Results 71 to 80 of about 2,734 (194)

Sialoadhesin Promotes the Inflammatory Response in Experimental Autoimmune Uveoretinitis [PDF]

The Journal of Immunology, 2006
Abstract Macrophages are a prominent component of the effector cell compartment in a number of CD4+ T cell-mediated organ-specific autoimmune diseases. In this study, we investigated the role of the sialic acid binding Ig-like lectin sialoadhesin (Sn, Siglec-1) in a model of interphotoreceptor retinal binding protein peptide-induced ...
Hui-Rong, Jiang, Lenias, Hwenda, Kimmo, Makinen, Cornelia, Oetke, Paul R, Crocker, John V, Forrester   +5 more
openaire   +2 more sources

CD44 Participates to Extramedullary Haematopoiesis Onset by Mediating the Interplay Between Monocytes and Haematopoietic Stem Cells in Myelofibrosis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 14, July 2025.
ABSTRACT Extramedullary haematopoiesis (EMH) refers to blood generation outside of the bone marrow (BM). In Myelofibrosis (MF), a myeloproliferative neoplasm, the disruption of BM microenvironment promotes haematopoietic stem and progenitor cells (HSPCs) mobilisation, resulting in the onset of EMH in the spleen, and then in splenomegaly.
Margherita Mirabile, Camilla Tombari, Anita Neroni, Lara Tavernari, Ruggiero Norfo, Elisa Bianchi, Monica Maccaferri, Barbara Mora, Sandra Parenti, Chiara Carretta, Matteo Bertesi, Marica Malerba, Elisa Papa, Luca Fabbiani, Niccolò Bartalucci, Paola Guglielmelli, Leonardo Potenza, Lorena Losi, Francesco Passamonti, Enrico Tagliafico, Mario Luppi, Sebastiano Rontauroli, Alessandro Maria Vannucchi, Rossella Manfredini, on behalf of the MYNERVA (Myeloid NEoplasms Research Venture AIRC) investigators   +24 more
wiley   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, Volume 12, Issue 24, June 26, 2025.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Involvement of Angiopoietin 2 and vascular endothelial growth factor in uveitis.

PLoS ONE, 2023
PurposeAngiopoietin (Ang) 2 is released from vascular endothelial cells by the stimulation of vascular endothelial growth factor (VEGF)A. Ang2 increases the expression of leukocyte adhesion molecules on endothelial cells via nuclear factor κB. The aim of
Kayo Suzuki, Daiju Iwata, Kenichi Namba, Keitaro Hase, Miki Hiraoka, Miyuki Murata, Nobuyoshi Kitaichi, Richard Foxton, Susumu Ishida   +8 more
doaj   +1 more source

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Periodontology 2000, Volume 94, Issue 1, Page 257-414, February 2024.
Abstract Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases ...
Richard J. Miron, Nathan E. Estrin, Anton Sculean, Yufeng Zhang   +3 more
wiley   +1 more source

Notch Signaling and T-Helper Cells in EAE/MS [PDF]

, 2013
The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in ...
Bassil, Ribal, Elyaman, Wassim, Orent, William   +2 more
core   +3 more sources

Development of Clarstatin, a Novel Drug Lead for the Therapy of Autoimmune Uveitis

Pharmaceutics
We describe the design, synthesis, and activity of a potent thiourea-bridged backbone cyclic peptidomimetic known as Clarstatin, comprising a 5-amino acid sequence (Q/D)1-(R/K)2-X3-X4-A5-(Gln/Asp)1-(Arg/Lys)2-AA3-AA4-Ala5-based on a motif called “shared ...
Shira Merzbach, Amnon Hoffman, Philip Lazarovici, Chaim Gilon, Radgonde Amer   +4 more
doaj   +1 more source

Choroidal mast cells in retinal pathology: a potential target for intervention. [PDF]

, 2015
Mast cells are important in the initiation of ocular inflammation, but the consequences of mast cell degranulation on ocular pathology remain uncharacterized.
Behar-Cohen, F., Bergin, C., Besson-Lescure, B., Bousquet, E., Castaneda, B., de Kozak, Y., Lorena, V., Naud, M.C., Thillaye-Goldenberg, B., Zhao, M.   +9 more
core   +1 more source

IL-10 has a protective role in experimental autoimmune uveoretinitis [PDF]

International Immunology, 1998
The role of IL-10 in the regulation of ocular autoimmune disease was studied in experimental autoimmune uveoretinitis (EAU) elicited in mice by immunization with the retinal antigen interphotoreceptor retinoid binding protein. IL-10-deficient mice were susceptible to EAU, indicating that pathogenesis can occur without presence of IL-10.
L V, Rizzo, H, Xu, C C, Chan, B, Wiggert, R R, Caspi   +4 more
openaire   +2 more sources

Use of optical coherence tomography and electroretinography to evaluate retinal pathology in a mouse model of autoimmune uveitis.

PLoS ONE, 2013
Experimental autoimmune uveoretinitis (EAU) in mice is a model for human autoimmune uveitis. Longitudinal follow-up is only possible by non-invasive techniques, but the information obtained by visual fundus examination can be limited.
Jun Chen, Haohua Qian, Reiko Horai, Chi-Chao Chan, Rachel R Caspi   +4 more
doaj   +1 more source