Results 91 to 100 of about 81,192 (267)

P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

Journal of Neuroinflammation, 2008
Background The purinergic receptor P2x7 is expressed on myeloid cells as well as on CNS glial cells, and P2x7 activation has been shown to increase both glial and T-cell activation. These properties suggest a role in the development of autoimmune disease
Lin Shao X, Simonini Vittoria, Polak Paul E, Sharp Anthony J, Richardson Jill C, Bongarzone Ernesto R, Feinstein Douglas L   +6 more
doaj   +1 more source

CD73 Expression by CD4+ T Cells Marks Early Effector Memory T Cells

Immunology, EarlyView.
The role of CD73 in the development of naïve CD4+ T cells. Naïve CD4+ T cells, which are negative for CD25, CD44, and positive for CD62L, are depicted based on the expression of CD73. CD73− and CD73+ subpopulations among naïve CD4+ T cells bear distinct characteristics.
Luxia Chen, Sabine Ring, Anna Jurga, Florian C. Kurschus, Alexander Enk, Karsten Mahnke   +5 more
wiley   +1 more source

Gliotoxin Aggravates Experimental Autoimmune Encephalomyelitis by Triggering Neuroinflammation

Toxins, 2019
Gliotoxin (GTX) is the major and the most potent mycotoxin that is secreted by Aspergillus fumigatus, which is capable of injuring and killing microglial cells, astrocytes, and oligodendrocytes.
Thais Fernanda de Campos Fraga-Silva, Luiza Ayumi Nishiyama Mimura, Laysla de Campos Toledo Leite, Patrícia Aparecida Borim, Larissa Lumi Watanabe Ishikawa, James Venturini, Maria Sueli Parreira de Arruda, Alexandrina Sartori   +7 more
doaj   +1 more source

Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]

, 2008
B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Anderton, Stephen M., Bettelli, Estelle, Buch, Thorsten, Frommer, Friederike, Heinen, Tobias J. A. J., Mueller, Werner, Roers, Axel, Waisman, Ari, Wunderlich, F. Thomas, Yogev, Nir   +9 more
core   +1 more source

Oral Treatment With Heat Shock Protein 65‐Producing Lactococcus lactis Induces Regulatory T Cells, Modulating Inflammatory Response in Leishmania braziliensis Infection

Immunology, EarlyView.
Oral treatment with HSP65‐producing Lactococcus lactis after Leishmania braziliensis infection modulates inflammation by promoting lesion resolution through increased IL‐10 production and expansion of regulatory T cells. These findings highlight the potential of oral tolerance induction as a promising therapeutic strategy for chronic inflammatory ...
Camila Mattos Andrade, Ítalo da Silva Gonçalves, Maria Luiza das Neves Nascimento, Washington Luís Conrado Santos, Vasco Ariston Azevedo, Deborah Bittencourt Mothé, Juliana Perrone Menezes Fullam, Patrícia Sampaio Tavares Veras, Natalia Machado Tavares, Tatiani Uceli Maioli, Ana Maria Caetano Faria, Cláudia Ida Brodskyn   +11 more
wiley   +1 more source

SIRT1-based therapy targets a gene program involved in mitochondrial turnover in a model of retinal neurodegeneration

Scientific Reports
Neurodegenerative diseases of the eye such as optic neuritis (ON) are hallmarked by retinal ganglion cell (RGC) loss and optic nerve degeneration leading to irreversible blindness.
Brahim Chaqour, Jacob B. Rossman, Miranda Meng, Kimberly E. Dine, Ahmara G. Ross, Kenneth S. Shindler   +5 more
doaj   +1 more source

Hsp70 regulates immune response in experimental autoimmune encephalomyelitis.

PLoS ONE, 2014
Heat shock protein (Hsp)70 is one of the most important stress-inducible proteins. Intracellular Hsp70 not only mediates chaperone-cytoprotective functions but can also block multiple steps in the apoptosis pathway.
M José Mansilla, Carme Costa, Herena Eixarch, Vanja Tepavcevic, Mireia Castillo, Roland Martin, Catherine Lubetzki, Marie-Stéphane Aigrot, Xavier Montalban, Carmen Espejo   +9 more
doaj   +1 more source

The Role of MicroRNAs in Repair Processes in Multiple Sclerosis

Cells, 2020
Multiple sclerosis (MS) is an autoimmune disorder characterised by demyelination of central nervous system neurons with subsequent damage, cell death and disability.
Conor P. Duffy, Claire E. McCoy
doaj   +1 more source

Sympathetic innervation of human cervical lymph nodes: A potential neuroimmunomodulatory target for the treatment of T‐cell‐driven autoimmune diseases like MS?

Journal of Anatomy, EarlyView.
Recent animal studies have shown that the sympathetic nervous system (SNS) prevents disease activity of EAE (Experimental autoimmune encephalomyelitis, animal model of Multiple Sclerosis [MS]), presumably through adrenergic activity in the deep cervical lymph nodes (DCLNs).
Christopher Kremer, Claire Mackaaij, Suzanne A. M. W. Verlinde‐Schellekens, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +4 more
wiley   +1 more source

Kirenol attenuates experimental autoimmune encephalomyelitis by inhibiting differentiation of Th1 and th17 cells and inducing apoptosis of effector T cells. [PDF]

, 2015
Experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS), is characterized by CNS demyelination mediated by autoreactive T cells.
Deng, Wenbin, Fan, Xiaohang, Liu, Wenwei, Xiao, Juan, Yang, Lin, Yang, Rongbing   +5 more
core   +2 more sources