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Microbiome Methods in Experimental Autoimmune Encephalomyelitis
Current Protocols, 2021AbstractMicrobiome composition studies are increasingly shedding light on animal models of disease. This paper describes a protocol for analyzing the gut microbiome composition prior to and after the induction of mice to experimental autoimmune encephalomyelitis (EAE), the principal animal model of the human neuroinflammatory demyelinating disease ...
David P, Daberkow +5 more
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Experimental Autoimmune Encephalomyelitis
2004Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system that is induced in laboratory animals by the generation of an immune response against myelin epitopes. It has been used as a prototype of Th1- and/or Th17-driven, organ-specific autoimmunity and as a model for the human disease ...
Praveen, Rao, Benjamin M, Segal
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Experimental Autoimmune Encephalomyelitis
2021Experimental autoimmune encephalomyelitis, originally experimental allergic encephalomyelitis, is the well-known animal model of multiple sclerosis, an immune- mediated, demyelinating, inflammatory chronic disease of the central nervous system. The experimental disease is widely utilized to test new therapies in preclinical studies, to investigate new ...
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Experimental Autoimmune Encephalomyelitis in the Mouse
Current Protocols, 2021AbstractThis article details the materials and methods required for both active induction and adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse strain using intact proteins or peptides from the two major myelin proteins: proteolipid protein (PLP) and myelin basic protein (MBP).
Collin, Laaker +4 more
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Acamprosate modulates experimental autoimmune encephalomyelitis
Inflammopharmacology, 2011This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS).The amino acid taurine has multiple biological activities including immunomodulation and neuromodulation.
Z, Sternberg +9 more
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Experimental Autoimmune Encephalomyelitis
2003Much of our present understanding of the pathogenesis in multiple sclerosis (MS) and other disorders of the central nervous system (CNS) is based on information gained through studying experimental animal models. Whereas the investigation of human tissue samples—obtained by biopsies or postmortem—can provide only a focused view at one given time-point ...
Hans-Peter Hartung, Bernd C. Kieseier
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Genetics of Experimental Autoimmune Encephalomyelitis
1999The genetic basis for susceptibility to experimental autoimmune encepha- lomyelitis (EAE) has been the subject of intense study for several decades. In spite of this long history, however, the eVort has only yielded small hints and contradictory leads to which genes influence susceptibility to this autoimmune disease.
J A, Encinas, V K, Kuchroo
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Experimental Autoimmune Encephalomyelitis in Primates
2008Due to their genetic and immunological proximity to humans, the common marmoset, Callithrix jacchus, provides an important bridge between rodent-based research and the human disease. Experimental autoimmune encephalomyelitis (EAE) induced in the outbred common marmoset provides a highly reproducible model of multiple sclerosis (MS) phenotypically ...
Smith, Paul A. +2 more
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Experimental Autoimmune Encephalomyelitis in Marmosets
2014Experimental autoimmune encephalomyelitis (EAE) in the common marmoset, a small-bodied Neotropical primate, is a well-known and validated animal model for multiple sclerosis (MS). This model can be used for exploratory research, i.e., investigating the pathogenic mechanisms involved in MS, and applied research, testing the efficacy of new potential ...
S Anwar, Jagessar +4 more
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Experimental Autoimmune Encephalomyelitis in the Rat
Current Protocols in Immunology, 2009AbstractThere are several diverse rat models of experimental autoimmune encephalomyelitis (EAE) that can be used to investigate the pathogenesis and regulation of autoimmunity against CNS myelin. The disease course of these models ranges from an acute monophasic disease with limited demyelination to a chronic relapsing or chronic progressive course ...
Mark, Mannie +2 more
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