Results 181 to 190 of about 25,445 (232)

Crystallization of exotoxin A from Pseudomonas aeruginosa

Journal of Molecular Biology, 1982
Abstract Exotoxin A from Pseudomonas aeruginosa has been crystallized in a form suitable for high resolution diffraction analysis. The crystals, grown in the presence of high concentrations of polyethylene glycol (20%, w/v) and of NaCl (1.5 m ), are monoclinic and contain one monomeric toxin molecule per asymmetric unit. The space group is P 2 1 ,
R J, Collier, D B, McKay
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Levodopa – an exotoxin or a therapeutic drug?

Journal of Neurology, 2000
Auto-oxidation of levodopa generates toxic metabolites, such as free radicals, semiquinones and quinones. In vitro, levodopa is a powerful toxin that is lethal to cultures of neurones. This raises the concern that levodopa may also be toxic in vivo, and that chronic treatment with levodopa could induce further damage to nigrostriatal neurones in ...
E, Melamed, D, Offen, A, Shirvan, I, Ziv
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Pseudomonas aeruginosaExotoxin A

New England Journal of Medicine, 1980
Pseudomonas aeruginosa is an opportunistic pathogen that causes more than 100,000 infections in the United States each year. Pseudomonas infections are associated with considerable morbidity and mortality despite the use of modern antibiotics.1 Recognition of the limitations of existing therapy for pseudomonas disease has stimulated renewed interest in
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Purification of Streptococcal Pyrogenic Exotoxin A

2003
Group A streptococci secrete a variety of molecules, many of which are recognized as virulence factors important in the establishment of streptococcal infections. Among these extracellular products is streptococcal pyrogenic exotoxin A (SPE A, scarlet fever toxin A, erythrogenic toxin A) (1).
M, Roggiani, P M, Schlievert
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Hyperhidrosis Treated by Botulinum A Exotoxin

Dermatologic Surgery, 1998
Hyperhidrosis, or excessive sweating, can be emotionally challenging and socially and professionally disruptive, and there have been few effective treatments. Recently, botulinum toxin has been demonstrated to be an effective treatment for hyperhidrosis of the axillae and palms and for gustatory sweating.This article reviews the current treatments and ...
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Trafficking ofPseudomonas exotoxin a in mammalian cells

European Journal of Clinical Microbiology, 1985
Experiments designed to elucidate cellular internalization of Pseudomonas aeruginosa exotoxin A are described. Inhibition of protein synthesis was used as an index of the biological activity of exotoxin A, and a biotinyl-toxin: avidin-gold system to follow its movement on the ultrastructural level.
C B, Saelinger, R E, Morris, G, Foertsch
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Mice immunized with DNA encoding a modified Pseudomonas aeruginosa exotoxin A develop protective immunity against exotoxin intoxication

Vaccine, 2000
A recombinant plasmid, which contains the Pseudomonas aeruginosa exotoxin A (PE) gene with a C-terminal deletion, was inserted into expression vector pSecTag Xpress. The expression of this bacterial exotoxin in an animal cell was first demonstrated in 3T3 cell by transient transfection and western blot assay.
J W, Shiau, T K, Tang, Y L, Shih, C, Tai, Y Y, Sung, J L, Huang, H L, Yang   +6 more
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Pseudomonas aeruginosa exotoxin A

1997
Abstract Pseudomonas aeruginosa exotoxin A (PEA, MW 66 kDa, 613 amino acids, sequence accession number: PSEETA K01397) consists of three major domains (Allured et al. 1986), as indicated in Fig. 1. The N-terminal domain la (amino acids 1-252) binds to the ai-macroglobulin receptor at the cell surface (Kounnas et al.
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Modifications of Eyebrow Position With Botulinum Exotoxin A

Archives of Facial Plastic Surgery, 2002
To determine if clinically used botulinum exotoxin A (Botox) injections to the forehead and glabellar and crow's-feet regions result in modifications of eyebrow position.Prospective study.Academic medical center in St Louis, Mo.Twenty-nine adult patients treated with botulinum exotoxin A injections for rhytids.The eyebrow position at 13 different sites
Mimi S, Kokoska, Jason B, Amato, Christopher S, Hollenbeak, Dee Anna, Glaser   +3 more
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Immunotoxins containing Pseudomonas exotoxin A: a short history

Cancer Immunology, Immunotherapy, 2003
A large variety of monoclonal antibodies (MAb) have been identified that bind to antigens on cancer cells and there are many mechanisms by which antibodies can kill cancer cells. However, very few antibodies are able to kill sufficient numbers of cells to cause tumor regression in experimental animals and even fewer are useful in the treatment of ...
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