Results 61 to 70 of about 2,734 (194)

Lipoprotein‐associated phospholipase A2: The story continues

Medicinal Research Reviews, Volume 40, Issue 1, Page 79-134, January 2020., 2020
Abstract Inflammation is thought to play an important role in the pathogenesis of vascular diseases. Lipoprotein‐associated phospholipase A2 (Lp‐PLA2) mediates vascular inflammation through the regulation of lipid metabolism in blood, thus, it has been extensively investigated to identify its role in vascular inflammation‐related diseases, mainly ...
Fubao Huang, Kai Wang, Jianhua Shen
wiley   +1 more source

Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models [PDF]

, 2016
Myeloid cells make a pivotal contribution to tissue homeostasis during inflammation. Both tissue-specific resident populations and infiltrating myeloid cells can cause tissue injury through aberrant activation and/or dysregulated activity.
Ali, RR, Bainbridge, JW, Cristante, E, Gardner, PJ, Liyanage, SE, Luhmann, UFO, Ribeiro, J, Sampson, RD   +7 more
core   +1 more source

Suppressive effects of a novel compound on interphotoreceptor retinoid-binding protein-induced experimental autoimmune uveoretinitis in rats

Allergology International, 1999
The immunosuppressive effect of ethyl O-(N-(pcarboxyphenyl)-carbamoyl)-mycophenolate(CAM) was examined in interphotoreceptor retinoid-binding protein (IRBP)-induced experimental autoimmune uveoretinitis (EAU) in rats.
Jun-ichi Sakai, Takeshi Kezuka, Hidetoshi Yokoi, Annabelle A Okada, Masahiko Usui, Junichiro Mizuguchi, Yutaro Kaneko   +6 more
doaj   +1 more source

Small heat shock protein αA-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis. [PDF]

PLoS ONE, 2012
The small heat shock protein, αA-crystallin null (αA-/-) mice are known to be more prone to retinal degeneration than the wild type mice in Experimental Autoimmune Uveoretinitis (EAU).
Narsing A Rao, Sindhu Saraswathy, Geeta Pararajasegaram, Suraj P Bhat   +3 more
doaj   +1 more source

Environmental conditioning in the control of macrophage thrombospondin-1 production [PDF]

, 2012
Thrombospondin-1 (TSP-1) is a multifunctional protein which is secreted into the extracellular matrix during inflammation, where it modulates numerous components of the immune infiltrate.
Copland, David A., Dick, Andrew D., Fordham, Jezrom B., Hua, Jing, Morwood, Sarah R., Nicholson, Lindsay B., Schewitz-Bowers, Lauren P.   +6 more
core   +1 more source

Stochastic effects in autoimmune dynamics [PDF]

, 2018
Among various possible causes of autoimmune disease, an important role is played by infections that can result in a breakdown of immune tolerance, primarily through the mechanism of ``molecular mimicry".
Alexander, Allen, Allen, Allen, Alonso, Altan-Bonnet, Antia, Bartels, Ben Ezra, Bitmansour, Black, Black, Black, Blattman, Blyuss, Blyuss, Boldison, Borghans, Borghans, Brauer, Braumann, Bruna, Burroughs, Burroughs, Burroughs, Carneiro, Chao, Conway, Davies, Deenick, Detours, Earnest, Ercolini, Fujinami, Gardiner, Gillespie, Gillespie, Grossman, Grossman, Grossman, Hammarling, Hayot, Hufton, Iwami, Iwami, Kerr, Kuske, León, León, León, Mandal, McKane, Neofytou, Nicholson, Noest, Nylander, Pahle, Perelson, Prat, Reynolds, Root-Bernstein, Römer, Santamaria, Scherer, Segel, Skapenko, Stefanova, Stirk, Stirk, van den Berg, van Kampen, von Herrath, Wallace, Wolf, Wu, Yuan, Øksendal   +76 more
core   +3 more sources

ISEV2023 Abstract Book

, 2023
Journal of Extracellular Vesicles, Volume 12, Issue S1, May 2023.
wiley   +1 more source

A low concentration of Tacrolimus/semifluorinated alkane (SFA) eyedrop suppresses intraocular inflammation in experimental models of uveitis [PDF]

, 2017
PURPOSE: Corticosteroids remain the mainstay therapy for uveitis, a major cause of blindness in the working age population. However, a substantial number of patients cannot benefit from the therapy due to steroids resistance or intolerance.
De Majumdar, S, Korward, J, Pettigrew, Andrew, Scherer, D, Subinya, M, Xu, H   +5 more
core   +3 more sources

Toxicidade intravítrea da rapamicina em olhos de coelhos [PDF]

, 2009
PURPOSE: To evaluate retinal toxicity of varying doses of rapamycin when injected intravitreally in rabbits. Rapamycin is a potent immunosuppressive agent with significant antitumor and antiangiogenic properties, clinically approved for prevention of ...
CHEVEZ-BARRIOS, Patricia, KHAN, Palwasha, KIVILCIM, Muhamet, MANZANO, Roberta Pereira de Almeida, PEYMAN, Gholam A., TAKAHASHI, Walter   +5 more
core   +2 more sources

Retinal S-antigen Th1 cell epitope mapping in patients with Behcet's disease [PDF]

Background - Retinal S-antigen (S-Ag) is a most characterized autoantigen of autoimmune uveitis. The recognized immunodominant epitope of human S-Ag in patients with uveitis has not been identified. In this study, we selected certain patients with active
Du, L.P., He, H., Kijlstra, A., Lin, X.M., Yang, P.Z., Zhao, C.L., Zhou, H.Y.   +6 more
core   +2 more sources