The role of lipoprotein-associated phospholipase A2 in a murine model of experimental autoimmune uveoretinitis. [PDF]
PLoS ONE, 2015 Macrophage activation is, in part, regulated via hydrolysis of oxidised low density lipoproteins by Lipoprotein-Associated phospholipase A2 (Lp-PLA2), resulting in increased macrophage migration, pro-inflammatory cytokine release and chemokine expression.
G L Crawford +7 more
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Treatment of experimental autoimmune uveoretinitis with different natural compounds. [PDF]
Mol Med Rep, 2016 Uveitis is an important eye disease that potentially causes loss of sight. Although extensive studies have been conducted on uveitis, the exact pathogenesis remains to be determined. The effects of treatment with natural compounds on an experimental autoimmune uveoretinitis (EAU) rat model were examined in the present study.
Li M +6 more
europepmc +4 more sources
Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+CD25+ Foxp3 regulatory T cells [PDF]
International Journal of Ophthalmology, 2015 AIM:To determine the effects of rapamycin on experimental autoimmune uveoretinitis (EAU) and investigate of role of rapamycin on T cell subsets in the disease.
Li-Fei Yuan +5 more
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AAV2-mediated subretinal gene transfer of hIFN-α attenuates experimental autoimmune uveoretinitis in mice. [PDF]
PLoS ONE, 2011 BackgroundRecent reports show that gene therapy may provide a long-term, safe and effective intervention for human diseases. In this study, we investigated the effectiveness of adeno-associated virus 2 (AAV2) based human interferon-alpha (hIFN-α) gene ...
Lichun Tian +8 more
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Kinetic changes in microglia-related retinal transcripts in experimental autoimmune uveoretinitis (EAU) of B10.RIII mice [PDF]
Journal of NeuroinflammationIn this study the retinal transcriptome was investigated during the development of experimental autoimmune uveoretinitis (EAU) in mice. EAU was induced by immunizing B10.RIII mice with human interphotoreceptor retinoid binding protein (hIRBP) 161–180 ...
Maren Kasper +9 more
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Enhanced M2 Polarization of Retinal Microglia in Streptozotocin-Induced Diabetic Mice upon Autoimmune Stimulation [PDF]
BiomedicinesBackground: This study aimed to investigate the impact of the diabetic environment on the development of experimental autoimmune uveoretinitis (EAU) and the activation status of microglia in the eye.
Yoshiaki Nishio +5 more
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Regulatory effects of IFN-β on the development of experimental autoimmune uveoretinitis in B10RIII mice. [PDF]
PLoS ONE, 2011 BACKGROUND: Experimental autoimmune uveoretinitis (EAU) serves as a model for human intraocular inflammation. IFN-β has been used in the treatment of certain autoimmune diseases.
Min Sun +5 more
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A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocyanine green dye [PDF]
Disease Models & Mechanisms, 2015 We have developed a method to label and image myeloid cells infiltrating the mouse retina and choroid in vivo, using a single depot injection of indocyanine green dye (ICG).
Dawn A. Sim +12 more
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AAV2-mediated combined subretinal delivery of IFN-α and IL-4 reduces the severity of experimental autoimmune uveoretinitis. [PDF]
PLoS ONE, 2012 We previously showed that adeno-associated virus 2 (AAV2) mediated subretinal delivery of human interferon-alpha (IFN-α) could effectively inhibit experimental autoimmune uveoretinitis (EAU).
Lichun Tian +5 more
doaj +2 more sources
Photoreceptor mitochondrial oxidative stress in early experimental autoimmune uveoretinitis. [PDF]
Br J Ophthalmol, 2007 In early S-antigen induced experimental uveitis (EAU), photoreceptor mitochondrial proteins are nitrated prior to macrophage infiltration of the retina, suggesting that oxidative stress is an initial event in the development of EAU. We attempted to detect the oxidative stress and localise it in the EAU retina.Lewis rats were immunised with S-antigen in
Rajendram R, Saraswathy S, Rao NA.
europepmc +4 more sources