Role of the Spore Coat Proteins CotA and CotB, and the Spore Surface Protein CDIF630_02480, on the Surface Distribution of Exosporium Proteins in Clostridioides difficile 630 Spores [PDF]
Microorganisms, 2022 Clostridioides difficile is Gram-positive spore-former bacterium and the leading cause of nosocomial antibiotic-associated diarrhea. During disease, C. difficile forms metabolically dormant spores that persist in the host and contribute to recurrence of ...
Nicolás Montes-Bravo +5 more
doaj +3 more sources
Characterization of Exosporium Layer Variability of Clostridioides Difficile Spores in the Epidemically Relevant Strain R20291 [PDF]
Frontiers in Microbiology, 2020 Clostridioides difficile is a Gram-positive anaerobic intestinal pathogenic bacterium and the causative agent of antibiotic-associated diarrhea. C. difficile spore is a dormant state which acts as a vehicle of transmission and infection. In C.
Daniel Paredes-Sabja +2 more
exaly +4 more sources
Clostridium difficile exosporium cysteine-rich proteins are essential for the morphogenesis of the exosporium layer, spore resistance, and affect C. difficile pathogenesis. [PDF]
PLoS Pathogens, 2018 Clostridium difficile is a Gram-positive spore-former bacterium and the leading cause of nosocomial antibiotic-associated diarrhea that can culminate in fatal colitis. During the infection, C.
Paulina Calderón-Romero +8 more
doaj +7 more sources
YwdL in Bacillus cereus: its role in germination and exosporium structure. [PDF]
PLoS ONE, 2011 In members of the Bacillus cereus group the outermost layer of the spore is the exosporium, which interacts with hosts and the environment. Efforts have been made to identify proteins of the exosporium but only a few have so far been characterised and ...
Cassandra Terry +4 more
doaj +5 more sources
Localization of the CotY and ExsY proteins to the exosporium basal layer of Bacillus anthracis [PDF]
MicrobiologyOpen, 2022 Spores are an infectious form of the zoonotic bacterial pathogen, Bacillus anthracis. The outermost spore layer is the exosporium, comprised of a basal layer and an external glycoprotein nap layer.
Jorge Durand‐Heredia +1 more
doaj +4 more sources
The role of the exosporium in the environmental distribution of anthrax [PDF]
Journal of Applied Microbiology, 2012 To determine the contribution of the exosporium, the outer layer of the Bacillus anthracis spore, to soil attachment. Persistence of spores in soil and their ability to infect animals has been linked to a range of factors which include the presence of organic material and calcium (OMC), pH > 6.0, temperatures above 15.5°C and cycles of local flooding ...
G, Williams +3 more
openaire +3 more sources
Assessment of chemical methods in the extraction of spore surface layers in Clostridioides difficile spores [PDF]
mSphereClostridioides difficile spores are essential for initiation, recurrence, and transmission of C. difficile infections (CDI). These outermost layers of the spore, the exosporium and spore coat, are responsible for initial interactions with the host and ...
Javier Sanchez +6 more
doaj +2 more sources
Crystal structure and induced stability of trimeric BxpB: implications for the assembly of BxpB-BclA complexes in the exosporium of Bacillus anthracis [PDF]
mBio, 2023 The outermost exosporium layer of Bacillus anthracis spores, the causative agents of anthrax, is comprised of a basal layer and an external hair-like nap. The nap includes filaments composed of trimers of the collagen-like glycoprotein BclA.
Debasish Chattopadhyay +4 more
doaj +2 more sources
A sporulation signature protease is required for assembly of the spore surface layers, germination and host colonization in Clostridioides difficile. [PDF]
PLoS Pathogens, 2023 A genomic signature for endosporulation includes a gene coding for a protease, YabG, which in the model organism Bacillus subtilis is involved in assembly of the spore coat.
Eleonora Marini +12 more
doaj +2 more sources
A new fluorescence-based approach for direct visualization of coat formation during sporulation in Bacillus cereus [PDF]
Scientific Reports, 2023 The human pathogenic bacteria Bacillus cereus, Bacillus anthracis and the entomopathogenic Bacillus thuringiensis form spores encased in a protein coat surrounded by a balloon-like exosporium.
Armand Lablaine +8 more
doaj +2 more sources