Results 101 to 110 of about 81,192 (267)

Phenolic compounds in species of the Blechnaceae

Plant Biology, EarlyView.
The occurrence of caffeic acid derivatives in 32 species of Blechnaceae revealed differences in the presence of rosmarinic acid and blechnic acid B, a novel compound in ferns. Abstract Rosmarinic acid and other caffeic and 4‐coumaric acid derivatives are widespread in land plants.
M. Ufland, M. Petersen
wiley   +1 more source

Targeting microglia-Th17 feed-forward loop to suppress autoimmune neuroinflammation

Journal of Neuroinflammation
Microglia and Th17 cells are the major immunopathogenic cells in multiple sclerosis and its animal model of immune aspects, experimental autoimmune encephalomyelitis (EAE).
Jun Xiao, Zihan Meng, Yao Lu, Zongchang Nie, Yujie Liu, Zhi Yao, Yingchi Zhang, Long Li   +7 more
doaj   +1 more source

Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis

Neural Regeneration Research, 2018
The transcription factor nuclear factor κB (NF-κB) plays major roles in inflammatory diseases through regulation of inflammation and cell viability. Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the ...
Yuan Yue, Sarrabeth Stone, Wensheng Lin
doaj   +1 more source

Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis [PDF]

, 2018
Demyelination and axonal injury are the key pathological processes in multiple sclerosis (MS), driven by inflammation and oxidative stress. Acrolein, a byproduct and instigator of oxidative stress, has been demonstrated as a neurotoxin in experimental ...
Acosta, Glen, Hayward, Lee, Mattson, David, Race, Nicholas, Shi, Riyi, Tang, Jonathan, Tian, Ran, Tully, Melissa, Zheng, Lingxing   +8 more
core   +1 more source

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener, Millie J. Thackray, I. Lorena Arancibia‐Cárcamo   +2 more
wiley   +1 more source

Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis. [PDF]

, 2019
BACKGROUND: Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE).
Chai, Zhi, Ciric, Bogoljub, Curtis, Mark T., Guo, Min-Fang, Li, Rui-Lan, Li, Yan-Hua, Ma, Cun-Gen, Rostami, A. M., Song, Guo-Bin, Sun, Man-Luan, Thome, Rodolfo, Xu, Fang, Zhang, Guang-Xian   +12 more
core   +1 more source

Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12

Glia, Volume 73, Issue 12, Page 2464-2482, December 2025.
Main Points Transcriptionally, P2RY12‐deficient microglia show heightened metabolic activity, iron handling and oxidative stress at baseline. Upon LPS challenge, impaired glutathione antioxidant responses suggest increased vulnerability to ferroptosis. ABSTRACT Microglia are the resident immune cells of the CNS.
Aida Oryza Lopez‐Ortiz, Madison Doceti, JaQuinta Thomas, Abigayle Duffy, Morgan Coburn, Akhabue K. Okojie, Audrey Lee, Elizabeth Aidita Sou, Alban Gaultier, Ukpong B. Eyo   +9 more
wiley   +1 more source

Activin A–Activated ALK4 Induces Pathogenic Th17‐Involved Endothelial–Mesenchymal Transition in Systemic Lupus Erythematosus–Associated Pulmonary Arterial Hypertension

Arthritis &Rheumatology, Volume 77, Issue 11, Page 1533-1547, November 2025.
Objective Autoimmune diseases, such as systemic lupus erythematosus (SLE), are associated with pulmonary arterial hypertension (PAH), a condition that can lead to heart failure. However, whether T cells also contribute to the occurrence of PAH in SLE has not been clarified.
Shuliang Jing, Junyan Qian, Hongjie Ying, Pei Mao, Mingxin Yao, Zhihong Wu, Harm J. Bogaard, Lie Wang, Mengtao Li, Jun Yang   +9 more
wiley   +1 more source

Hydroxycitric acid ameliorates inflammation and oxidative stress in mouse models of multiple sclerosis

Neural Regeneration Research, 2016
Hydroxycitric acid (HCA) is derived primarily from the Garcinia plant and is widely used for its anti-inflammatory effects. Multiple sclerosis can cause an inflammatory demyelination and axonal damage.
Mahdi Goudarzvand, Sanaz Afraei, Somaye Yaslianifard, Saleh Ghiasy, Ghazal Sadri, Mustafa Kalvandi, Tina Alinia, Ali Mohebbi, Reza Yazdani, Shahin Khadem Azarian, Abbas Mirshafiey, Gholamreza Azizi   +11 more
doaj   +1 more source

Elevated Prolactin Levels Are Associated With Increased Severity and Psychiatric Symptoms in Anti‐N‐Methyl‐D‐Aspartate Receptor Encephalitis

Brain and Behavior, Volume 15, Issue 11, November 2025.
Association of serum PRL with anti‐NMDAR encephalitis. ABSTRACT Background Autoimmune encephalitis, predominantly anti‐N‐methyl‐D‐aspartate receptor (anti‐NMDAR) encephalitis, is a central nervous system (CNS) autoimmune disorder. Prolactin (PRL), a pro‐inflammatory hormone implicated in autoimmune pathogenesis, may play a role in anti‐NMDAR ...
Xiaoyu Ma, Yaxin Lu, Yingying Xu, Shougang Guo, Weiqi Wang, Wei Shang, Wei Qiu, Pin Wang, Yaqing Shu, Yuge Wang   +9 more
wiley   +1 more source