Results 1 to 10 of about 19,399 (188)

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface [PDF]

Nature Communications, 2018
The cellular toxicity of Pseudomonas exotoxin-S and -T depends on their activation by 14-3-3 but the underlying molecular mechanism is not fully understood.
Tobias Karlberg, Peter Hornyak, Ana Filipa Pinto, Stefina Milanova, Mahsa Ebrahimi, Mikael Lindberg, Nikolai Püllen, Axel Nordström, Elinor Löverli, Rémi Caraballo, Emily V. Wong, Katja Näreoja, Ann-Gerd Thorsell, Mikael Elofsson, Enrique M. De La Cruz, Camilla Björkegren, Herwig Schüler   +16 more
doaj   +8 more sources

T-cell receptor Vβ8 for detection of biologically active streptococcal pyrogenic exotoxin type C

Journal of Dairy Science, 2023
: Streptococcus pyogenes is an important human pathogen, commonly spread by airborne droplets but also by ingestion of contaminated food. Apart from causing infection, this pathogen produces 13 distinct types of streptococcal pyrogenic exotoxins (SPE ...
Reuven Rasooly, Paula Do, Bradley Hernlem   +2 more
doaj   +3 more sources

Pseudomonas aeruginosa exotoxin T induces potent cytotoxicity against a variety of murine and human cancer cell lines. [PDF]

J Med Microbiol, 2015
In patients with malignancy, the major barrier to achieving complete response is emergence of resistance to current chemotherapeutic agents. One of the major mechanisms by which tumour cells become resistant to therapies is by altering cellular drug targets through mutations and/or deletions.
Goldufsky J, Wood S, Hajihossainlou B, Rehman T, Majdobeh O, Kaufman HL, Ruby CE, Shafikhani SH.   +7 more
europepmc   +5 more sources

The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection.

PLoS ONE, 2012
The type III secretion system (T3SS) is a complex nanomachine of many pathogenic gram-negative bacteria. It forms a proteinaceous channel that is inserted into the host eukaryotic cell membrane for injection of bacterial proteins that manipulate host ...
Marlies Galle, Shouguang Jin, Pieter Bogaert, Mira Haegman, Peter Vandenabeele, Rudi Beyaert   +5 more
doaj   +5 more sources

Acquisition of toxin-encoding lysogenic bacteriophage elements enhances the virulence of pandemic Streptococcus pyogenes M1UK [PDF]

Infection and Immunity
Multiple countries have observed an alarming increase in scarlet fever cases, and invasive infections often associated with a new sublineage of Streptococcus pyogenes known as M1UK.
Juan Manuel Díaz, Jasmine E. J. Wells, Amanda C. Marple, Blake A. Shannon, Aanchal Rishi, Irene Martin, Allison McGeer, Matthew A. Croxen, Gregory J. Tyrrell, Mark J. Walker, Stephan Brouwer, John K. McCormick   +11 more
doaj   +2 more sources

Characterization of Multidrug-Resistant Trueperella (Arcanobacterium) pyogenes Isolates from Vertebral Osteomyelitis in Slaughtered Pigs [PDF]

Animals
Slaughterhouses serve as critical surveillance hubs for identifying subclinical and economically important diseases in food-producing animals. Trueperella (Arcanobacterium) pyogenes, an opportunistic pathogen commonly found on the mucous membranes of ...
In-Haeng Lee, Gun Lee, Hyeon Jeong Moon, Dae-Young Kim, Jong-Woog Choi, Yeong-Bin Baek, Sang-Ik Park, Dae-Sung Yoo, Jun Bong Lee, Bock-Gie Jung, Kwang-Jun Lee, Jun-Gyu Park   +11 more
doaj   +2 more sources

Prevalence of exoT Gene in Pseudomonas aeruginosa Isolated from Various Clinical Samples: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Pseudomonas aeruginosa (P. aeruginosa) is one of the most frequently co-infecting bacteria reported. Development of drug resistance, biofilm formation, cell associated factors make the P. aeruginosa more virulent.
Jagannath Dnyanoba Andhale, M Anjaneya Swamy, RN Misra   +2 more
doaj   +1 more source

Immunological Properties of Exotoxin A Toxoid - Detoxified Lipopolysaccharide - Gold Nanoparticles Conjugate Against Pseudomonas aeruginosa Infection [PDF]

Iranian Journal of Immunology, 2021
Background: Pseudomonas aeruginosa is an important opportunistic pathogen, especially in patients with compromised host defense. Objective: To prepare the conjugate of detoxified lipopolysaccharide (D-LPS) and exotoxin A toxoid (T-ETA) from P ...
Faezeh Najafzadeh, Asghar Tanomand, Azam Hadadi, Jafar Majidi   +3 more
doaj   +1 more source

Cell and receptor requirements for streptococcal pyrogenic exotoxin T-cell mitogenicity [PDF]

Infection and Immunity, 1991
Streptococcal pyrogenic exotoxins (SPEs) A, B, and C, like other members of the pyrogenic toxin family, are able to cause toxic shock-like syndromes. One of the major properties of these toxins is the ability to induce T-cell proliferation. Characterization of T cell mitogenicity associated with SPEs A, B, and C was undertaken.
B A, Leonard, P K, Lee, M K, Jenkins, P M, Schlievert   +3 more
openaire   +2 more sources

The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T–mediated virulence [PDF]

Journal of Clinical Investigation, 2007
Pseudomonas aeruginosa, an important cause of opportunistic infections in humans, delivers bacterial cytotoxins by type III secretion directly into the host cell cytoplasm, resulting in disruption of host cell signaling and host innate immunity. However, little is known about the fate of the toxins themselves following injection into the host cytosol ...
Priya, Balachandran, Leonard, Dragone, Lynne, Garrity-Ryan, Armando, Lemus, Arthur, Weiss, Joanne, Engel   +5 more
openaire   +2 more sources