Results 31 to 40 of about 2,734 (194)

Targeted delivery of autoantigen to dendritic cells prevents development of spontaneous uveitis

Frontiers in Immunology, 2023
Restoration of immunological tolerance to self antigens has been a major drive in understanding the mechanisms of, and developing new treatments for, autoimmune and autoinflammatory disease.
Izabela P. Klaska, Tian Yu, Tian Yu, Rosie Fordyce, Koju Kamoi, Koju Kamoi, Richard J. Cornall, Cristina Martin-Granados, Lucia Kuffova, Lucia Kuffova, John V. Forrester   +10 more
doaj   +1 more source

Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis

Clinical &Translational Immunology, Volume 12, Issue 12, 2023., 2023
Non‐infectious uveitis has a range of ocular and systemic autoimmune and autoinflammatory causes. When the retina is involved, blood‐retinal barrier breakdown can lead to vision loss. Specific cytokines stand out as promoting intraocular inflammation. This article reviews the involvement of inflammatory cytokines – including tumour necrosis factor (TNF)
Lisia Barros Ferreira, Keryn A Williams, Giles Best, Cameron D Haydinger, Justine R Smith   +4 more
wiley   +1 more source

Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells

Frontiers in Immunology, 2020
Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen.
Fauziyya Muhammad, Priscilla N. Avalos, M. H. Mursalin, Jian-Xing Ma, Michelle C. Callegan, Michelle C. Callegan, Michelle C. Callegan, Darren J. Lee, Darren J. Lee, Darren J. Lee   +9 more
doaj   +1 more source

Chemical Biology of αGalCer: A Chemist's Toolbox for the Stimulation of Invariant Natural Killer T (iNKT) Cells

European Journal of Organic Chemistry, Volume 2022, Issue 26, July 14, 2022., 2022
A guide to the chemist's toolbox for the stimulation of invariant natural killer (iNKT) cells. This Review encompasses the synthetic strategies for the preparation of the iNKT cell agonist α‐galactosylceramide (αGalCer), its TH1/TH2 skewing analogs, and other synthetic probes for the elucidation of mechanisms of αGalCer trafficking.
Cecilia Romanò, Mads H. Clausen
wiley   +1 more source

Advances in exosome therapies in ophthalmology–From bench to clinical trial

Acta Ophthalmologica, Volume 100, Issue 3, Page 243-252, May 2022., 2022
Abstract During the last decade, the fields of advanced and personalized therapeutics have been constantly evolving, utilizing novel techniques such as gene editing and RNA therapeutic approaches. However, the method of delivery and tissue specificity remain the main hurdles of these approaches.
Amisha Sanghani, Petru Andriesei, Konstantinos N. Kafetzis, Aristides D. Tagalakis, Cynthia Yu‐Wai‐Man   +4 more
wiley   +1 more source

Quantifying the Role of Stochasticity in the Development of Autoimmune Disease

Cells, 2020
In this paper, we propose and analyse a mathematical model for the onset and development of autoimmune disease, with particular attention to stochastic effects in the dynamics.
Lindsay B. Nicholson, Konstantin B. Blyuss, Farzad Fatehi   +2 more
doaj   +1 more source

Immunopathophysiology and clinical impact of uveitis in inflammatory rheumatic diseases: An update

European Journal of Clinical Investigation, Volume 51, Issue 8, August 2021., 2021
Abstract Background Uveitis is one of the most frequent ophthalmologic manifestations in rheumatology. Uveal inflammation can underlie a systemic inflammatory rheumatic disease (SIRD) in approximately 30% of cases with a significant burden on the quality of life since it represents a cause of blindness in up to 20% of cases in Western countries ...
Elvis Hysa, Carlo Alberto Cutolo, Emanuele Gotelli, Greta Pacini, Carlotta Schenone, Elke O Kreps, Vanessa Smith, Maurizio Cutolo   +7 more
wiley   +1 more source

Inflammatory Responses Potentiate GAS M Protein Induced Cardiac Damage in an Experimental Model of Rheumatic Heart Disease. [PDF]

Immun Inflamm Dis
Group A streptococcal M protein elicit antibody and T‐cell responses that cross react with cardiac and connective tissue proteins in the Rat Autoimmune Valvulitis (RAV) model of rheumatic heart disease. Bordetella pertussis Toxin induce a robust Th1 response that potentiates the autoimmune process in the RAV model A robust Th1/Th17 response was found ...
Rafeek RAM, Reynolds SL, Pandey M, McMillan DJ, Sriprakash KS, Good MF, Ketheesan N.   +6 more
europepmc   +2 more sources

Role of Janus Kinase (JAK) Inhibitor in Autoimmune Ocular Inflammation: A Systematic Review

Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021
Purpose. To evaluate the effectiveness of Janus kinase (JAK) inhibitors for the treatment of patients with autoimmune disease and associated inflammatory ocular diseases. Methods. We identified relevant literature by screening the MEDLINE, PubMed, and Cochrane databases for randomized controlled trials, cohort studies, case controls, and case reports ...
Ji Wen, Huifang Hu, Menglin Chen, Hang Yang, Yi Zhao, Yi Liu, Chiara Posarelli   +6 more
wiley   +1 more source

A Role for Folate in Microbiome‐Linked Control of Autoimmunity

Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021
The microbiome exerts considerable control over immune homeostasis and influences susceptibility to autoimmune and autoinflammatory disease (AD/AID) such as inflammatory bowel disease (IBD), multiple sclerosis (MS), type 1 diabetes (T1D), psoriasis, and uveitis.
Christine Mölzer, Heather M. Wilson, Lucia Kuffova, John V. Forrester, Mingyi Zhao   +4 more
wiley   +1 more source