [PDF]
Development, 2016 In order to achieve coordinated growth and patterning during development, cells must communicate with one another, sending and receiving signals that regulate their activities. Such developmental signals can be soluble, bound to the extracellular matrix, or tethered to the surface of adjacent cells.
Ian John McGough, Jean-Paul Vincent
openaire +3 more sources
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. [PDF]
PLoS ONE, 2009 BACKGROUND: Metastatic melanoma is an untreatable cancer lacking reliable and non-invasive markers of disease progression. Exosomes are small vesicles secreted by normal as well as tumor cells.
Mariantonia Logozzi +17 more
doaj +1 more source