Results 41 to 50 of about 19,438 (226)

Zinc Binding and Dimerization of Streptococcus pyogenes Pyrogenic Exotoxin C Are Not Essential for T-cell Stimulation [PDF]

Journal of Biological Chemistry, 2003
Streptococcal pyrogenic enterotoxin C (Spe-C) is a superantigen virulence factor produced by Streptococcus pyogenes that activates T-cells polyclonally. The biologically active form of Spe-C is thought to be a homodimer containing an essential zinc coordination site on each subunit, consisting of the residues His(167), His(201), and Asp(203 ...
Wieslaw, Swietnicki, Anne M, Barnie, Beverly K, Dyas, Robert G, Ulrich   +3 more
openaire   +2 more sources

Safety and Immunogenicity of a 4-Component Toxoid-Based Staphylococcus aureus Vaccine in Rhesus Macaques

Frontiers in Immunology, 2021
Staphylococcus aureus is a leading cause of significant morbidity and mortality and an enormous economic burden to public health worldwide. Infections caused by methicillin-resistant S.
Arundhathi Venkatasubramaniam, Grant Liao, Eunice Cho, Rajan P. Adhikari, Tom Kort, Frederick W. Holtsberg, Karen E. Elsass, Dean J. Kobs, Thomas L. Rudge, Keith D. Kauffman, Nickiana E. Lora, Daniel L. Barber, M. Javad Aman, Hatice Karauzum   +13 more
doaj   +1 more source

Staphylococcal exotoxins deliver activation signals to human T-cell clones via major histocompatibility complex class II molecules. [PDF]

Proceedings of the National Academy of Sciences, 1991
We investigated whether staphylococcal exotoxins (SEs), in addition to their capacity to induce T-cell activation restricted by the T-cell receptor (TCR) beta-chain variable region, can deliver an activation signal to human T-cell clones through major histocompatibility complex (MHC) class II molecules.
Spertini, F., Spits, H., Geha, R. S.
openaire   +3 more sources

Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen. [PDF]

, 2017
The inducible innate immune response to infection requires a concerted process of gene expression that is regulated at multiple levels. Most global analyses of the innate immune response have focused on transcription induced by defined immunostimulatory ...
Barry, Kevin C, Ingolia, Nicholas T, Vance, Russell E   +2 more
core   +3 more sources

Chemical Synthesis of Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii Capsular Polysaccharide Fragments as Leads for Cross‐Protection

Angewandte Chemie, Volume 138, Issue 6, 2 February 2026.
A total of 16 chemically synthesized capsular polysaccharide (CPS) fragments related to Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii were analyzed by glycan microarray. Comparative screening revealed three conserved epitopes that act as cross‐protective vaccine lead candidates against multidrug‐resistant (MDR) bacterial ...
Amar Kumar Mishra, Emelie E. Reuber, Diksha Rai, Leif E. Sander, Julia Duerr, Simon Y. Graeber, Marcus A. Mall, Bettina C. Fries, Peter H. Seeberger, Suvarn S. Kulkarni   +9 more
wiley   +2 more sources

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based onPseudomonasexotoxin A [PDF]

Proceedings of the National Academy of Sciences, 2012
Recombinant immunotoxins (RITs) are chimeric proteins that are being developed for cancer treatment. We have produced RITs that contain PE38, a portion of the bacterial proteinPseudomonasexotoxin A. Because the toxin is bacterial, it often induces neutralizing antibodies, which limit the number of treatment cycles and the effectiveness of the therapy ...
Ronit, Mazor, Aaron N, Vassall, Jaime A, Eberle, Richard, Beers, John E, Weldon, David J, Venzon, Kwong Y, Tsang, Itai, Benhar, Ira, Pastan   +8 more
openaire   +2 more sources

A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity [PDF]

, 2016
Many bacterial and viral pathogens (or their toxins), including Pseudomonas aeruginosa exotoxin A, require processing by host pro-protein convertases such as furin to cause disease.
Ferguson, Timothy E. G., Hamilton, Robert A., Martin, S. Lorraine, Reihill, James A., Walker, Brian   +4 more
core   +6 more sources

Determining the immunological characteristics of a novel human monoclonal antibody developed against staphylococcal enterotoxin B

Human Vaccines & Immunotherapeutics, 2020
Staphylococci are the main cause of nosocomial infections globally. The exotoxin staphylococcal enterotoxin B (SEB) produced by methicillin-resistant Staphylococcus aureus is a major cause of pathology after a staphylococcal infection.
Yuanyuan Liu, Zhen Song, Shuang Ge, Jinyong Zhang, Limin Xu, Feng Yang, Dongshui Lu, Ping Luo, Jiang Gu, Quanming Zou, Hao Zeng   +10 more
doaj   +1 more source

The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

Frontiers in Immunology, 2022
Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic.
Belinda S. Hall, Louise Tzung-Harn Hsieh, Sandra Sacre, Rachel E. Simmonds   +3 more
doaj   +1 more source

In-Vivo Expression Profiling of Pseudomonas aeruginosa Infections Reveals Niche-Specific and Strain-Independent Transcriptional Programs [PDF]

, 2011
Pseudomonas aeruginosa is a threatening, opportunistic pathogen causing disease in immunocompromised individuals. The hallmark of P. aeruginosa virulence is its multi-factorial and combinatorial nature.
Bielecki, Piotr, Puchałka, Jacek, Wos-Oxley, Melissa L, Loessner, Holger, Glik, Justyna, Kawecki, Marek, Nowak, Mariusz, Tümmler, Burkhard, Weiss, Siegfried, dos Santos, Vítor A P Martins   +9 more
core   +1 more source